STRINGSTRING
WNT1 WNT1 NPNT NPNT SMAD4 SMAD4 CITED1 CITED1 CAV1 CAV1 SMAD7 SMAD7 KIAA0319 KIAA0319 GDF6 GDF6 PMEPA1 PMEPA1 NREP NREP SOST SOST SMAD2 SMAD2 EMILIN1 EMILIN1 SNX25 SNX25 BMPR2 BMPR2 TMPRSS6 TMPRSS6 FGF9 FGF9 WFIKKN2 WFIKKN2 LATS2 LATS2 SORL1 SORL1 VWC2 VWC2 BMP8A BMP8A ENSCHIP00000023559 ENSCHIP00000023559 BMP4 BMP4 NOTCH1 NOTCH1 FOLR1 FOLR1 MYOCD MYOCD HIPK2 HIPK2 FBN1 FBN1 ABL1 ABL1 STK11 STK11 NUP93 NUP93 ZNF703 ZNF703 HES5 HES5 STRAP STRAP CD109 CD109 DLX6 DLX6 TGFBR1 TGFBR1 INHBE INHBE NOTCH2 NOTCH2 PPM1A PPM1A ZBTB7A ZBTB7A TGFB2 TGFB2 SFRP2 SFRP2 HTRA3 HTRA3 KIAA1324L KIAA1324L SCUBE3 SCUBE3 VWC2L VWC2L GIPC2 GIPC2 MPP5 MPP5 RNF111 RNF111 NKX2-1 NKX2-1 DMRT1 DMRT1 SH2B1 SH2B1 RASL11B RASL11B INHBB INHBB RBPMS2 RBPMS2 NBL1 NBL1 SPART SPART SFRP5 SFRP5 LTBP1 LTBP1 SOX11 SOX11 ENSCHIP00000030069 ENSCHIP00000030069 BMP3 BMP3 TP53 TP53 HSPA5 HSPA5 BMP8B BMP8B UBE2O UBE2O UCMA UCMA CDKN2B CDKN2B INHBA INHBA CDKN2A CDKN2A BMP10 BMP10 IL17RD IL17RD CRB2 CRB2 PPARA PPARA TWSG1 TWSG1 BMP6 BMP6 GDF1 GDF1 ZEB1 ZEB1 PELO PELO KDR KDR TFAP2B TFAP2B NUMA1 NUMA1 EID2 EID2 HOXA13 HOXA13 ENSCHIP00000004051 ENSCHIP00000004051 IL17F IL17F SPRY2 SPRY2 IGSF1 IGSF1 SKIL SKIL NOG NOG SULF1 SULF1 ENG ENG LATS1 LATS1 ENSCHIP00000005279 ENSCHIP00000005279 DAB2 DAB2 RNF165 RNF165 GLG1 GLG1 BMP7 BMP7 CAV3 CAV3 SNW1 SNW1 CRIM1 CRIM1 GDF10 GDF10 AXIN1 AXIN1 HJV HJV BMP5 BMP5 HFE HFE LOC102183990 LOC102183990 GREM1 GREM1 ADAMTSL2 ADAMTSL2 WFIKKN1 WFIKKN1 LINGO3 LINGO3 NEO1 NEO1 SIRT1 SIRT1 TBX20 TBX20 SPRED1 SPRED1 GDF7 GDF7 CHRD CHRD SMURF2 SMURF2 ACVRL1 ACVRL1 VEPH1 VEPH1 GDF15 GDF15 ZNF423 ZNF423 RBPMS RBPMS FLCN FLCN CCN1 CCN1 GDF11 GDF11 SLC2A10 SLC2A10 VASN VASN TGFB3 TGFB3 TOB1 TOB1 BCL9L BCL9L ENSCHIP00000000105 ENSCHIP00000000105 LDLRAD4 LDLRAD4 LOC102183132 LOC102183132 NODAL NODAL BMPR1A BMPR1A CILP2 CILP2 CER1 CER1 FST FST NRROS NRROS TGFBR2 TGFBR2 SKI SKI SKOR2 SKOR2 GDF3 GDF3 FSTL3 FSTL3 KCP KCP TGFB1 TGFB1 TRIM33 TRIM33 ONECUT2 ONECUT2 ING2 ING2 NANOG NANOG SOSTDC1 SOSTDC1 CTDSPL2 CTDSPL2 GDF5 GDF5 CDKN1C CDKN1C SMAD6 SMAD6 CILP CILP FGF10 FGF10 PIN1 PIN1 TGFB1I1 TGFB1I1 BMP2 BMP2 CAV2 CAV2 TNFAIP6 TNFAIP6 C20orf27 C20orf27 LEMD3 LEMD3 FBN2 FBN2 ACVR2A ACVR2A FAM89B FAM89B CSNK2B CSNK2B MEN1 MEN1 ADAM17 ADAM17 SMAD3 SMAD3 PBLD PBLD MSX1 MSX1 DLX1 DLX1 SFRP1 SFRP1 ENSCHIP00000012897 ENSCHIP00000012897 CHRDL2 CHRDL2 BAMBI BAMBI ITGA3 ITGA3 HTRA1 HTRA1 PDPK1 PDPK1 CHST11 CHST11 CDH5 CDH5 TGFBR3 TGFBR3 ASPN ASPN WNT5A WNT5A GIPC1 GIPC1 ZNF451 ZNF451 LRG1 LRG1 FERMT1 FERMT1 LOC102183441 LOC102183441 ILK ILK LY6G5B LY6G5B SKOR1 SKOR1 LEMD2 LEMD2 PRDM16 PRDM16 CREBBP CREBBP INHBC INHBC SDCBP SDCBP THBS1 THBS1 FBXL15 FBXL15 EP300 EP300 SMURF1 SMURF1 HES1 HES1 LOC102178324 LOC102178324 ZC3H3 ZC3H3 GDF2 GDF2 ONECUT1 ONECUT1 BMPER BMPER LOC102170698 LOC102170698 ACVR1B ACVR1B GPC3 GPC3 GIPC3 GIPC3 LRP2 LRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NPNTNephronectin. (606 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (247 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
KIAA0319KIAA0319. (1066 aa)
GDF6Growth differentiation factor 6. (463 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (290 aa)
NREPUncharacterized protein. (67 aa)
SOSTSclerostin. (212 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
EMILIN1Elastin microfibril interfacer 1. (1017 aa)
SNX25Sorting nexin 25. (844 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (816 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (574 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
SORL1Sortilin related receptor 1. (2211 aa)
VWC2Von Willebrand factor C domain containing 2. (326 aa)
BMP8ATGF_BETA_2 domain-containing protein. (405 aa)
ENSCHIP00000023559Uncharacterized protein. (152 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
FOLR1Folate_rec domain-containing protein. (251 aa)
MYOCDMyocardin. (982 aa)
HIPK2Homeodomain interacting protein kinase 2. (1228 aa)
FBN1Fibrillin 1. (2860 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
