(9 nodes) Cell proliferation involved in kidney development network (Capra hircus)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	PTCH1	Patched 1. (1453 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
	BMP2	TGF_BETA_2 domain-containing protein. (381 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSCHIP00000010414	ENSCHIP00000023678	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 4.	0.931
BMP2	BMP7	ENSCHIP00000010414	ENSCHIP00000006043	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 7.	0.679
BMP2	PTCH1	ENSCHIP00000010414	ENSCHIP00000011891	TGF_BETA_2 domain-containing protein.	Patched 1.	0.475
BMP2	SHH	ENSCHIP00000010414	ENSCHIP00000027767	TGF_BETA_2 domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.543
BMP4	BMP2	ENSCHIP00000023678	ENSCHIP00000010414	Bone morphogenetic protein 4.	TGF_BETA_2 domain-containing protein.	0.931
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	GPC3	ENSCHIP00000023678	ENSCHIP00000019503	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.415
BMP4	PTCH1	ENSCHIP00000023678	ENSCHIP00000011891	Bone morphogenetic protein 4.	Patched 1.	0.737
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP7	BMP2	ENSCHIP00000006043	ENSCHIP00000010414	Bone morphogenetic protein 7.	TGF_BETA_2 domain-containing protein.	0.679
BMP7	BMP4	ENSCHIP00000006043	ENSCHIP00000023678	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.778
BMP7	SHH	ENSCHIP00000006043	ENSCHIP00000027767	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.697
GPC3	BMP4	ENSCHIP00000019503	ENSCHIP00000023678	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Bone morphogenetic protein 4.	0.415
GPC3	PTCH1	ENSCHIP00000019503	ENSCHIP00000011891	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Patched 1.	0.456
GPC3	SHH	ENSCHIP00000019503	ENSCHIP00000027767	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.960
PTCH1	BMP2	ENSCHIP00000011891	ENSCHIP00000010414	Patched 1.	TGF_BETA_2 domain-containing protein.	0.475
PTCH1	BMP4	ENSCHIP00000011891	ENSCHIP00000023678	Patched 1.	Bone morphogenetic protein 4.	0.737
PTCH1	GPC3	ENSCHIP00000011891	ENSCHIP00000019503	Patched 1.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.456
PTCH1	SHH	ENSCHIP00000011891	ENSCHIP00000027767	Patched 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.999
SHH	BMP2	ENSCHIP00000027767	ENSCHIP00000010414	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	TGF_BETA_2 domain-containing protein.	0.543