(12 nodes) Kidney mesenchyme development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIX4	SIX homeobox 4. (784 aa)
	LOC102176871	Uncharacterized protein. (921 aa)
	TCF21	Transcription factor 21. (179 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (978 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	SIX1	SIX homeobox 1. (284 aa)
	AMER1	Uncharacterized protein. (1101 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	SIX2	SIX homeobox 2. (296 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SIX1	ENSCHIP00000023678	ENSCHIP00000029952	Bone morphogenetic protein 4.	SIX homeobox 1.	0.531
BMP4	SMAD4	ENSCHIP00000023678	ENSCHIP00000020573	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.949
BMP7	BMP4	ENSCHIP00000006043	ENSCHIP00000023678	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.778
BMP7	SHH	ENSCHIP00000006043	ENSCHIP00000027767	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.697
BMP7	SIX2	ENSCHIP00000006043	ENSCHIP00000006591	Bone morphogenetic protein 7.	SIX homeobox 2.	0.532
BMP7	SMAD4	ENSCHIP00000006043	ENSCHIP00000020573	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.831
PKD2	SHH	ENSCHIP00000022411	ENSCHIP00000027767	Polycystin 2, transient receptor potential cation channel.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.411
SHH	BMP4	ENSCHIP00000027767	ENSCHIP00000023678	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.909
SHH	BMP7	ENSCHIP00000027767	ENSCHIP00000006043	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.697
SHH	PKD2	ENSCHIP00000027767	ENSCHIP00000022411	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Polycystin 2, transient receptor potential cation channel.	0.411
SHH	SMAD4	ENSCHIP00000027767	ENSCHIP00000020573	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Mothers against decapentaplegic homolog.	0.465
SIX1	BMP4	ENSCHIP00000029952	ENSCHIP00000023678	SIX homeobox 1.	Bone morphogenetic protein 4.	0.531
SIX2	BMP7	ENSCHIP00000006591	ENSCHIP00000006043	SIX homeobox 2.	Bone morphogenetic protein 7.	0.532
SMAD4	BMP4	ENSCHIP00000020573	ENSCHIP00000023678	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.949
SMAD4	BMP7	ENSCHIP00000020573	ENSCHIP00000006043	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 7.	0.831
SMAD4	SHH	ENSCHIP00000020573	ENSCHIP00000027767	Mothers against decapentaplegic homolog.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.465