STRINGSTRING
IRF6 IRF6 ENSCHIP00000033272 ENSCHIP00000033272 HMX2 HMX2 KAT7 KAT7 CTNNB1 CTNNB1 SOX18 SOX18 KITLG KITLG TP53 TP53 SOX11 SOX11 CCNE1 CCNE1 KDF1 KDF1 VEGFC VEGFC PIM1 PIM1 FERMT2 FERMT2 TP63 TP63 LTBP3 LTBP3 SHH SHH RARG RARG EPCAM EPCAM ZFP36L1 ZFP36L1 PTPRC PTPRC CD109 CD109 WNT11 WNT11 SOX9 SOX9 NOTCH1 NOTCH1 SOX17 SOX17 NR2E1 NR2E1 FGF9 FGF9 DGCR8 DGCR8 OSR2 OSR2 CITED1 CITED1 WNT1 WNT1 CDKN2C CDKN2C FGF2 FGF2 FBLN1 FBLN1 PDCD2 PDCD2 THPO THPO FERMT1 FERMT1 YAP1 YAP1 OVOL1 OVOL1 FGF8 FGF8 EIF2AK2 EIF2AK2 WNT5A WNT5A SHOX2 SHOX2 RUNX2 RUNX2 ENSCHIP00000014888 ENSCHIP00000014888 GLI3 GLI3 ELL3 ELL3 HOXA3 HOXA3 NF2 NF2 HMGA2 HMGA2 PTCH1 PTCH1 FGF10 FGF10 TBX3 TBX3 NFIB NFIB TGFB1 TGFB1 RARB RARB ATXN1L ATXN1L AGO3 AGO3 TGFBR2 TGFBR2 WNT10B WNT10B NF1 NF1 FGF4 FGF4 PRRX1 PRRX1 TERT TERT KDR KDR HNRNPU HNRNPU GJA1 GJA1 IRS2 IRS2 SFN SFN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF6IRF tryptophan pentad repeat domain-containing protein. (467 aa)
ENSCHIP00000033272FERM domain-containing protein. (580 aa)
HMX2H6 family homeobox 2. (274 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
CTNNB1Catenin beta 1. (781 aa)
SOX18SRY-box transcription factor 18. (393 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SOX11Transcription factor SOX. (444 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (390 aa)
FERMT2Fermitin family member 2. (680 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1294 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
RARGRetinoic acid receptor gamma. (458 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
CD109CD109 molecule. (1446 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX9SRY-box transcription factor 9. (525 aa)
NOTCH1Notch receptor 1. (2508 aa)
SOX17SRY-box transcription factor 17. (410 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DGCR8DGCR8 microprocessor complex subunit. (764 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (247 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (713 aa)
PDCD2Programmed cell death 2. (344 aa)
THPOThrombopoietin. (353 aa)
FERMT1Fermitin family member 1. (679 aa)
YAP1Yes associated protein 1. (503 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (543 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SHOX2Short stature homeobox 2. (319 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
ENSCHIP00000014888IRF tryptophan pentad repeat domain-containing protein. (244 aa)
GLI3GLI family zinc finger 3. (1614 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
HOXA3Homeobox A3. (437 aa)
NF2FERM domain-containing protein. (612 aa)
HMGA2Uncharacterized protein. (104 aa)
PTCH1Patched 1. (1453 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
TBX3T-box transcription factor 3. (749 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RARBRetinoic acid receptor beta. (448 aa)
ATXN1LAtaxin 1 like. (688 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
NF1Neurofibromin 1. (2848 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PRRX1Paired related homeobox 1. (245 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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