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| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (844 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1145 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | ENSCHIP00000030787 | Uncharacterized protein. (140 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (973 aa) |
| | ENSCHIP00000030535 | zf-RING_14 domain-containing protein. (149 aa) |
| | LRP4 | LDL receptor related protein 4. (1901 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (320 aa) |
| | APC | APC regulator of WNT signaling pathway. (2880 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa) |
| | CTNND1 | Catenin delta 1. (939 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | CTNNBIP1 | Catenin beta interacting protein 1. (81 aa) |
| | OTUD5 | OTU deubiquitinase 5. (566 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa) |
| | PFDN5-2 | Uncharacterized protein. (156 aa) |
| | DKKL1 | Dickkopf like acrosomal protein 1. (233 aa) |
| | UBAC2 | UBA domain containing 2. (349 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (294 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (483 aa) |
| | ISL1 | ISL LIM homeobox 1. (349 aa) |
| | EMD | Emerin. (261 aa) |
| | SCYL2 | SCY1 like pseudokinase 2. (866 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (346 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (471 aa) |
| | APOE | Apolipoprotein E. (326 aa) |
| | DACT3 | Dishevelled binding antagonist of beta catenin 3. (632 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa) |
| | SOX9 | SRY-box transcription factor 9. (525 aa) |
| | FRZB | Frizzled related protein. (325 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (419 aa) |
| | NOTCH1 | Notch receptor 1. (2508 aa) |
| | ENSCHIP00000023383 | RBR-type E3 ubiquitin transferase. (84 aa) |
| | SOX17 | SRY-box transcription factor 17. (410 aa) |
| | PFDN5 | Uncharacterized protein. (154 aa) |
| | LATS2 | Large tumor suppressor kinase 2. (1015 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (831 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa) |
| | AXIN2 | Axin 2. (844 aa) |
| | TMEM170B | Transmembrane protein 170B. (132 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa) |
| | SOX10 | SRY-box transcription factor 10. (469 aa) |
| | TMEM131L | Transmembrane 131 like. (1599 aa) |
| | SOST | Sclerostin. (212 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (774 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (565 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | PTPRU | Protein tyrosine phosphatase receptor type U. (1448 aa) |
| | SHISA3 | Shisa family member 3. (238 aa) |
| | LOC108634926 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (336 aa) |
| | TLE6 | TLE family member 6, subcortical maternal complex member. (575 aa) |
| | GPC3 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (769 aa) |
| | FOXO3 | Forkhead box O3. (672 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (672 aa) |
| | LIMD1 | LIM domains containing 1. (671 aa) |
| | TMEM88 | Transmembrane protein 88. (159 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (499 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (419 aa) |
| | INVS | Inversin. (1017 aa) |
| | AMER2 | APC membrane recruitment protein 2. (634 aa) |
| | TPBG | Trophoblast glycoprotein. (420 aa) |
| | STK4 | Serine/threonine kinase 4. (487 aa) |
| | AMER1 | Uncharacterized protein. (1101 aa) |
| | DAB2IP | DAB2 interacting protein. (1198 aa) |
| | GLI1 | GLI family zinc finger 1. (1105 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (256 aa) |
| | SFRP4 | Secreted frizzled related protein 4. (346 aa) |
| | NPHP4 | Nephrocystin 4. (1431 aa) |
| | RBMS3 | RNA binding motif single stranded interacting protein 3. (437 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | DAB2 | DAB adaptor protein 2. (768 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | BICC1 | BicC family RNA binding protein 1. (972 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1216 aa) |
| | GREM1 | Gremlin. (184 aa) |
| | STK3 | Serine/threonine kinase 3. (495 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (386 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (195 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (349 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | ENSCHIP00000009331 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (327 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (206 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (834 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (243 aa) |
| | BMP2 | TGF_BETA_2 domain-containing protein. (381 aa) |
| | SOX13 | SRY-box transcription factor 13. (592 aa) |
| | TLE5 | TLE family member 5, transcriptional modulator. (197 aa) |
| | FRMD8 | FERM domain containing 8. (463 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (308 aa) |
| | AMFR | Autocrine motility factor receptor. (630 aa) |
| | LOC102176871 | Uncharacterized protein. (921 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | CBY1 | Uncharacterized protein. (127 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (262 aa) |
| | LOC102181663 | Uncharacterized protein. (119 aa) |
| | GLI3 | GLI family zinc finger 3. (1614 aa) |
| | JADE1 | Jade family PHD finger 1. (863 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (333 aa) |
| | LMBR1L | Limb development membrane protein 1 like; Belongs to the LIMR family. (492 aa) |
| | TMEM64 | Transmembrane protein 64. (383 aa) |
| | NPHP3 | TPR_REGION domain-containing protein. (1325 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (465 aa) |
| | TLE7 | TLE family member 7. (438 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa) |
| | ANKRD6 | Ankyrin repeat domain 6. (693 aa) |
| | PARK2 | Ubiquitin-like domain-containing protein. (293 aa) |
| | TNN | Tenascin N. (1384 aa) |
| | CCDC88C | Coiled-coil domain containing 88C. (2021 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2305 aa) |
| | FERMT1 | Fermitin family member 1. (679 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1077 aa) |
