STRINGSTRING
ENSCHIP00000000047 ENSCHIP00000000047 SHLD2 SHLD2 SMCHD1 SMCHD1 LOC102177756 LOC102177756 ENSCHIP00000001384 ENSCHIP00000001384 POLL POLL LOC108634517 LOC108634517 ENSCHIP00000002654 ENSCHIP00000002654 RNF169 RNF169 RAD50 RAD50 PAXX PAXX RNF8 RNF8 ARPC2 ARPC2 POLK POLK RAD18 RAD18 ZGRF1 ZGRF1 ERCC6 ERCC6 SMC6 SMC6 TP53BP1 TP53BP1 POLH POLH NKX3-1 NKX3-1 TIMELESS TIMELESS NBN NBN LOC102168811 LOC102168811 ATF2 ATF2 ADPRHL2 ADPRHL2 WDR76 WDR76 WDR70 WDR70 REC114 REC114 FAM178B FAM178B ESCO2 ESCO2 SMARCAD1 SMARCAD1 RBBP8 RBBP8 ENSCHIP00000010891 ENSCHIP00000010891 SMARCA5 SMARCA5 RFWD3 RFWD3 NHEJ1 NHEJ1 AUNIP AUNIP SHLD1 SHLD1 DDB1 DDB1 UBQLN4 UBQLN4 TRAIP TRAIP APLF APLF SLF1 SLF1 NABP2 NABP2 ARPC4 ARPC4 WRAP53 WRAP53 ACTR3 ACTR3 XRCC4 XRCC4 PARP3 PARP3 TONSL TONSL PARP9 PARP9 INIP INIP LOC108637664 LOC108637664 SIRT7 SIRT7 UFL1 UFL1 ARPC5 ARPC5 SMC5 SMC5 XPC XPC PARP1 PARP1 VCP VCP PRPF19 PRPF19 CGAS CGAS RPA2 RPA2 MMS22L MMS22L HELQ HELQ RIF1 RIF1 SLF2 SLF2 DDB2 DDB2 MRE11 MRE11 XRCC5 XRCC5 ZBTB7A ZBTB7A LMNA LMNA PHF1 PHF1 RNF168 RNF168 RPA3 RPA3 CUL5 CUL5 PNKP PNKP ARPC3 ARPC3 WAS WAS HUS1 HUS1 PARP2 PARP2 TP53 TP53 OARD1 OARD1 SMARCAL1 SMARCAL1 NABP1 NABP1 ENSCHIP00000031435 ENSCHIP00000031435 INTS3 INTS3 KAT7 KAT7 ENSCHIP00000031547 ENSCHIP00000031547 SIRT6 SIRT6 CBX5 CBX5 RPA1 RPA1 RAD51 RAD51 ACTR3B ACTR3B ENSCHIP00000033297 ENSCHIP00000033297 CNTD1 CNTD1 SAMHD1 SAMHD1 HELB HELB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
SHLD2Shieldin complex subunit 2. (918 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
LOC102177756HTH_48 domain-containing protein. (337 aa)
ENSCHIP00000001384Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (237 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
LOC108634517Uncharacterized protein; Belongs to the actin family. (214 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
RNF169Ring finger protein 169. (708 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
PAXXPAXX non-homologous end joining factor. (201 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
POLKDNA polymerase kappa. (905 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (502 aa)
ZGRF1Uncharacterized protein. (1855 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
SMC6Structural maintenance of chromosomes 6. (1116 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
POLHDNA polymerase eta. (733 aa)
NKX3-1NK3 homeobox 1. (239 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (368 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (626 aa)
WDR70WD repeat domain 70. (652 aa)
REC114REC114 meiotic recombination protein. (252 aa)
FAM178BFamily with sequence similarity 178 member B. (699 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (610 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
ENSCHIP00000010891Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (116 aa)
SMARCA5Uncharacterized protein. (1052 aa)
RFWD3Ring finger and WD repeat domain 3. (791 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
AUNIPAurora kinase A and ninein interacting protein. (357 aa)
SHLD1Shieldin complex subunit 1. (206 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
UBQLN4Ubiquilin 4. (601 aa)
TRAIPTRAF interacting protein. (471 aa)
APLFAprataxin and PNKP like factor. (480 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1056 aa)
NABP2Nucleic acid binding protein 2. (175 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (178 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (405 aa)
XRCC4X-ray repair cross complementing 4. (332 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
TONSLTonsoku like, DNA repair protein. (1371 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
INIPINTS3 and NABP interacting protein. (102 aa)
LOC108637664Uncharacterized protein. (1041 aa)
SIRT7Sirtuin 7. (405 aa)
UFL1UFM1 specific ligase 1. (792 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (877 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
CGASCyclic GMP-AMP synthase. (511 aa)
RPA2Replication protein A2. (270 aa)
MMS22LMMS22 like, DNA repair protein. (1244 aa)
HELQHelicase, POLQ like. (1115 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1167 aa)
DDB2Damage specific DNA binding protein 2. (411 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (602 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
PHF1PHD finger protein 1. (567 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
RPA3Uncharacterized protein. (121 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (194 aa)
WASWASP actin nucleation promoting factor. (536 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
PARP2Poly [ADP-ribose] polymerase. (533 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
OARD1O-acyl-ADP-ribose deacylase 1. (152 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
NABP1Nucleic acid binding protein 1. (205 aa)
ENSCHIP00000031435Uncharacterized protein. (77 aa)
INTS3Integrator complex subunit 3. (1041 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ENSCHIP00000031547HTH_48 domain-containing protein. (342 aa)
SIRT6Sirtuin 6. (335 aa)
CBX5Chromobox 5. (191 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (418 aa)
ENSCHIP00000033297Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (165 aa)
CNTD1Cyclin N-terminal domain containing 1. (339 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (606 aa)
HELBDNA helicase B. (1077 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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