41 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGT	Angiotensinogen; Belongs to the serpin family. (476 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	LHX1	LIM homeobox 1. (406 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	GDNF	Glial cell derived neurotrophic factor. (211 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	SIX1	SIX homeobox 1. (284 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SIRT6	Sirtuin 6. (335 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	GREM1	Gremlin. (184 aa)
	SIX2	SIX homeobox 2. (296 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	HOXD13	Homeobox D13. (340 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	RTN4	Reticulon. (1194 aa)
	FKBPL	FKBP prolyl isomerase like. (345 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SIX4	SIX homeobox 4. (784 aa)
	BTBD7	BTB domain containing 7. (1123 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (315 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	SFRP1	Secreted frizzled related protein 1. (308 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	MAP3K13	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1001 aa)
	SHOX2	Short stature homeobox 2. (319 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	SOX8	SRY-box transcription factor 8. (534 aa)
	PHB2	Prohibitin. (289 aa)
	HOXB7	Homeobox B7. (217 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	AR	Androgen receptor. (891 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CTNNB1	ENSCHIP00000024651	ENSCHIP00000031016	Tyrosine-protein kinase.	Catenin beta 1.	0.622
AGT	TGFB1	ENSCHIP00000007185	ENSCHIP00000008885	Angiotensinogen; Belongs to the serpin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.543
AGT	TNF	ENSCHIP00000007185	ENSCHIP00000004561	Angiotensinogen; Belongs to the serpin family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.458
AR	CTNNB1	ENSCHIP00000024342	ENSCHIP00000031016	Androgen receptor.	Catenin beta 1.	0.943
AR	ESR1	ENSCHIP00000024342	ENSCHIP00000012243	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.767
AR	SOX9	ENSCHIP00000024342	ENSCHIP00000024523	Androgen receptor.	SRY-box transcription factor 9.	0.526
AR	TNF	ENSCHIP00000024342	ENSCHIP00000004561	Androgen receptor.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.426
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	FGF10	ENSCHIP00000023678	ENSCHIP00000010028	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.887
BMP4	FGF7	ENSCHIP00000023678	ENSCHIP00000014609	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.707
BMP4	GDNF	ENSCHIP00000023678	ENSCHIP00000027133	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.603
BMP4	GREM1	ENSCHIP00000023678	ENSCHIP00000006985	Bone morphogenetic protein 4.	Gremlin.	0.946
BMP4	HGF	ENSCHIP00000023678	ENSCHIP00000005606	Bone morphogenetic protein 4.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.574
BMP4	HOXB7	ENSCHIP00000023678	ENSCHIP00000017865	Bone morphogenetic protein 4.	Homeobox B7.	0.402
BMP4	LHX1	ENSCHIP00000023678	ENSCHIP00000025202	Bone morphogenetic protein 4.	LIM homeobox 1.	0.400
BMP4	NOG	ENSCHIP00000023678	ENSCHIP00000005264	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.999
BMP4	SFRP1	ENSCHIP00000023678	ENSCHIP00000012579	Bone morphogenetic protein 4.	Secreted frizzled related protein 1.	0.501
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SHOX2	ENSCHIP00000023678	ENSCHIP00000015506	Bone morphogenetic protein 4.	Short stature homeobox 2.	0.525