(107 nodes) Epithelial tube formation network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (833 aa)
	GRHL2	Grainyhead like transcription factor 2. (622 aa)
	IRX1	Iroquois homeobox 1. (475 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1704 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2710 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	TSC1	Uncharacterized protein. (1158 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1261 aa)
	TRIM71	Tripartite motif containing 71. (876 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	GRHL3	Grainyhead like transcription factor 3. (600 aa)
	SCRIB	Scribble planar cell polarity protein. (1582 aa)
	SPINT2	Serine peptidase inhibitor, Kunitz type 2. (250 aa)
	ENSCHIP00000021337	Uncharacterized protein. (137 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	CC2D2A	Coiled-coil and C2 domain containing 2A. (1616 aa)
	LRRC1	Leucine rich repeat containing 1. (517 aa)
	SHROOM3	Shroom family member 3. (1989 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	FOLR1	Folate_rec domain-containing protein. (251 aa)
	FUZ	Fuzzy planar cell polarity protein. (419 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	KDM2B	Lysine demethylase 2B. (1309 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
	IFT52	Intraflagellar transport 52. (448 aa)
	CLUAP1	Clusterin associated protein 1. (438 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1321 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	GDNF	Glial cell derived neurotrophic factor. (211 aa)
	GLMN	Glomulin, FKBP associated protein. (592 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	MKS1	MKS transition zone complex subunit 1. (645 aa)
	HESX1	HESX homeobox 1. (185 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	LHX2	Uncharacterized protein. (422 aa)
	SIX1	SIX homeobox 1. (284 aa)
	GATA3	GATA binding protein 3. (467 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (508 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	TEAD2	TEA domain transcription factor 2. (448 aa)
	KDM6A	Lysine demethylase 6A. (1386 aa)
	SALL4	Spalt like transcription factor 4. (1063 aa)
	HS2ST1	Uncharacterized protein. (356 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
	ST14	Suppression of tumorigenicity 14. (890 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (488 aa)
	LUZP1	Leucine zipper protein 1. (1071 aa)
	MED12	Med12 domain-containing protein. (2040 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	LMO4	LIM domain only 4. (185 aa)
	ENSCHIP00000000097	Med12-PQL domain-containing protein. (315 aa)
	NODAL	Nodal growth differentiation factor. (346 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (219 aa)
	STK4	Serine/threonine kinase 4. (487 aa)
	TCAP	Uncharacterized protein. (167 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	GREM1	Gremlin. (184 aa)
	STK3	Serine/threonine kinase 3. (495 aa)
	TBXT	T-box transcription factor T. (435 aa)
	IRX2	Iroquois homeobox 2. (482 aa)
	GDF7	Growth differentiation factor 7. (451 aa)
	BCL10	BCL10 immune signaling adaptor. (230 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	VASP	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (834 aa)
	TCTN1	Tectonic family member 1. (592 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	DVL3	Dishevelled segment polarity protein 3. (716 aa)
	SOX4	SRY-box transcription factor 4. (504 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	PTCH1	Patched 1. (1453 aa)
	BRD2	Bromodomain containing 2. (803 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	SFRP1	Secreted frizzled related protein 1. (308 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1449 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	IRX3	Iroquois homeobox 3. (503 aa)
	LIAS	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
	BBS4	Bardet-Biedl syndrome 4. (519 aa)
	DVL1	Dishevelled segment polarity protein 1. (682 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
	SOX8	SRY-box transcription factor 8. (534 aa)
	PHACTR4	Phosphatase and actin regulator. (714 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CTNNB1	ENSCHIP00000024651	ENSCHIP00000031016	Tyrosine-protein kinase.	Catenin beta 1.	0.622
ABL1	VASP	ENSCHIP00000024651	ENSCHIP00000009179	Tyrosine-protein kinase.	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.	0.570
APAF1	CASP3	ENSCHIP00000031955	ENSCHIP00000011490	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.997
BBS4	CLUAP1	ENSCHIP00000013678	ENSCHIP00000025634	Bardet-Biedl syndrome 4.	Clusterin associated protein 1.	0.612
BBS4	IFT52	ENSCHIP00000013678	ENSCHIP00000025435	Bardet-Biedl syndrome 4.	Intraflagellar transport 52.	0.648
BBS4	IFT57	ENSCHIP00000013678	ENSCHIP00000019103	Bardet-Biedl syndrome 4.	Intraflagellar transport 57.	0.870
BCL10	TRAF6	ENSCHIP00000008353	ENSCHIP00000015162	BCL10 immune signaling adaptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.943
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	CASP3	ENSCHIP00000023678	ENSCHIP00000011490	Bone morphogenetic protein 4.	Caspase 3; Belongs to the peptidase C14A family.	0.488
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	FGF10	ENSCHIP00000023678	ENSCHIP00000010028	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.887
BMP4	FGF8	ENSCHIP00000023678	ENSCHIP00000016903	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.763
BMP4	GATA3	ENSCHIP00000023678	ENSCHIP00000030187	Bone morphogenetic protein 4.	GATA binding protein 3.	0.544
BMP4	GDNF	ENSCHIP00000023678	ENSCHIP00000027133	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.603
BMP4	GREM1	ENSCHIP00000023678	ENSCHIP00000006985	Bone morphogenetic protein 4.	Gremlin.	0.946
BMP4	LHX2	ENSCHIP00000023678	ENSCHIP00000029613	Bone morphogenetic protein 4.	Uncharacterized protein.	0.493
BMP4	NOG	ENSCHIP00000023678	ENSCHIP00000005264	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.999
BMP4	PTCH1	ENSCHIP00000023678	ENSCHIP00000011891	Bone morphogenetic protein 4.	Patched 1.	0.737
BMP4	RET	ENSCHIP00000023678	ENSCHIP00000024240	Bone morphogenetic protein 4.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.406
BMP4	SALL4	ENSCHIP00000023678	ENSCHIP00000032217	Bone morphogenetic protein 4.	Spalt like transcription factor 4.	0.414