STRINGSTRING
SOX8 SOX8 DLG1 DLG1 NKX3-1 NKX3-1 ADAMTS16 ADAMTS16 TIMELESS TIMELESS FRS2 FRS2 LAMA5 LAMA5 MMP14 MMP14 TBX20 TBX20 SOCS3 SOCS3 GDF7 GDF7 CTSZ CTSZ TGFBR2 TGFBR2 CLIC4 CLIC4 EDN1 EDN1 TGFB1 TGFB1 SRF SRF PLXNA1 PLXNA1 TBX3 TBX3 BTBD7 BTBD7 FGF10 FGF10 PPP1CA PPP1CA BMP2 BMP2 CCL11 CCL11 DCHS1 DCHS1 WT1 WT1 TIE1 TIE1 RSPO3 RSPO3 PTCH1 PTCH1 GNA13 GNA13 ESR1 ESR1 SFRP1 SFRP1 TBX2 TBX2 GLI3 GLI3 DLL4 DLL4 EPHA2 EPHA2 FGF7 FGF7 TCF21 TCF21 DAG1 DAG1 AREG AREG FAT4 FAT4 HNF1B HNF1B GRB2 GRB2 WNT5A WNT5A BCL2 BCL2 PKD1 PKD1 RASIP1 RASIP1 IHH IHH RDH10 RDH10 BTRC BTRC FGF8 FGF8 GBX2 GBX2 YAP1 YAP1 SEMA3C SEMA3C PHB2 PHB2 ILK ILK GREB1 GREB1 GRHL2 GRHL2 CSMD2 CSMD2 GCM1 GCM1 CELSR1 CELSR1 GDF2 GDF2 FGF2 FGF2 GPC3 GPC3 FOXF1 FOXF1 WNT1 WNT1 CSMD1 CSMD1 NPNT NPNT SMAD4 SMAD4 CITED1 CITED1 LRP5 LRP5 SPINT2 SPINT2 EDNRA EDNRA PAX8 PAX8 SEMA3E SEMA3E SOX10 SOX10 KDM5B KDM5B PKD2 PKD2 HOXA11 HOXA11 BMP4 BMP4 NOTCH1 NOTCH1 AR AR PROX1 PROX1 DDR1 DDR1 SOX9 SOX9 PKHD1 PKHD1 EYA1 EYA1 LHX1 LHX1 SFRP2 SFRP2 GDNF GDNF FEM1B FEM1B WNT6 WNT6 FOXA1 FOXA1 SHH SHH VDR VDR MKS1 MKS1 TP63 TP63 NKX2-1 NKX2-1 CTNNBIP1 CTNNBIP1 NFATC4 NFATC4 MED1 MED1 HS3ST3B1 HS3ST3B1 ESRP2 ESRP2 DLG2 DLG2 SIX1 SIX1 MET MET LOC102177760 LOC102177760 SPINT1 SPINT1 TGM2 TGM2 LEF1 LEF1 CTNNB1 CTNNB1 CTSH CTSH GREB1L GREB1L SLIT2 SLIT2 KRAS KRAS ST14 ST14 HOXB13 HOXB13 RBM15 RBM15 FGF1 FGF1 ENG ENG PAX2 PAX2 WNT9B WNT9B CSF1 CSF1 DLG5 DLG5 TMEM59L TMEM59L PAK1 PAK1 STK4 STK4 PPP3R1 PPP3R1 HHIP HHIP HOXA5 HOXA5 SRC SRC KDR KDR FZD5 FZD5 HOXA13 HOXA13 SPRY2 SPRY2 GZF1 GZF1 PLXND1 PLXND1 PML PML EXT1 EXT1 NOG NOG ENSCHIP00000005724 ENSCHIP00000005724 HS3ST3A1 HS3ST3A1 BMP7 BMP7 HOXD13 HOXD13 NRARP NRARP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX8SRY-box transcription factor 8. (534 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
NKX3-1NK3 homeobox 1. (239 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1279 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
MMP14ZnMc domain-containing protein. (584 aa)
TBX20T-box transcription factor 20. (449 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
GDF7Growth differentiation factor 7. (451 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (304 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
EDN1Endothelin 1. (202 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SRFSerum response factor. (509 aa)
PLXNA1Plexin_cytopl domain-containing protein. (255 aa)
TBX3T-box transcription factor 3. (749 aa)
BTBD7BTB domain containing 7. (1123 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (385 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
CCL11C-C motif chemokine. (97 aa)
DCHS1Dachsous cadherin-related 1. (3258 aa)
WT1WT1 transcription factor. (450 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
RSPO3R-spondin 3. (303 aa)
PTCH1Patched 1. (1453 aa)
GNA13G protein subunit alpha 13. (377 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
TBX2T-box transcription factor 2. (771 aa)
GLI3GLI family zinc finger 3. (1614 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
EPHA2EPH receptor A2. (975 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TCF21Transcription factor 21. (179 aa)
DAG1Dystroglycan 1. (895 aa)
AREGAmphiregulin. (264 aa)
FAT4FAT atypical cadherin 4. (4982 aa)
HNF1BHNF1 homeobox B. (558 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
RASIP1Ras interacting protein 1. (961 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