ZNF703Zinc finger protein 703. (588 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
CD109CD109 molecule. (1446 aa)
DLX6Distal-less homeobox 6. (230 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
INHBEInhibin subunit beta E. (348 aa)
NOTCH2Notch receptor 2. (2471 aa)
PPM1APPM-type phosphatase domain-containing protein. (382 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (602 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
HTRA3HtrA serine peptidase 3. (453 aa)
KIAA1324LKIAA1324 like. (1029 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (936 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
GIPC2GIPC PDZ domain containing family member 2. (313 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
RNF111Ring finger protein 111. (986 aa)
NKX2-1NK2 homeobox 1. (370 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
SH2B1SH2B adaptor protein 1. (775 aa)
RASL11BRAS like family 11 member B. (248 aa)
INHBBInhibin subunit beta B. (408 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (197 aa)
NBL1NBL1, DAN family BMP antagonist. (187 aa)
SPARTSpartin. (668 aa)
SFRP5Secreted frizzled related protein 5. (320 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1491 aa)
SOX11Transcription factor SOX. (444 aa)
ENSCHIP00000030069PDZ domain-containing protein. (123 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (467 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
HSPA5Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family. (655 aa)
BMP8BTGF_BETA_2 domain-containing protein. (405 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1285 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (132 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
INHBAInhibin beta A subunit. (425 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (157 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
IL17RDInterleukin 17 receptor D. (738 aa)
CRB2Crumbs cell polarity complex component 2. (1275 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
GDF1TGF_BETA_2 domain-containing protein. (368 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (386 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
TFAP2BTranscription factor AP-2 beta. (476 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2115 aa)
EID2EP300 interacting inhibitor of differentiation 2. (217 aa)
HOXA13Homeobox A13. (388 aa)
ENSCHIP00000004051Uncharacterized protein. (207 aa)
IL17FUncharacterized protein. (178 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
IGSF1Immunoglobulin superfamily member 1. (1337 aa)
SKILc-SKI_SMAD_bind domain-containing protein. (684 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)
ENGEndoglin. (649 aa)
LATS1Large tumor suppressor kinase 1. (1145 aa)
ENSCHIP00000005279RRM domain-containing protein. (80 aa)
DAB2DAB adaptor protein 2. (768 aa)
RNF165Ring finger protein 165. (347 aa)
GLG1Golgi glycoprotein 1. (1234 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SNW1SNW domain containing 1. (536 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1035 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (478 aa)
AXIN1Axin 1. (867 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (356 aa)
LOC102183990Left-right determination factor. (367 aa)
GREM1Gremlin. (184 aa)
ADAMTSL2ADAMTS like 2. (957 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (550 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (592 aa)
NEO1Neogenin 1. (1472 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
TBX20T-box transcription factor 20. (449 aa)
SPRED1Sprouty related EVH1 domain containing 1. (433 aa)
GDF7Growth differentiation factor 7. (451 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)
SMURF2E3 ubiquitin-protein ligase. (741 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (850 aa)
GDF15Growth differentiation factor 15. (308 aa)
ZNF423Zinc finger protein 423. (1308 aa)
