STRINGSTRING
BCL6 BCL6 AKAP8L AKAP8L NDN NDN SUV39H1 SUV39H1 SIRT1 SIRT1 NIPBL NIPBL FNTA FNTA TGFB1 TGFB1 ING2 ING2 ENSCHIP00000010160 ENSCHIP00000010160 SMARCA5 SMARCA5 LOC108637664 LOC108637664 IFNG IFNG JDP2 JDP2 PRKD1 PRKD1 RRP8 RRP8 ENSCHIP00000021464 ENSCHIP00000021464 SDR16C5 SDR16C5 SAP30BP SAP30BP ENSCHIP00000023661 ENSCHIP00000023661 LOC102186084 LOC102186084 PRKD2 PRKD2 LRRK2 LRRK2 APLNR APLNR C6orf89 C6orf89 LOC102186976 LOC102186976 BRMS1 BRMS1 SREBF1 SREBF1 ENSCHIP00000030107 ENSCHIP00000030107 TP53 TP53 CTBP1 CTBP1 PINK1 PINK1 ZBTB7B ZBTB7B DYRK1A DYRK1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL6BCL6 transcription repressor. (706 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (642 aa)
NDNNecdin, MAGE family member. (325 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
NIPBLNipped-B protein. (2804 aa)
FNTAUncharacterized protein. (378 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ING2Inhibitor of growth protein. (283 aa)
ENSCHIP00000010160Uncharacterized protein. (252 aa)
SMARCA5Uncharacterized protein. (1052 aa)
LOC108637664Uncharacterized protein. (1041 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
JDP2Jun dimerization protein 2. (163 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (487 aa)
ENSCHIP00000021464Uncharacterized protein. (135 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
SAP30BPSAP30 binding protein. (335 aa)
ENSCHIP00000023661Uncharacterized protein. (344 aa)
LOC102186084Uncharacterized protein. (293 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
C6orf89Chromosome 6 open reading frame 89. (348 aa)
LOC102186976Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (253 aa)
SREBF1Uncharacterized protein. (68 aa)
ENSCHIP00000030107Uncharacterized protein. (363 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
PINK1PTEN induced kinase 1. (587 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (539 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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