STRINGSTRING
THPO THPO FBXW9 FBXW9 ALKAL1 ALKAL1 FGF1 FGF1 CSF1R CSF1R APP APP LOC102180880 LOC102180880 F2RL1 F2RL1 ENSCHIP00000032320 ENSCHIP00000032320 IL26 IL26 HTR2B HTR2B PTK2B PTK2B CCL25 CCL25 ENSCHIP00000031987 ENSCHIP00000031987 LOC102190981 LOC102190981 RAPGEF2 RAPGEF2 ERBB4 ERBB4 CCL21 CCL21 PDGFB PDGFB TNFRSF11A TNFRSF11A FGF21 FGF21 SEMA7A SEMA7A CCN2 CCN2 PDGFRB PDGFRB NOD2 NOD2 APELA APELA PRKCA PRKCA FBXW7 FBXW7 ENSCHIP00000029027 ENSCHIP00000029027 CX3CL1 CX3CL1 CXCL17 CXCL17 FERMT2 FERMT2 CCL2 CCL2 FSHR FSHR CCL26 CCL26 PRXL2C PRXL2C FGFR4 FGFR4 ABCA7 ABCA7 PYCARD PYCARD GAREM2 GAREM2 CCL22 CCL22 NOTCH2 NOTCH2 GPER1 GPER1 SLC30A10 SLC30A10 PTPRC PTPRC F2R F2R SERPINF2 SERPINF2 GLIPR2 GLIPR2 APOE APOE NDRG4 NDRG4 ABL1 ABL1 NOX4 NOX4 CD44 CD44 NPTN NPTN LOC102170772 LOC102170772 MAP2K1 MAP2K1 GCG GCG PRKD2 PRKD2 NOTCH1 NOTCH1 BMP4 BMP4 CAVIN3 CAVIN3 DSTYK DSTYK EGFR EGFR HTR2C HTR2C ALKAL2 ALKAL2 CCL8 CCL8 MT3 MT3 PTPN11 PTPN11 NOD1 NOD1 NPNT NPNT PLA2G5 PLA2G5 RAMP3 RAMP3 IGF1 IGF1 RIPK2 RIPK2 TLR4 TLR4 BRAF BRAF CCL19 CCL19 BMPER BMPER FGF2 FGF2 FGA FGA ENSCHIP00000018542 ENSCHIP00000018542 RAP1A RAP1A PDE8A PDE8A OPRM1 OPRM1 HAVCR2 HAVCR2 PHB2 PHB2 MFHAS1 MFHAS1 LOC102181154 LOC102181154 LOC102190717 LOC102190717 FGF8 FGF8 HTR2A HTR2A FGF23 FGF23 CCL5 CCL5 GPR55 GPR55 C5AR1 C5AR1 MAPK3 MAPK3 PDGFC PDGFC ARRB2 ARRB2 ANGPT1 ANGPT1 GAS6 GAS6 CCL20 CCL20 CCL14 CCL14 TNFSF11 TNFSF11 FGB FGB FGG FGG PTPN22 PTPN22 CD74 CD74 TEK TEK AGER AGER DNAJC27 DNAJC27 CARD9 CARD9 TRPV4 TRPV4 FLT4 FLT4 ARRB1 ARRB1 FGF19 FGF19 CCL11 CCL11 BMP2 BMP2 SHC1 SHC1 GPR183 GPR183 FGF10 FGF10 ARHGAP8 ARHGAP8 HAND2 HAND2 PHB PHB ENSCHIP00000008932 ENSCHIP00000008932 TGFB1 TGFB1 FFAR4 FFAR4 FGF18 FGF18 HCRTR1 HCRTR1 CCL17 CCL17 PRKCZ PRKCZ CCL24 CCL24 CIB1 CIB1 FGF4 FGF4 CD4 CD4 RASGRP1 RASGRP1 SLAMF1 SLAMF1 MAP3K12 MAP3K12 LOC100861326 LOC100861326 SPRY2 SPRY2 TREM2 TREM2 FGFR3 FGFR3 KDR KDR PDGFD PDGFD CRKL CRKL SRC SRC FGA-2 FGA-2 PDGFRA PDGFRA P2RY6 P2RY6 HRAS HRAS CCL16 CCL16 JUN JUN LOC108638246 LOC108638246 DENND2B DENND2B CHI3L1 CHI3L1 C5AR2 C5AR2 ACKR3 ACKR3 TPBG TPBG CCL1 CCL1 GAREM1 GAREM1 NODAL NODAL ADCYAP1 ADCYAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THPOThrombopoietin. (353 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
ALKAL1Uncharacterized protein. (93 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
APPAmyloid beta precursor protein. (770 aa)
LOC102180880C-C motif chemokine. (92 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ENSCHIP00000032320Prohibitin. (189 aa)
IL26Interleukin 26. (169 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
ENSCHIP00000031987Non-specific serine/threonine protein kinase. (199 aa)
LOC102190981SCY domain-containing protein. (109 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1675 aa)
ERBB4Protein kinase domain-containing protein. (462 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TNFRSF11ATNF receptor superfamily member 11a. (588 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
CCN2Cellular communication network factor 2. (349 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
NOD2Uncharacterized protein. (982 aa)
APELAUncharacterized protein. (54 aa)
PRKCAUncharacterized protein. (605 aa)
FBXW7F-box and WD repeat domain containing 7. (705 aa)
ENSCHIP00000029027SCP domain-containing protein. (128 aa)
CX3CL1SCY domain-containing protein. (430 aa)
CXCL17Uncharacterized protein. (119 aa)
FERMT2Fermitin family member 2. (680 aa)
CCL2C-C motif chemokine. (98 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (670 aa)
CCL26C-C motif chemokine. (94 aa)
PRXL2CPeroxiredoxin like 2C. (228 aa)
FGFR4Fibroblast growth factor receptor. (870 aa)
ABCA7ATP binding cassette subfamily A member 7. (2152 aa)
PYCARDPYD and CARD domain containing. (196 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (868 aa)
CCL22C-C motif chemokine. (93 aa)
NOTCH2Notch receptor 2. (2471 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SLC30A10Solute carrier family 30 member 10. (486 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (476 aa)
GLIPR2SCP domain-containing protein; Belongs to the CRISP family. (162 aa)
