(34 nodes) Labyrinthine layer development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDX2	Caudal type homeobox 2. (306 aa)
	GGNBP2	Gametogenetin binding protein 2. (738 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	GCM1	Glial cells missing transcription factor 1. (427 aa)
	GRHL2	Grainyhead like transcription factor 2. (622 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	HS6ST1	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (416 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	EGLN1	Uncharacterized protein. (422 aa)
	VASH1	Vasohibin 1. (363 aa)
	CDX4	Caudal type homeobox 4. (283 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (380 aa)
	RSPO3	R-spondin 3. (303 aa)
	VASH2	Vasohibin 2. (355 aa)
	SOCS3	Suppressor of cytokine signaling 3. (229 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	GJB5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4878 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
	SPINT2	Serine peptidase inhibitor, Kunitz type 2. (250 aa)
	FBXW8	F-box and WD repeat domain containing 8. (599 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	PCDH12	Protocadherin 12. (1195 aa)
	PLCD3	Phosphoinositide phospholipase C. (782 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (508 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	ST14	Suppression of tumorigenicity 14. (890 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	CCN1	Cellular communication network factor 1. (382 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BIRC6	ENSCHIP00000027335	ENSCHIP00000004844	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Baculoviral IAP repeat containing 6.	0.473
AKT1	GRB2	ENSCHIP00000027335	ENSCHIP00000015407	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.530
AKT1	MAP2K1	ENSCHIP00000027335	ENSCHIP00000024037	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.457
AKT1	MAPK1	ENSCHIP00000027335	ENSCHIP00000000204	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.947
AKT1	ZFP36L1	ENSCHIP00000027335	ENSCHIP00000026339	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ZFP36 ring finger protein like 1.	0.433
BIRC6	AKT1	ENSCHIP00000004844	ENSCHIP00000027335	Baculoviral IAP repeat containing 6.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.473
BMP7	LEF1	ENSCHIP00000006043	ENSCHIP00000030629	Bone morphogenetic protein 7.	HMG box domain-containing protein.	0.521
CDX2	GCM1	ENSCHIP00000029734	ENSCHIP00000018527	Caudal type homeobox 2.	Glial cells missing transcription factor 1.	0.799
FZD5	LEF1	ENSCHIP00000003369	ENSCHIP00000030629	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	HMG box domain-containing protein.	0.542
FZD5	WNT2	ENSCHIP00000003369	ENSCHIP00000007601	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.917
GCM1	CDX2	ENSCHIP00000018527	ENSCHIP00000029734	Glial cells missing transcription factor 1.	Caudal type homeobox 2.	0.799
GCM1	PCDH12	ENSCHIP00000018527	ENSCHIP00000029605	Glial cells missing transcription factor 1.	Protocadherin 12.	0.749
GCM1	VASH2	ENSCHIP00000018527	ENSCHIP00000008795	Glial cells missing transcription factor 1.	Vasohibin 2.	0.618
GRB2	AKT1	ENSCHIP00000015407	ENSCHIP00000027335	Growth factor receptor bound protein 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.530
GRB2	MAP2K1	ENSCHIP00000015407	ENSCHIP00000024037	Growth factor receptor bound protein 2.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.527
GRB2	MAPK1	ENSCHIP00000015407	ENSCHIP00000000204	Growth factor receptor bound protein 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.720
LEF1	BMP7	ENSCHIP00000030629	ENSCHIP00000006043	HMG box domain-containing protein.	Bone morphogenetic protein 7.	0.521
LEF1	FZD5	ENSCHIP00000030629	ENSCHIP00000003369	HMG box domain-containing protein.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.542
LEF1	RSPO3	ENSCHIP00000030629	ENSCHIP00000011558	HMG box domain-containing protein.	R-spondin 3.	0.472
LEF1	WNT2	ENSCHIP00000030629	ENSCHIP00000007601	HMG box domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.682