(35 nodes) Lung epithelium development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIMP2	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)
	GRHL2	Grainyhead like transcription factor 2. (622 aa)
	YAP1	Yes associated protein 1. (503 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (330 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	FOXA1	Forkhead box A1. (468 aa)
	THRB	Thyroid hormone receptor beta. (476 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	STRA6	Stimulated by retinoic acid 6. (654 aa)
	GATA6	GATA binding protein 6. (592 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4303 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (460 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (219 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	AGR2	Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
	THRA	Thyroid hormone receptor alpha. (511 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	RCN3	Reticulocalbin 3. (336 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	ADAMTSL2	ADAMTS like 2. (957 aa)
	KLF2	Kruppel like factor 2. (361 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2115 aa)
	HOXA5	Homeobox A5. (270 aa)
	PPP3R1	Uncharacterized protein. (170 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	RBBP9	RB binding protein 9, serine hydrolase. (186 aa)
	NKX2-1	NK2 homeobox 1. (370 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA1	ENSCHIP00000008838	ENSCHIP00000027706	Anterior gradient 2, protein disulphide isomerase family member.	Forkhead box A1.	0.554
AGR2	SPDEF	ENSCHIP00000008838	ENSCHIP00000017084	Anterior gradient 2, protein disulphide isomerase family member.	SAM pointed domain containing ETS transcription factor.	0.784
ASCL1	BMP4	ENSCHIP00000010956	ENSCHIP00000023678	Achaete-scute family bHLH transcription factor 1.	Bone morphogenetic protein 4.	0.446
ASCL1	CREB1	ENSCHIP00000010956	ENSCHIP00000033719	Achaete-scute family bHLH transcription factor 1.	cAMP responsive element binding protein 1.	0.585
ASCL1	CTNNB1	ENSCHIP00000010956	ENSCHIP00000031016	Achaete-scute family bHLH transcription factor 1.	Catenin beta 1.	0.403
ASCL1	NFIB	ENSCHIP00000010956	ENSCHIP00000009358	Achaete-scute family bHLH transcription factor 1.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.502
ASCL1	NKX2-1	ENSCHIP00000010956	ENSCHIP00000028337	Achaete-scute family bHLH transcription factor 1.	NK2 homeobox 1.	0.617
ASCL1	SHH	ENSCHIP00000010956	ENSCHIP00000027767	Achaete-scute family bHLH transcription factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.683
ASCL1	SOX9	ENSCHIP00000010956	ENSCHIP00000024523	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 9.	0.709
ASCL1	YAP1	ENSCHIP00000010956	ENSCHIP00000017099	Achaete-scute family bHLH transcription factor 1.	Yes associated protein 1.	0.406
BMP4	ASCL1	ENSCHIP00000023678	ENSCHIP00000010956	Bone morphogenetic protein 4.	Achaete-scute family bHLH transcription factor 1.	0.446
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	FGF10	ENSCHIP00000023678	ENSCHIP00000010028	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.887
BMP4	FOXA1	ENSCHIP00000023678	ENSCHIP00000027706	Bone morphogenetic protein 4.	Forkhead box A1.	0.426
BMP4	GATA6	ENSCHIP00000023678	ENSCHIP00000020060	Bone morphogenetic protein 4.	GATA binding protein 6.	0.773
BMP4	KLF2	ENSCHIP00000023678	ENSCHIP00000004621	Bone morphogenetic protein 4.	Kruppel like factor 2.	0.423
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SOX9	ENSCHIP00000023678	ENSCHIP00000024523	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.769
BMP4	WNT2	ENSCHIP00000023678	ENSCHIP00000007601	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.465
CREB1	ASCL1	ENSCHIP00000033719	ENSCHIP00000010956	cAMP responsive element binding protein 1.	Achaete-scute family bHLH transcription factor 1.	0.585