(95 nodes) Nephron epithelium development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	HOXA11	Homeobox A11. (317 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	PAX2	Paired box 2. (467 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (978 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	PAX8	Paired box 8. (457 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	NPNT	Nephronectin. (606 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	PECAM1	Platelet and endothelial cell adhesion molecule 1. (739 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	IRX1	Iroquois homeobox 1. (475 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (672 aa)
	GREB1	Uncharacterized protein. (1944 aa)
	ILK	Integrin linked kinase. (452 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SOX8	SRY-box transcription factor 8. (534 aa)
	ENSCHIP00000016631	HARE-HTH domain-containing protein. (59 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4303 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	MEF2C	MADS-box domain-containing protein. (441 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	FAT4	FAT atypical cadherin 4. (4982 aa)
	TCF21	Transcription factor 21. (179 aa)
	UMOD	Uromodulin. (643 aa)
	LAMB2	Laminin subunit beta 2. (1802 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	IRX3	Iroquois homeobox 3. (503 aa)
	NPHS1	NPHS1 adhesion molecule, nephrin. (1233 aa)
	PTCH1	Patched 1. (1453 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	MYO1E	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1113 aa)
	KLHL3	Kelch like family member 3. (610 aa)
	WT1	WT1 transcription factor. (450 aa)
	DCHS1	Dachsous cadherin-related 1. (3258 aa)
	BMP2	TGF_BETA_2 domain-containing protein. (381 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (315 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
	COMMD5	COMM domain containing 5. (224 aa)
	IRX2	Iroquois homeobox 2. (482 aa)
	LAMA5	Laminin subunit alpha 5. (2263 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	GREM1	Gremlin. (184 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1279 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1216 aa)
	SIX2	SIX homeobox 2. (296 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
	ENSCHIP00000005724	Uncharacterized protein. (62 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
	GZF1	GDNF inducible zinc finger protein 1. (710 aa)
	TFAP2B	Transcription factor AP-2 beta. (476 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (383 aa)
	TMEM59L	Transmembrane protein 59 like. (349 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1235 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	CALB1	Calbindin 1. (261 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	FMN1	Formin 1. (1435 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	LHX1	LIM homeobox 1. (406 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	GDNF	Glial cell derived neurotrophic factor. (211 aa)
	MTSS1	MTSS I-BAR domain containing 1. (737 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	HS3ST3B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (388 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (901 aa)
	SIX1	SIX homeobox 1. (284 aa)
	ENSCHIP00000030069	PDZ domain-containing protein. (123 aa)
	GATA3	GATA binding protein 3. (467 aa)
	AHI1	Abelson helper integration site 1. (1194 aa)
	ASXL1	ASXL transcriptional regulator 1. (1536 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1911 aa)
	SALL1	Spalt like transcription factor 1. (1317 aa)
	PROM1	Prominin 1. (855 aa)
	HS2ST1	Uncharacterized protein. (356 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2112 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	IRX1	ENSCHIP00000006836	ENSCHIP00000018410	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 1.	0.494
AHI1	CTNNB1	ENSCHIP00000030650	ENSCHIP00000031016	Abelson helper integration site 1.	Catenin beta 1.	0.468
AQP1	AQP11	ENSCHIP00000032801	ENSCHIP00000011474	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.826
AQP1	CALB1	ENSCHIP00000032801	ENSCHIP00000023496	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Calbindin 1.	0.401
AQP1	NPHS2	ENSCHIP00000032801	ENSCHIP00000001614	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	NPHS2 stomatin family member, podocin.	0.498
AQP1	UMOD	ENSCHIP00000032801	ENSCHIP00000014278	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uromodulin.	0.551
AQP1	WT1	ENSCHIP00000032801	ENSCHIP00000010586	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	WT1 transcription factor.	0.403
AQP11	AQP1	ENSCHIP00000011474	ENSCHIP00000032801	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.826
ASXL1	WT1	ENSCHIP00000030711	ENSCHIP00000010586	ASXL transcriptional regulator 1.	WT1 transcription factor.	0.581
BCL2	CTNNB1	ENSCHIP00000015831	ENSCHIP00000031016	BH4_2 domain-containing protein.	Catenin beta 1.	0.820
BCL2	FGF2	ENSCHIP00000015831	ENSCHIP00000019134	BH4_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.608
BCL2	NOTCH1	ENSCHIP00000015831	ENSCHIP00000023681	BH4_2 domain-containing protein.	Notch receptor 1.	0.664
BCL2	NOTCH2	ENSCHIP00000015831	ENSCHIP00000026116	BH4_2 domain-containing protein.	Notch receptor 2.	0.418
BCL2	PECAM1	ENSCHIP00000015831	ENSCHIP00000020243	BH4_2 domain-containing protein.	Platelet and endothelial cell adhesion molecule 1.	0.547
BCL2	SHH	ENSCHIP00000015831	ENSCHIP00000027767	BH4_2 domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.490
BCL2	SMAD4	ENSCHIP00000015831	ENSCHIP00000020573	BH4_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.512
BCL2	SMO	ENSCHIP00000015831	ENSCHIP00000027079	BH4_2 domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.442
BCL2	WT1	ENSCHIP00000015831	ENSCHIP00000010586	BH4_2 domain-containing protein.	WT1 transcription factor.	0.467
BMP2	BMP4	ENSCHIP00000010414	ENSCHIP00000023678	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 4.	0.931
BMP2	CTNNB1	ENSCHIP00000010414	ENSCHIP00000031016	TGF_BETA_2 domain-containing protein.	Catenin beta 1.	0.701