STRINGSTRING
LOC108635363 LOC108635363 SLC45A3 SLC45A3 IRS2 IRS2 MID1IP1 MID1IP1 ABCD2 ABCD2 P2RY6 P2RY6 GUCA2A GUCA2A EPM2AIP1 EPM2AIP1 LHCGR LHCGR GPLD1 GPLD1 PTH PTH SCAP SCAP TREM2 TREM2 APOA5 APOA5 TNF TNF MLYCD MLYCD PPP4R3B PPP4R3B BEND3 BEND3 SIRT1 SIRT1 INS INS GUCA1A GUCA1A LOC102190194 LOC102190194 SNCA SNCA APOA4 APOA4 ENSCHIP00000010160 ENSCHIP00000010160 ELOVL5 ELOVL5 NOS3 NOS3 NR1H3 NR1H3 PTPN2 PTPN2 ACTN3 ACTN3 GUCA1B GUCA1B PPARD PPARD CD74 CD74 INSR INSR ENSCHIP00000012671 ENSCHIP00000012671 DDB1 DDB1 AKT2 AKT2 GCK GCK PODN PODN PPARG PPARG PMAIP1 PMAIP1 ENO1 ENO1 PPARGC1A PPARGC1A APOC2 APOC2 AVPR1B AVPR1B IFNG IFNG ADORA2B ADORA2B HTR2A HTR2A NCS1 NCS1 NR1D1 NR1D1 ENSCHIP00000017929 ENSCHIP00000017929 ZBTB20 ZBTB20 FOXO1 FOXO1 PRKCE PRKCE VCP VCP LPGAT1 LPGAT1 IGF1 IGF1 SLC4A4 SLC4A4 GUCA2B GUCA2B ENSCHIP00000021464 ENSCHIP00000021464 ABCD1 ABCD1 GPD1 GPD1 PLIN5 PLIN5 MLXIPL MLXIPL ANXA1 ANXA1 NR1H4 NR1H4 ABCG4 ABCG4 KAT2A KAT2A LOC102186084 LOC102186084 GCG GCG CLYBL CLYBL APOE APOE PARK7 PARK7 ENSCHIP00000025560 ENSCHIP00000025560 GPER1 GPER1 P2RX7 P2RX7 KAT2B KAT2B ENSCHIP00000026945 ENSCHIP00000026945 AKT1 AKT1 PTGS2 PTGS2 PRXL2C PRXL2C WDR5 WDR5 DYRK2 DYRK2 IL1B IL1B PLA2G3 PLA2G3 PID1 PID1 SREBF1 SREBF1 PSEN1 PSEN1 NOS1 NOS1 ENSCHIP00000031771 ENSCHIP00000031771 PPARA PPARA STARD4 STARD4 APP APP BMP6 BMP6 ADIPOQ ADIPOQ FGF1 FGF1 NR1H2 NR1H2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108635363Ig-like domain-containing protein. (298 aa)
SLC45A3Solute carrier family 45 member 3. (550 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
MID1IP1MID1 interacting protein 1. (182 aa)
ABCD2ATP binding cassette subfamily D member 2. (741 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
GUCA2AGuanylate cyclase activator 2A. (109 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (848 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
SCAPSREBF chaperone. (1278 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
APOA5Apolipoprotein A5. (368 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
MLYCDMalonyl-CoA decarboxylase. (524 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (820 aa)
BEND3BEN domain containing 3. (829 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
GUCA1AUncharacterized protein. (205 aa)
LOC102190194Uncharacterized protein. (935 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
APOA4Apolipoprotein A4. (380 aa)
ENSCHIP00000010160Uncharacterized protein. (252 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
NR1H3Uncharacterized protein. (447 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (417 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
GUCA1BGuanylate cyclase activator 1B. (201 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
CD74CD74 molecule. (261 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
ENSCHIP00000012671BHLH domain-containing protein. (304 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
GCKPhosphotransferase. (465 aa)
PODNPodocan. (614 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
ENO1Enolase 1. (434 aa)
PPARGC1ARRM domain-containing protein. (797 aa)
APOC2Apolipoprotein C2. (103 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
NCS1Neuronal calcium sensor 1. (190 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (616 aa)
ENSCHIP00000017929Uncharacterized protein. (84 aa)
ZBTB20Zinc finger and BTB domain containing 20. (751 aa)
FOXO1Forkhead box O1. (668 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
SLC4A4Anion exchange protein. (1125 aa)
GUCA2BGuanylate cyclase activator 2B. (113 aa)
ENSCHIP00000021464Uncharacterized protein. (135 aa)
ABCD1ATP binding cassette subfamily D member 1. (737 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (358 aa)
PLIN5Perilipin; Belongs to the perilipin family. (456 aa)
MLXIPLMLX interacting protein like. (854 aa)
ANXA1Annexin. (346 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
ABCG4ATP binding cassette subfamily G member 4. (658 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
LOC102186084Uncharacterized protein. (293 aa)
GCGGlucagon. (180 aa)
CLYBLCitrate lyase beta like. (329 aa)
APOEApolipoprotein E. (326 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
ENSCHIP00000025560Ig-like domain-containing protein. (271 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (810 aa)
ENSCHIP00000026945Enolase_C domain-containing protein. (279 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PRXL2CPeroxiredoxin like 2C. (228 aa)
WDR5WD repeat domain 5. (334 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (599 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
PID1Phosphotyrosine interaction domain containing 1. (217 aa)
SREBF1Uncharacterized protein. (68 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
ENSCHIP00000031771C2 domain-containing protein. (204 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
STARD4StAR related lipid transfer domain containing 4. (224 aa)
APPAmyloid beta precursor protein. (770 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
ADIPOQC1q domain-containing protein. (283 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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