STRINGSTRING
CHD7 CHD7 HEY2 HEY2 ENG ENG BMP10 BMP10 FHL2 FHL2 MED1 MED1 ADGRG6 ADGRG6 TGFBR1 TGFBR1 NOTCH1 NOTCH1 SOS1 SOS1 EGLN1 EGLN1 FOXH1 FOXH1 DLL4 DLL4 ENSCHIP00000013896 ENSCHIP00000013896 TEK TEK SRF SRF CAV3 CAV3 BMP7 BMP7 NOG NOG S1PR1 S1PR1 ADAMTS1 ADAMTS1 BMPR1A BMPR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENGEndoglin. (649 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
NOTCH1Notch receptor 1. (2508 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
EGLN1Uncharacterized protein. (422 aa)
FOXH1Forkhead box H1. (360 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
ENSCHIP00000013896Uncharacterized protein. (179 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
SRFSerum response factor. (509 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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