STRINGSTRING
CCN1 CCN1 MAPK1 MAPK1 FZD5 FZD5 WNT2 WNT2 PLG PLG SOCS3 SOCS3 VASH2 VASH2 NSDHL NSDHL VASH1 VASH1 HS6ST1 HS6ST1 PKD1 PKD1 HES1 HES1 GGNBP2 GGNBP2 FBXW8 FBXW8 PKD2 PKD2 MAP2K1 MAP2K1 NOTCH2 NOTCH2 FOSL1 FOSL1 NR2F2 NR2F2 AKT1 AKT1 APELA APELA PLCD3 PLCD3 SPINT1 SPINT1 RBM15 RBM15 HEY2 HEY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCN1Cellular communication network factor 1. (382 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
VASH2Vasohibin 2. (355 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (380 aa)
VASH1Vasohibin 1. (363 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (416 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GGNBP2Gametogenetin binding protein 2. (738 aa)
FBXW8F-box and WD repeat domain containing 8. (599 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
NOTCH2Notch receptor 2. (2471 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (419 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
APELAUncharacterized protein. (54 aa)
PLCD3Phosphoinositide phospholipase C. (782 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (508 aa)
RBM15RNA binding motif protein 15. (962 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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