STRINGSTRING
RUNX2 RUNX2 ARIH2 ARIH2 HMX2 HMX2 NES NES GBA GBA CTNNB1 CTNNB1 SHB SHB HOXB4 HOXB4 TP53 TP53 BABAM1 BABAM1 KDF1 KDF1 CTC1 CTC1 TP63 TP63 SHH SHH RARG RARG ERCC2 ERCC2 YTHDF2 YTHDF2 SFRP2 SFRP2 CD109 CD109 XRCC5 XRCC5 WNT11 WNT11 SOX9 SOX9 SART3 SART3 BRCA2 BRCA2 ETV6 ETV6 NR2E1 NR2E1 FGF9 FGF9 SCRG1 SCRG1 AXIN2 AXIN2 OSR2 OSR2 WNT1 WNT1 WNT3 WNT3 CDKN2C CDKN2C TRIM71 TRIM71 FGF2 FGF2 BYSL BYSL YAP1 YAP1 OVOL1 OVOL1 FGF8 FGF8 WNT5A WNT5A SHOX2 SHOX2 ENSCHIP00000014888 ENSCHIP00000014888 IRF6 IRF6 GLI3 GLI3 ELL3 ELL3 WNT7B WNT7B HOXA3 HOXA3 PTCH1 PTCH1 FGF10 FGF10 TBX3 TBX3 NFIB NFIB TGFB1 TGFB1 RARB RARB RNF43 RNF43 IFT20 IFT20 CEP120 CEP120 WNT10B WNT10B NF1 NF1 FGF4 FGF4 SIX2 SIX2 PRRX1 PRRX1 WNT2B WNT2B KDR KDR IRS2 IRS2 SFN SFN LIG4 LIG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUNX2RUNX family transcription factor 2. (585 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
HMX2H6 family homeobox 2. (274 aa)
NESNestin; Belongs to the intermediate filament family. (1606 aa)
GBAGlucosylceramidase. (536 aa)
CTNNB1Catenin beta 1. (781 aa)
SHBSH2 domain-containing protein. (507 aa)
HOXB4Homeobox B4. (251 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
RARGRetinoic acid receptor gamma. (458 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (582 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
CD109CD109 molecule. (1446 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX9SRY-box transcription factor 9. (525 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (981 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
ETV6ETS variant 6. (452 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
AXIN2Axin 2. (844 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
TRIM71Tripartite motif containing 71. (876 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
BYSLBystin like. (600 aa)
YAP1Yes associated protein 1. (503 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SHOX2Short stature homeobox 2. (319 aa)
ENSCHIP00000014888IRF tryptophan pentad repeat domain-containing protein. (244 aa)
IRF6IRF tryptophan pentad repeat domain-containing protein. (467 aa)
GLI3GLI family zinc finger 3. (1614 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
HOXA3Homeobox A3. (437 aa)
PTCH1Patched 1. (1453 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
TBX3T-box transcription factor 3. (749 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RARBRetinoic acid receptor beta. (448 aa)
RNF43RING-type domain-containing protein. (813 aa)
IFT20Intraflagellar transport 20. (156 aa)
CEP120Centrosomal protein 120. (987 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
NF1Neurofibromin 1. (2848 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SIX2SIX homeobox 2. (296 aa)
PRRX1Paired related homeobox 1. (245 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
LIG4DNA ligase. (911 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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