50 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA4	GATA binding protein 4. (442 aa)
	ENSCHIP00000000870	Ig-like domain-containing protein. (132 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (219 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	SLIT3	Slit guidance ligand 3. (1320 aa)
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	ENG	Endoglin. (649 aa)
	RBM15	RNA binding motif protein 15. (962 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	PARVA	Parvin alpha. (412 aa)
	TBX5	T-box transcription factor 5. (594 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	MKS1	MKS transition zone complex subunit 1. (645 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	PROX1	Prospero homeobox 1. (734 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (988 aa)
	TBX20	T-box transcription factor 20. (449 aa)
	DNAH11	Dynein axonemal heavy chain 11. (4508 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2993 aa)
	TBX3	T-box transcription factor 3. (749 aa)
	SMAD6	Mothers against decapentaplegic homolog. (497 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	TBX2	T-box transcription factor 2. (771 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1022 aa)
	EGLN1	Uncharacterized protein. (422 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (765 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	GATA6	GATA binding protein 6. (592 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	SMAD7	Mothers against decapentaplegic homolog. (427 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	BMPR1A	ENSCHIP00000023678	ENSCHIP00000000640	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP4	BMPR2	ENSCHIP00000023678	ENSCHIP00000022191	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	ENG	ENSCHIP00000023678	ENSCHIP00000033223	Bone morphogenetic protein 4.	Endoglin.	0.417
BMP4	FGF8	ENSCHIP00000023678	ENSCHIP00000016903	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.763
BMP4	GATA4	ENSCHIP00000023678	ENSCHIP00000005452	Bone morphogenetic protein 4.	GATA binding protein 4.	0.609
BMP4	GATA6	ENSCHIP00000023678	ENSCHIP00000020060	Bone morphogenetic protein 4.	GATA binding protein 6.	0.773
BMP4	HEY2	ENSCHIP00000023678	ENSCHIP00000033371	Bone morphogenetic protein 4.	Hes related family bHLH transcription factor with YRPW motif 2.	0.506
BMP4	ISL1	ENSCHIP00000023678	ENSCHIP00000025978	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.733
BMP4	JAG1	ENSCHIP00000023678	ENSCHIP00000023437	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.763
BMP4	NKX2-5	ENSCHIP00000023678	ENSCHIP00000017688	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.693
BMP4	NOG	ENSCHIP00000023678	ENSCHIP00000005264	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.999
BMP4	NOTCH1	ENSCHIP00000023678	ENSCHIP00000023681	Bone morphogenetic protein 4.	Notch receptor 1.	0.562
BMP4	SMAD4	ENSCHIP00000023678	ENSCHIP00000020573	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.949
BMP4	SMAD6	ENSCHIP00000023678	ENSCHIP00000009966	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.860
BMP4	SMAD7	ENSCHIP00000023678	ENSCHIP00000021001	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.837
BMP4	SMO	ENSCHIP00000023678	ENSCHIP00000027079	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.639
BMP4	TBX2	ENSCHIP00000023678	ENSCHIP00000012825	Bone morphogenetic protein 4.	T-box transcription factor 2.	0.542
BMP4	TBX20	ENSCHIP00000023678	ENSCHIP00000007813	Bone morphogenetic protein 4.	T-box transcription factor 20.	0.445
BMP4	TBX3	ENSCHIP00000023678	ENSCHIP00000009495	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.711