RBPMSRNA binding protein, mRNA processing factor. (197 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
CCN1Cellular communication network factor 1. (382 aa)
GDF11Growth differentiation factor 11. (406 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (536 aa)
VASNVasorin. (672 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
TOB1Transducer of ERBB2, 1. (342 aa)
BCL9LBCL9 like. (1495 aa)
ENSCHIP00000000105c-SKI_SMAD_bind domain-containing protein. (664 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (289 aa)
LOC102183132VWFC domain-containing protein. (193 aa)
NODALNodal growth differentiation factor. (346 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CILP2Cartilage intermediate layer protein 2. (1157 aa)
CER1Cerberus 1, DAN family BMP antagonist. (263 aa)
FSTUncharacterized protein. (344 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
SKISKI proto-oncogene. (729 aa)
SKOR2SKI family transcriptional corepressor 2. (998 aa)
GDF3Growth differentiation factor 3. (364 aa)
FSTL3Follistatin like 3. (274 aa)
KCPKielin cysteine rich BMP regulator. (1662 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
ONECUT2One cut domain family member. (511 aa)
ING2Inhibitor of growth protein. (283 aa)
NANOGHomeobox domain-containing protein. (300 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
GDF5Growth differentiation factor 5. (499 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (254 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
CILPCartilage intermediate layer protein. (1181 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
TGFB1I1Transforming growth factor beta 1 induced transcript 1. (415 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
C20orf27Chromosome 20 open reading frame 27. (174 aa)
LEMD3LEM domain containing 3. (912 aa)
FBN2Fibrillin 2. (2900 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
FAM89BFamily with sequence similarity 89 member B. (192 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (217 aa)
MEN1Menin 1. (609 aa)
ADAM17ADAM metallopeptidase domain 17. (829 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
MSX1Msh homeobox 1. (303 aa)
DLX1Distal-less homeobox 1. (255 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
ENSCHIP00000012897PPM-type phosphatase domain-containing protein. (365 aa)
CHRDL2Chordin like 2. (430 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
HTRA1HtrA serine peptidase 1. (487 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
CHST11Carbohydrate sulfotransferase. (362 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
TGFBR3Transforming growth factor beta receptor 3. (859 aa)
ASPNAsporin. (370 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
ZNF451Zinc finger protein 451. (1025 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (353 aa)
FERMT1Fermitin family member 1. (679 aa)
LOC102183441Left-right determination factor. (367 aa)
ILKIntegrin linked kinase. (452 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (196 aa)
SKOR1SKI family transcriptional corepressor 1. (963 aa)
LEMD2LEM domain containing 2. (495 aa)
PRDM16PR/SET domain 16. (1271 aa)
CREBBPCREB binding protein. (2435 aa)
INHBCInhibin subunit beta C. (352 aa)
SDCBPSyndecan binding protein. (359 aa)
THBS1Thrombospondin 1. (1218 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
EP300E1A binding protein p300. (2411 aa)
SMURF1E3 ubiquitin-protein ligase. (731 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
LOC102178324Uncharacterized protein. (1222 aa)
ZC3H3Zinc finger CCCH-type containing 3. (943 aa)
GDF2Growth differentiation factor 2. (430 aa)
ONECUT1One cut domain family member. (464 aa)
BMPERBMP binding endothelial regulator. (685 aa)
LOC102170698Uncharacterized protein. (512 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
GIPC3GIPC PDZ domain containing family member 3. (318 aa)
LRP2LDL receptor related protein 2. (4649 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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