YAP1Yes associated protein 1. (503 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
PHB2Prohibitin. (289 aa)
ILKIntegrin linked kinase. (452 aa)
GREB1Uncharacterized protein. (1944 aa)
GRHL2Grainyhead like transcription factor 2. (622 aa)
CSMD2CUB and Sushi multiple domains 2. (3313 aa)
GCM1Glial cells missing transcription factor 1. (427 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2710 aa)
GDF2Growth differentiation factor 2. (430 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
FOXF1Forkhead box F1. (391 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CSMD1CUB and Sushi multiple domains 1. (3068 aa)
NPNTNephronectin. (606 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (247 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (250 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PAX8Paired box 8. (457 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
SOX10SRY-box transcription factor 10. (469 aa)
KDM5BLysine demethylase 5B. (1539 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
HOXA11Homeobox A11. (317 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
ARAndrogen receptor. (891 aa)
PROX1Prospero homeobox 1. (734 aa)
DDR1Tyrosine-protein kinase receptor. (915 aa)
SOX9SRY-box transcription factor 9. (525 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4040 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
LHX1LIM homeobox 1. (406 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
FEM1BFem-1 homolog B. (627 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FOXA1Forkhead box A1. (468 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
VDRVitamin D receptor. (491 aa)
MKS1MKS transition zone complex subunit 1. (645 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
NKX2-1NK2 homeobox 1. (370 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (388 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
DLG2Discs large MAGUK scaffold protein 2. (901 aa)
SIX1SIX homeobox 1. (284 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
LOC102177760Plexin A1. (1661 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (508 aa)
TGM2Transglutaminase 2. (687 aa)
LEF1HMG box domain-containing protein. (430 aa)
CTNNB1Catenin beta 1. (781 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1911 aa)
SLIT2Slit guidance ligand 2. (1457 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ST14Suppression of tumorigenicity 14. (890 aa)
HOXB13Homeobox B13. (285 aa)
RBM15RNA binding motif protein 15. (962 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ENGEndoglin. (649 aa)
PAX2Paired box 2. (467 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
TMEM59LTransmembrane protein 59 like. (349 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
STK4Serine/threonine kinase 4. (487 aa)
PPP3R1Uncharacterized protein. (170 aa)
HHIPHedgehog interacting protein. (701 aa)
HOXA5Homeobox A5. (270 aa)
SRCTyrosine-protein kinase. (538 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
HOXA13Homeobox A13. (388 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
GZF1GDNF inducible zinc finger protein 1. (710 aa)
PLXND1Plexin D1. (1926 aa)
PMLPromyelocytic leukemia. (868 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSCHIP00000005724Uncharacterized protein. (62 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
HOXD13Homeobox D13. (340 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (18%) [HD]