(27 nodes) Mammary gland duct morphogenesis network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	EPHA2	EPH receptor A2. (975 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (722 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	PTCH1	Patched 1. (1453 aa)
	CCL11	C-C motif chemokine. (97 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	TBX3	T-box transcription factor 3. (749 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	PML	Promyelocytic leukemia. (868 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
	VDR	Vitamin D receptor. (491 aa)
	DDR1	Tyrosine-protein kinase receptor. (915 aa)
	AR	Androgen receptor. (891 aa)
	NTN1	Netrin 1. (496 aa)
	LRRC1	Leucine rich repeat containing 1. (517 aa)
	KDM5B	Lysine demethylase 5B. (1539 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	SCRIB	Scribble planar cell polarity protein. (1582 aa)
	CSMD1	CUB and Sushi multiple domains 1. (3068 aa)
	CSMD2	CUB and Sushi multiple domains 2. (3313 aa)
	PHB2	Prohibitin. (289 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	AREG	Amphiregulin. (264 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSCHIP00000024342	ENSCHIP00000012243	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.767
AR	MED1	ENSCHIP00000024342	ENSCHIP00000028752	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.649
AR	SRC	ENSCHIP00000024342	ENSCHIP00000002619	Androgen receptor.	Tyrosine-protein kinase.	0.731
AREG	CCL11	ENSCHIP00000015057	ENSCHIP00000010436	Amphiregulin.	C-C motif chemokine.	0.486
AREG	ESR1	ENSCHIP00000015057	ENSCHIP00000012243	Amphiregulin.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.590
AREG	SRC	ENSCHIP00000015057	ENSCHIP00000002619	Amphiregulin.	Tyrosine-protein kinase.	0.729
CCL11	AREG	ENSCHIP00000010436	ENSCHIP00000015057	C-C motif chemokine.	Amphiregulin.	0.486
CCL11	CSF1	ENSCHIP00000010436	ENSCHIP00000033660	C-C motif chemokine.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.724
CSF1	CCL11	ENSCHIP00000033660	ENSCHIP00000010436	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	C-C motif chemokine.	0.724
CSF1	EPHA2	ENSCHIP00000033660	ENSCHIP00000014598	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	EPH receptor A2.	0.713
CSF1	SRC	ENSCHIP00000033660	ENSCHIP00000002619	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tyrosine-protein kinase.	0.718
CSF1	TGFB1	ENSCHIP00000033660	ENSCHIP00000008885	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.636
EPHA2	CSF1	ENSCHIP00000014598	ENSCHIP00000033660	EPH receptor A2.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.713
EPHA2	FGF10	ENSCHIP00000014598	ENSCHIP00000010028	EPH receptor A2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.695
ESR1	AR	ENSCHIP00000012243	ENSCHIP00000024342	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Androgen receptor.	0.767
ESR1	AREG	ENSCHIP00000012243	ENSCHIP00000015057	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Amphiregulin.	0.590
ESR1	MED1	ENSCHIP00000012243	ENSCHIP00000028752	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.986
ESR1	PHB2	ENSCHIP00000012243	ENSCHIP00000017241	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Prohibitin.	0.817
ESR1	SRC	ENSCHIP00000012243	ENSCHIP00000002619	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.994
ESR1	TGFB1	ENSCHIP00000012243	ENSCHIP00000008885	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.648