APOEApolipoprotein E. (326 aa)
NDRG4NDRG family member 4. (391 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
NOX4NADPH oxidase 4. (578 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
NPTNNeuroplastin. (361 aa)
LOC102170772C-C motif chemokine. (105 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
GCGGlucagon. (180 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
NOTCH1Notch receptor 1. (2508 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CAVIN3Caveolae associated protein 3. (260 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (928 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
HTR2C5-hydroxytryptamine receptor 2C. (457 aa)
ALKAL2ALK and LTK ligand 2. (151 aa)
CCL8C-C motif chemokine. (99 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (954 aa)
NPNTNephronectin. (606 aa)
PLA2G5Phospholipase A(2). (138 aa)
RAMP3Receptor activity modifying protein 3. (147 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (774 aa)
CCL19C-C motif chemokine. (102 aa)
BMPERBMP binding endothelial regulator. (685 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (618 aa)
ENSCHIP00000018542SCY domain-containing protein. (102 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PDE8APhosphodiesterase. (832 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
PHB2Prohibitin. (289 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
LOC102181154C-C motif chemokine. (93 aa)
LOC102190717SCY domain-containing protein. (112 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
CCL5C-C motif chemokine. (91 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (329 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
ARRB2Arrestin beta 2. (420 aa)
ANGPT1Angiopoietin 1. (488 aa)
GAS6Growth arrest specific 6. (671 aa)
CCL20C-C motif chemokine. (96 aa)
CCL14C-C motif chemokine ligand 14. (94 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (494 aa)
FGGFibrinogen gamma chain. (442 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (795 aa)
CD74CD74 molecule. (261 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
DNAJC27DnaJ heat shock protein family (Hsp40) member C27. (296 aa)
CARD9Caspase recruitment domain family member 9. (519 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
ARRB1Arrestin beta 1. (418 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
CCL11C-C motif chemokine. (97 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
SHC1SHC adaptor protein 1. (583 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (356 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
ARHGAP8Uncharacterized protein. (494 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
PHBProhibitin. (272 aa)
ENSCHIP00000008932Uncharacterized protein. (166 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FFAR4Free fatty acid receptor 4. (378 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CCL17C-C motif chemokine. (102 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
CCL24C-C motif chemokine ligand 24. (116 aa)
CIB1Calcium and integrin binding 1. (191 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CD4CD4 molecule. (455 aa)
RASGRP1RAS guanyl releasing protein 1. (773 aa)
SLAMF1Ig-like domain-containing protein. (338 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
LOC100861326Uncharacterized protein. (400 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
SRCTyrosine-protein kinase. (538 aa)
FGA-2Fibrinogen C-terminal domain-containing protein. (206 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CCL16C-C motif chemokine. (99 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
LOC108638246C-C motif chemokine. (93 aa)
DENND2BSuppression of tumorigenicity 5. (1137 aa)
CHI3L1Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (391 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TPBGTrophoblast glycoprotein. (420 aa)
CCL1SCY domain-containing protein. (93 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (872 aa)
NODALNodal growth differentiation factor. (346 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (186 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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