(40 nodes) Mammary gland morphogenesis network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRG3	Uncharacterized protein. (382 aa)
	ENSCHIP00000000397	Uncharacterized protein. (328 aa)
	BSX	Brain specific homeobox. (232 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	PML	Promyelocytic leukemia. (868 aa)
	ELF3	E74 like ETS transcription factor 3. (372 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TBX3	T-box transcription factor 3. (749 aa)
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	CCL11	C-C motif chemokine. (97 aa)
	PTCH1	Patched 1. (1453 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	TBX2	T-box transcription factor 2. (771 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (722 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	EPHA2	EPH receptor A2. (975 aa)
	AREG	Amphiregulin. (264 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	PHB2	Prohibitin. (289 aa)
	CSMD2	CUB and Sushi multiple domains 2. (3313 aa)
	CSMD1	CUB and Sushi multiple domains 1. (3068 aa)
	SCRIB	Scribble planar cell polarity protein. (1582 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	KDM5B	Lysine demethylase 5B. (1539 aa)
	LRRC1	Leucine rich repeat containing 1. (517 aa)
	NTN1	Netrin 1. (496 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	AR	Androgen receptor. (891 aa)
	DDR1	Tyrosine-protein kinase receptor. (915 aa)
	CAPN1	Uncharacterized protein; Belongs to the peptidase C2 family. (744 aa)
	VDR	Vitamin D receptor. (491 aa)
	RXFP1	Relaxin family peptide receptor 1. (763 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
	STAT6	Signal transducer and activator of transcription. (841 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CAV1	ENSCHIP00000024342	ENSCHIP00000020742	Androgen receptor.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.402
AR	ESR1	ENSCHIP00000024342	ENSCHIP00000012243	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.767
AR	MED1	ENSCHIP00000024342	ENSCHIP00000028752	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.649
AR	SRC	ENSCHIP00000024342	ENSCHIP00000002619	Androgen receptor.	Tyrosine-protein kinase.	0.731
AR	STAT6	ENSCHIP00000024342	ENSCHIP00000031225	Androgen receptor.	Signal transducer and activator of transcription.	0.505
AREG	CAV1	ENSCHIP00000015057	ENSCHIP00000020742	Amphiregulin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.493
AREG	CCL11	ENSCHIP00000015057	ENSCHIP00000010436	Amphiregulin.	C-C motif chemokine.	0.486
AREG	ESR1	ENSCHIP00000015057	ENSCHIP00000012243	Amphiregulin.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.590
AREG	SRC	ENSCHIP00000015057	ENSCHIP00000002619	Amphiregulin.	Tyrosine-protein kinase.	0.729
BMP4	FGF10	ENSCHIP00000023678	ENSCHIP00000010028	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.887
BMP4	GLI3	ENSCHIP00000023678	ENSCHIP00000014153	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.499
BMP4	LRP5	ENSCHIP00000023678	ENSCHIP00000021146	Bone morphogenetic protein 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.503
BMP4	PTCH1	ENSCHIP00000023678	ENSCHIP00000011891	Bone morphogenetic protein 4.	Patched 1.	0.737
BMP4	TBX2	ENSCHIP00000023678	ENSCHIP00000012825	Bone morphogenetic protein 4.	T-box transcription factor 2.	0.542
BMP4	TBX3	ENSCHIP00000023678	ENSCHIP00000009495	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.711
BMP4	TGFB1	ENSCHIP00000023678	ENSCHIP00000008885	Bone morphogenetic protein 4.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.495
BMP4	TGFBR2	ENSCHIP00000023678	ENSCHIP00000008226	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.657
BMP4	WNT5A	ENSCHIP00000023678	ENSCHIP00000015533	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.731
BTRC	GLI3	ENSCHIP00000016844	ENSCHIP00000014153	Beta-transducin repeat containing E3 ubiquitin protein ligase.	GLI family zinc finger 3.	0.953
BTRC	NFKB1	ENSCHIP00000016844	ENSCHIP00000004382	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Nuclear factor kappa B subunit 1.	0.786