Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYLD | FADD | ENSCHIP00000032398 | ENSCHIP00000004023 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.887 |
| CYLD | MLKL | ENSCHIP00000032398 | ENSCHIP00000020882 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Mixed lineage kinase domain like pseudokinase. | 0.736 |
| CYLD | RIPK1 | ENSCHIP00000032398 | ENSCHIP00000032711 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Receptor interacting serine/threonine kinase 1. | 0.994 |
| CYLD | RIPK3 | ENSCHIP00000032398 | ENSCHIP00000016204 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.768 |
| CYLD | TLR3 | ENSCHIP00000032398 | ENSCHIP00000015102 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.408 |
| CYLD | TNF | ENSCHIP00000032398 | ENSCHIP00000004561 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.915 |
| DNM1L | PGAM5 | ENSCHIP00000028514 | ENSCHIP00000020194 | Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | PGAM family member 5, mitochondrial serine/threonine protein phosphatase. | 0.430 |
| FADD | CYLD | ENSCHIP00000004023 | ENSCHIP00000032398 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | 0.887 |
| FADD | FAS | ENSCHIP00000004023 | ENSCHIP00000010893 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Uncharacterized protein. | 0.991 |
| FADD | FASLG | ENSCHIP00000004023 | ENSCHIP00000026401 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | FasL; Belongs to the tumor necrosis factor family. | 0.988 |
| FADD | MLKL | ENSCHIP00000004023 | ENSCHIP00000020882 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Mixed lineage kinase domain like pseudokinase. | 0.927 |
| FADD | RIPK1 | ENSCHIP00000004023 | ENSCHIP00000032711 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Receptor interacting serine/threonine kinase 1. | 0.999 |
| FADD | RIPK3 | ENSCHIP00000004023 | ENSCHIP00000016204 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.999 |
| FADD | TLR3 | ENSCHIP00000004023 | ENSCHIP00000015102 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.641 |
| FADD | TNF | ENSCHIP00000004023 | ENSCHIP00000004561 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.911 |
| FADD | TP53 | ENSCHIP00000004023 | ENSCHIP00000030141 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.803 |
| FAS | FADD | ENSCHIP00000010893 | ENSCHIP00000004023 | Uncharacterized protein. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.991 |
| FAS | FASLG | ENSCHIP00000010893 | ENSCHIP00000026401 | Uncharacterized protein. | FasL; Belongs to the tumor necrosis factor family. | 0.992 |
| FAS | MLKL | ENSCHIP00000010893 | ENSCHIP00000020882 | Uncharacterized protein. | Mixed lineage kinase domain like pseudokinase. | 0.404 |
| FAS | RIPK1 | ENSCHIP00000010893 | ENSCHIP00000032711 | Uncharacterized protein. | Receptor interacting serine/threonine kinase 1. | 0.814 |
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