(63 nodes) Regulation of membrane permeability network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102183503	AIG1-type G domain-containing protein. (309 aa)
	BAD	BCL2 associated agonist of cell death. (198 aa)
	RHOT1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (704 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (208 aa)
	GIMAP5	AIG1-type G domain-containing protein. (298 aa)
	SLC25A5	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	ATP5IF1	ATP synthase inhibitory factor subunit 1. (109 aa)
	LAPTM4B	Uncharacterized protein. (226 aa)
	ENSCHIP00000003765	AIG1-type G domain-containing protein. (277 aa)
	ENSCHIP00000005577	Uncharacterized protein. (193 aa)
	ENSCHIP00000005639	Uncharacterized protein. (191 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1151 aa)
	JAM3	Junctional adhesion molecule 3. (329 aa)
	BBC3	Uncharacterized protein. (193 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	SLC25A6	Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	HK2	Hexokinase 2. (917 aa)
	LOC108635823	AIG1-type G domain-containing protein. (297 aa)
	NAIF1	Nuclear apoptosis inducing factor 1. (327 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (264 aa)
	BID	Uncharacterized protein. (244 aa)
	TMEM102	Transmembrane protein 102. (513 aa)
	STPG1	Sperm tail PG-rich repeat containing 1. (335 aa)
	ENSCHIP00000013872	Uncharacterized protein. (197 aa)
	ENSCHIP00000013896	Uncharacterized protein. (179 aa)
	THEM4	Thioesterase superfamily member 4. (268 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (785 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	RASIP1	Ras interacting protein 1. (961 aa)
	BNIP3	BCL2 interacting protein 3. (193 aa)
	NOL3	Nucleolar protein 3. (230 aa)
	RHOT2	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (594 aa)
	SLC25A31	Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
	TMEM14A	Transmembrane protein 14A. (99 aa)
	ENSCHIP00000019858	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (288 aa)
	TMIGD1	Transmembrane and immunoglobulin domain containing 1. (261 aa)
	MT3	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
	ENSCHIP00000022485	AIG1-type G domain-containing protein. (295 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (350 aa)
	LOC102178618	AIG1-type G domain-containing protein. (214 aa)
	F11R	F11 receptor. (298 aa)
	SLC35F6	Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (371 aa)
	ENSCHIP00000025165	Uncharacterized protein. (194 aa)
	ENSCHIP00000025214	Uncharacterized protein. (222 aa)
	LOC102183495	Uncharacterized protein. (209 aa)
	LAPTM4A	Lysosomal protein transmembrane 4 alpha. (233 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
	ZNF205	Zinc finger protein 205. (552 aa)
	HEBP2	Heme binding protein 2. (205 aa)
	ACAA2	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	ALKBH7	AlkB homolog 7. (221 aa)
	BNIP3L	Uncharacterized protein. (227 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1115 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	LOC108637894	Uncharacterized protein. (211 aa)
	SLC25A4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF2	TP53	ENSCHIP00000008183	ENSCHIP00000030141	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.516
BAD	BAK1	ENSCHIP00000014347	ENSCHIP00000015729	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.894
BAD	BCL2	ENSCHIP00000014347	ENSCHIP00000015831	BCL2 associated agonist of cell death.	BH4_2 domain-containing protein.	0.999
BAD	BCL2L11	ENSCHIP00000014347	ENSCHIP00000022113	BCL2 associated agonist of cell death.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.897
BAD	BID	ENSCHIP00000014347	ENSCHIP00000012715	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.908
BAD	BOK	ENSCHIP00000014347	ENSCHIP00000032386	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.795
BAD	TP53	ENSCHIP00000014347	ENSCHIP00000030141	BCL2 associated agonist of cell death.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.508
BAK1	BAD	ENSCHIP00000015729	ENSCHIP00000014347	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.894
BAK1	BBC3	ENSCHIP00000015729	ENSCHIP00000006546	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.874
BAK1	BCL2	ENSCHIP00000015729	ENSCHIP00000015831	BCL2 antagonist/killer 1.	BH4_2 domain-containing protein.	0.986
BAK1	BCL2L11	ENSCHIP00000015729	ENSCHIP00000022113	BCL2 antagonist/killer 1.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.957
BAK1	BID	ENSCHIP00000015729	ENSCHIP00000012715	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.999
BAK1	PMAIP1	ENSCHIP00000015729	ENSCHIP00000015262	BCL2 antagonist/killer 1.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.808
BAK1	PPIF	ENSCHIP00000015729	ENSCHIP00000000334	BCL2 antagonist/killer 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.465
BAK1	SLC25A31	ENSCHIP00000015729	ENSCHIP00000018418	BCL2 antagonist/killer 1.	Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.403
BAK1	SLC25A4	ENSCHIP00000015729	ENSCHIP00000032937	BCL2 antagonist/killer 1.	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.403
BAK1	TP53	ENSCHIP00000015729	ENSCHIP00000030141	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.983
BBC3	BAK1	ENSCHIP00000006546	ENSCHIP00000015729	Uncharacterized protein.	BCL2 antagonist/killer 1.	0.874
BBC3	BCL2	ENSCHIP00000006546	ENSCHIP00000015831	Uncharacterized protein.	BH4_2 domain-containing protein.	0.997
BBC3	BCL2L11	ENSCHIP00000006546	ENSCHIP00000022113	Uncharacterized protein.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.960