(39 nodes) ERK1 and ERK2 cascade network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
	AVP	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (167 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	EDN1	Endothelin 1. (202 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	C1QL4	Complement C1q like 4. (238 aa)
	KARS1	Lysine--tRNA ligase. (623 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (316 aa)
	ENSCHIP00000015409	Lysine--tRNA ligase. (599 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1077 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (774 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	ENSCHIP00000032619	ANK_REP_REGION domain-containing protein. (266 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1635 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (480 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (335 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (490 aa)
	NOD2	Uncharacterized protein. (982 aa)
	HESX1	HESX homeobox 1. (185 aa)
	LOC102175492	ANK_REP_REGION domain-containing protein. (1589 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	GRB10	Growth factor receptor bound protein 10. (591 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	TF	Transferrin; Belongs to the transferrin family. (698 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1235 aa)
	MT3	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (954 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK1	ENSCHIP00000024651	ENSCHIP00000000204	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.428
ABL1	MAPK3	ENSCHIP00000024651	ENSCHIP00000015503	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.401
ABL1	RAPGEF1	ENSCHIP00000024651	ENSCHIP00000017361	Tyrosine-protein kinase.	Rap guanine nucleotide exchange factor 1.	0.570
AVP	EDN1	ENSCHIP00000006784	ENSCHIP00000008821	Arginine vasopressin; Belongs to the vasopressin/oxytocin family.	Endothelin 1.	0.502
BRAF	FGF2	ENSCHIP00000019379	ENSCHIP00000019134	B-Raf proto-oncogene, serine/threonine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.417
BRAF	IGF1	ENSCHIP00000019379	ENSCHIP00000020185	B-Raf proto-oncogene, serine/threonine kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.510
BRAF	IQGAP3	ENSCHIP00000019379	ENSCHIP00000032459	B-Raf proto-oncogene, serine/threonine kinase.	IQ motif containing GTPase activating protein 3.	0.502
BRAF	MAP2K1	ENSCHIP00000019379	ENSCHIP00000024037	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.942
BRAF	MAP2K2	ENSCHIP00000019379	ENSCHIP00000013571	B-Raf proto-oncogene, serine/threonine kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.932
BRAF	MAPK1	ENSCHIP00000019379	ENSCHIP00000000204	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.865
BRAF	MAPK3	ENSCHIP00000019379	ENSCHIP00000015503	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.847
BRAF	SPRY2	ENSCHIP00000019379	ENSCHIP00000004142	B-Raf proto-oncogene, serine/threonine kinase.	Sprouty RTK signaling antagonist 2.	0.949
EDN1	AVP	ENSCHIP00000008821	ENSCHIP00000006784	Endothelin 1.	Arginine vasopressin; Belongs to the vasopressin/oxytocin family.	0.502
EDN1	FGF2	ENSCHIP00000008821	ENSCHIP00000019134	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.697
EDN1	IGF1	ENSCHIP00000008821	ENSCHIP00000020185	Endothelin 1.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.541
EDN1	KDR	ENSCHIP00000008821	ENSCHIP00000003056	Endothelin 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.643
EDN1	TLR4	ENSCHIP00000008821	ENSCHIP00000019512	Endothelin 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.428
FGF10	FGF18	ENSCHIP00000010028	ENSCHIP00000008198	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.584
FGF10	FGF2	ENSCHIP00000010028	ENSCHIP00000019134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.497
FGF10	FGF23	ENSCHIP00000010028	ENSCHIP00000016617	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.666