node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL6 | CTBP1 | ENSCHIP00000032540 | ENSCHIP00000030551 | BCL6 transcription repressor. | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.485 |
BCL6 | IFNG | ENSCHIP00000032540 | ENSCHIP00000016152 | BCL6 transcription repressor. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | 0.741 |
BCL6 | SIRT1 | ENSCHIP00000032540 | ENSCHIP00000007571 | BCL6 transcription repressor. | Deacetylase sirtuin-type domain-containing protein. | 0.691 |
BCL6 | TP53 | ENSCHIP00000032540 | ENSCHIP00000030141 | BCL6 transcription repressor. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.722 |
BRMS1 | ING2 | ENSCHIP00000029987 | ENSCHIP00000009254 | BRMS1 transcriptional repressor and anoikis regulator. | Inhibitor of growth protein. | 0.765 |
CTBP1 | BCL6 | ENSCHIP00000030551 | ENSCHIP00000032540 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | BCL6 transcription repressor. | 0.485 |
CTBP1 | SIRT1 | ENSCHIP00000030551 | ENSCHIP00000007571 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Deacetylase sirtuin-type domain-containing protein. | 0.448 |
CTBP1 | TP53 | ENSCHIP00000030551 | ENSCHIP00000030141 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.417 |
DYRK1A | TP53 | ENSCHIP00000031930 | ENSCHIP00000030141 | Dual specificity tyrosine phosphorylation regulated kinase 1A. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.599 |
IFNG | BCL6 | ENSCHIP00000016152 | ENSCHIP00000032540 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | BCL6 transcription repressor. | 0.741 |
IFNG | SIRT1 | ENSCHIP00000016152 | ENSCHIP00000007571 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | Deacetylase sirtuin-type domain-containing protein. | 0.528 |
IFNG | TGFB1 | ENSCHIP00000016152 | ENSCHIP00000008885 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.786 |
IFNG | TP53 | ENSCHIP00000016152 | ENSCHIP00000030141 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.797 |
ING2 | BRMS1 | ENSCHIP00000009254 | ENSCHIP00000029987 | Inhibitor of growth protein. | BRMS1 transcriptional repressor and anoikis regulator. | 0.765 |
ING2 | TP53 | ENSCHIP00000009254 | ENSCHIP00000030141 | Inhibitor of growth protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.576 |
LRRK2 | PINK1 | ENSCHIP00000024743 | ENSCHIP00000031148 | Leucine rich repeat kinase 2. | PTEN induced kinase 1. | 0.730 |
NDN | TP53 | ENSCHIP00000004605 | ENSCHIP00000030141 | Necdin, MAGE family member. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.614 |
PINK1 | LRRK2 | ENSCHIP00000031148 | ENSCHIP00000024743 | PTEN induced kinase 1. | Leucine rich repeat kinase 2. | 0.730 |
PINK1 | SIRT1 | ENSCHIP00000031148 | ENSCHIP00000007571 | PTEN induced kinase 1. | Deacetylase sirtuin-type domain-containing protein. | 0.666 |
PINK1 | TP53 | ENSCHIP00000031148 | ENSCHIP00000030141 | PTEN induced kinase 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.444 |