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| | NOTCH1 | Notch receptor 1. (2508 aa) |
| | IGFBPL1 | Insulin like growth factor binding protein like 1. (274 aa) |
| | CCDC47 | Coiled-coil domain containing 47. (483 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (622 aa) |
| | BPIFC | BPI fold containing family C. (508 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (785 aa) |
| | IL36RN | Interleukin-1. (161 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | GIT1 | GIT ArfGAP 1. (738 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (599 aa) |
| | PDCD4 | Programmed cell death 4. (513 aa) |
| | TLR6 | Toll-like receptor. (966 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa) |
| | NFKBIB | NFKB inhibitor beta. (364 aa) |
| | PLSCR4 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (333 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1154 aa) |
| | DEFB124 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa) |
| | PYCARD | PYD and CARD domain containing. (196 aa) |
| | ZFP36 | ZFP36 ring finger protein. (325 aa) |
| | ATG10 | Autophagy related 10. (234 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa) |
| | SELENOS | Uncharacterized protein. (188 aa) |
| | SHPK | FGGY_N domain-containing protein. (478 aa) |
| | PPBP | C-X-C motif chemokine. (119 aa) |
| | CCL2 | C-C motif chemokine. (98 aa) |
| | XBP1 | BZIP domain-containing protein. (261 aa) |
| | MRC1 | Mannose receptor C-type 1. (1455 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | LOC102182683 | C-X-C motif chemokine. (109 aa) |
| | ENSCHIP00000028669 | Uncharacterized protein. (161 aa) |
| | IL36G | Interleukin-1. (171 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (296 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | NOD2 | Uncharacterized protein. (982 aa) |
| | HADHB | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (617 aa) |
| | HSPA5 | Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family. (655 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa) |
| | ENSCHIP00000031698 | Uncharacterized protein. (321 aa) |
| | ENSCHIP00000031750 | SMC_N domain-containing protein. (189 aa) |
| | ENSCHIP00000031771 | C2 domain-containing protein. (204 aa) |
| | ARID5A | AT-rich interaction domain 5A. (591 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1377 aa) |
| | IL1F10 | Interleukin-1. (152 aa) |
| | TMCO1 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family. (188 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (219 aa) |
| | ENSCHIP00000032824 | Uncharacterized protein. (93 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (708 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (300 aa) |
| | IRF8 | Interferon regulatory factor 8. (426 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa) |
| | NFKBIL1 | NFKB inhibitor like 1. (381 aa) |
| | IL37 | Interleukin-1. (265 aa) |
| | FAM49B | Uncharacterized protein. (350 aa) |
| | DAB2IP | DAB2 interacting protein. (1198 aa) |
| | PDE4B | Phosphodiesterase. (659 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (725 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa) |
| | FCAR | Fc fragment of IgA receptor. (290 aa) |
| | LOC102186320 | Uncharacterized protein. (479 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (230 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1188 aa) |
| | CLEC7A | C-type lectin domain containing 7A. (247 aa) |
| | CD80 | CD80 molecule. (302 aa) |
| | ENSCHIP00000006481 | ANK_REP_REGION domain-containing protein. (123 aa) |
| | CXCL5 | C-X-C motif chemokine. (119 aa) |
| | IL36B | Interleukin-1. (158 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1126 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa) |
| | TICAM2 | TIR domain-containing protein. (232 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (230 aa) |
| | PAF1 | Uncharacterized protein. (501 aa) |
| | KLRK1 | Killer cell lectin like receptor K1. (208 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | PTAFR | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). (352 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (718 aa) |
| | SYK | Spleen associated tyrosine kinase. (636 aa) |
| | AICDA | Activation induced cytidine deaminase. (199 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (458 aa) |
| | PPP1R15B | Protein phosphatase 1 regulatory subunit 15B. (698 aa) |
| | ENSCHIP00000011371 | Uncharacterized protein. (193 aa) |
| | NR1H3 | Uncharacterized protein. (447 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (429 aa) |
| | RHOA | Ras-like protein family member A. (193 aa) |
| | LITAF | Lipopolysaccharide induced TNF factor. (161 aa) |
| | LOC102182395 | C-X-C motif chemokine. (103 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (376 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | RARA | Retinoic acid receptor alpha. (462 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa) |
| | PLAA | Phospholipase A2 activating protein. (796 aa) |
| | LOC102181854 | C-X-C motif chemokine. (117 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (571 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (469 aa) |
| | CXCL10 | C-X-C motif chemokine. (102 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa) |
| | CD86 | Ig-like domain-containing protein. (289 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | GFI1 | Growth factor independent 1 transcriptional repressor. (420 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (580 aa) |
| | BPI | Uncharacterized protein. (483 aa) |
| | MEF2C | MADS-box domain-containing protein. (441 aa) |
| | FBH1 | F-box DNA helicase 1. (1048 aa) |
| | MALT1 | MALT1 paracaspase. (830 aa) |
| | LOC102170474 | Uncharacterized protein. (238 aa) |
| | NUGGC | Nuclear GTPase, germinal center associated. (794 aa) |
| | CXCL13 | C-X-C motif chemokine. (109 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa) |
| | LOC102181154 | C-C motif chemokine. (93 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1752 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (280 aa) |
| | CD274 | CD274 molecule. (289 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa) |
| | CXCL11 | C-X-C motif chemokine. (87 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (616 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa) |
| | ENSCHIP00000018091 | Uncharacterized protein. (55 aa) |
| | TXNIP | Thioredoxin interacting protein. (391 aa) |
| | IRF3 | Interferon regulatory factor 3. (418 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | PRKCE | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa) |
| | ENSCHIP00000019700 | DUF4939 domain-containing protein. (113 aa) |
| | RTL8C | DUF4939 domain-containing protein. (113 aa) |
| | ANKRD1 | Ankyrin repeat domain 1. (319 aa) |
| | LOC108634461 | Protein FAM127. (113 aa) |
| | LOC102185270 | Protein FAM127. (113 aa) |
| | LDOC1 | LDOC1 regulator of NFKB signaling. (145 aa) |
| | LOC102178993 | C-X-C motif chemokine. (101 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (821 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | SPI1 | Spi-1 proto-oncogene. (270 aa) |
| | TNFSF4 | TNF superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa) |
| | CD6 | CD6 molecule. (672 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1130 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | MTDH | Metadherin. (583 aa) |
| | AXL | AXL receptor tyrosine kinase. (887 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (471 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (459 aa) |
| | IL36A | Interleukin-1. (176 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | PLSCR3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (297 aa) |
