6 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	SOX9	ENSCHIP00000023678	ENSCHIP00000024523	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.769
BMP4	WNT2	ENSCHIP00000023678	ENSCHIP00000007601	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.465
BMP4	WNT2B	ENSCHIP00000023678	ENSCHIP00000004954	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.525
CTNNB1	BMP4	ENSCHIP00000031016	ENSCHIP00000023678	Catenin beta 1.	Bone morphogenetic protein 4.	0.800
CTNNB1	SOX9	ENSCHIP00000031016	ENSCHIP00000024523	Catenin beta 1.	SRY-box transcription factor 9.	0.937
CTNNB1	TNF	ENSCHIP00000031016	ENSCHIP00000004561	Catenin beta 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.730
CTNNB1	WNT2	ENSCHIP00000031016	ENSCHIP00000007601	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.852
CTNNB1	WNT2B	ENSCHIP00000031016	ENSCHIP00000004954	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.822
SOX9	BMP4	ENSCHIP00000024523	ENSCHIP00000023678	SRY-box transcription factor 9.	Bone morphogenetic protein 4.	0.769
SOX9	CTNNB1	ENSCHIP00000024523	ENSCHIP00000031016	SRY-box transcription factor 9.	Catenin beta 1.	0.937
SOX9	TNF	ENSCHIP00000024523	ENSCHIP00000004561	SRY-box transcription factor 9.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.473
SOX9	WNT2B	ENSCHIP00000024523	ENSCHIP00000004954	SRY-box transcription factor 9.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.415
TNF	CTNNB1	ENSCHIP00000004561	ENSCHIP00000031016	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	Catenin beta 1.	0.730
TNF	SOX9	ENSCHIP00000004561	ENSCHIP00000024523	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	SRY-box transcription factor 9.	0.473
WNT2	BMP4	ENSCHIP00000007601	ENSCHIP00000023678	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Bone morphogenetic protein 4.	0.465
WNT2	CTNNB1	ENSCHIP00000007601	ENSCHIP00000031016	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Catenin beta 1.	0.852
WNT2	WNT2B	ENSCHIP00000007601	ENSCHIP00000004954	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.526
WNT2B	BMP4	ENSCHIP00000004954	ENSCHIP00000023678	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Bone morphogenetic protein 4.	0.525
WNT2B	CTNNB1	ENSCHIP00000004954	ENSCHIP00000031016	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Catenin beta 1.	0.822