(37 nodes) Coronary vasculature development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRDM1	PR/SET domain 1. (851 aa)
	ENSCHIP00000001052	Uncharacterized protein. (65 aa)
	ZBTB14	Zinc finger and BTB domain containing 14. (448 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1884 aa)
	ENSCHIP00000003122	SNX17_FERM_C domain-containing protein. (205 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (256 aa)
	PLXND1	Plexin D1. (1926 aa)
	ARID2	AT-rich interaction domain 2. (1835 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (433 aa)
	SRF	Serum response factor. (509 aa)
	SNX17	Sorting nexin 17. (470 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (834 aa)
	SMAD6	Mothers against decapentaplegic homolog. (497 aa)
	DCTN5	Uncharacterized protein. (182 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	MEGF8	Multiple EGF like domains 8. (2836 aa)
	APLN	Apelin. (72 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1261 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	GATA6	GATA binding protein 6. (592 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	SGCD	Sarcoglycan delta. (289 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	ENSCHIP00000024963	Uncharacterized protein. (163 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
	CPLANE1	Ciliogenesis and planar polarity effector 1. (3120 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
	APELA	Uncharacterized protein. (54 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS6	SNX17	ENSCHIP00000029016	ENSCHIP00000009469	ADAM metallopeptidase with thrombospondin type 1 motif 6.	Sorting nexin 17.	0.443
APELA	APLN	ENSCHIP00000029361	ENSCHIP00000015839	Uncharacterized protein.	Apelin.	0.431
APELA	APLNR	ENSCHIP00000029361	ENSCHIP00000028073	Uncharacterized protein.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.848
APLN	APELA	ENSCHIP00000015839	ENSCHIP00000029361	Apelin.	Uncharacterized protein.	0.431
APLN	APLNR	ENSCHIP00000015839	ENSCHIP00000028073	Apelin.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.998
APLNR	APELA	ENSCHIP00000028073	ENSCHIP00000029361	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.848
APLNR	APLN	ENSCHIP00000028073	ENSCHIP00000015839	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin.	0.998
ARID2	SETD2	ENSCHIP00000007348	ENSCHIP00000019636	AT-rich interaction domain 2.	SET domain containing 2, histone lysine methyltransferase.	0.421
BMP4	GATA6	ENSCHIP00000023678	ENSCHIP00000020060	Bone morphogenetic protein 4.	GATA binding protein 6.	0.773
BMP4	GPC3	ENSCHIP00000023678	ENSCHIP00000019503	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.415
BMP4	HAND2	ENSCHIP00000023678	ENSCHIP00000009629	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.682
BMP4	HEY2	ENSCHIP00000023678	ENSCHIP00000033371	Bone morphogenetic protein 4.	Hes related family bHLH transcription factor with YRPW motif 2.	0.506
BMP4	NOTCH1	ENSCHIP00000023678	ENSCHIP00000023681	Bone morphogenetic protein 4.	Notch receptor 1.	0.562
BMP4	PRDM1	ENSCHIP00000023678	ENSCHIP00000027475	Bone morphogenetic protein 4.	PR/SET domain 1.	0.488
BMP4	SMAD6	ENSCHIP00000023678	ENSCHIP00000009966	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.860
BMP4	TGFBR1	ENSCHIP00000023678	ENSCHIP00000025782	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.799
GATA6	BMP4	ENSCHIP00000020060	ENSCHIP00000023678	GATA binding protein 6.	Bone morphogenetic protein 4.	0.773
GATA6	HAND2	ENSCHIP00000020060	ENSCHIP00000009629	GATA binding protein 6.	Heart and neural crest derivatives expressed 2.	0.723
GATA6	SRF	ENSCHIP00000020060	ENSCHIP00000009082	GATA binding protein 6.	Serum response factor.	0.708
GPC3	BMP4	ENSCHIP00000019503	ENSCHIP00000023678	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Bone morphogenetic protein 4.	0.415