STRINGSTRING
GSK3A GSK3A MCL1 MCL1 CTTN CTTN RIPK1 RIPK1 ENSCHIP00000032485 ENSCHIP00000032485 BOK BOK DDX47 DDX47 INHBA INHBA KITLG KITLG TRADD TRADD DDX3X DDX3X PDIA3 PDIA3 PARP2 PARP2 BCL2L1 BCL2L1 KRT18 KRT18 IL12A IL12A FASLG FASLG YJEFN3 YJEFN3 TGFB2 TGFB2 P2RX7 P2RX7 ENSCHIP00000025610 ENSCHIP00000025610 EYA1 EYA1 ENSCHIP00000025077 ENSCHIP00000025077 CD27 CD27 WWOX WWOX LOC102175959 LOC102175959 SIVA1 SIVA1 GABARAP GABARAP ENSCHIP00000024074 ENSCHIP00000024074 PIK3R1 PIK3R1 PIDD1 PIDD1 ITPRIP ITPRIP DEDD2 DEDD2 SGPP1 SGPP1 TNFRSF1B TNFRSF1B BCL2L11 BCL2L11 SPI1 SPI1 BAG3 BAG3 CASP8 CASP8 KRT8 KRT8 ACVR1B ACVR1B FOXO3 FOXO3 WWOX-2 WWOX-2 CASP8AP2 CASP8AP2 ENSCHIP00000018611 ENSCHIP00000018611 CASP2 CASP2 RB1CC1 RB1CC1 YAP1 YAP1 IFNG IFNG BAX BAX ENSCHIP00000015988 ENSCHIP00000015988 BCL2 BCL2 LOC106503960 LOC106503960 BAK1 BAK1 TLR3 TLR3 LOC108636199 LOC108636199 LOC108635411 LOC108635411 ENSCHIP00000014437 ENSCHIP00000014437 BAD BAD LOC108634246 LOC108634246 PDPK1 PDPK1 GSK3B GSK3B BID BID SFRP1 SFRP1 BCL2A1 BCL2A1 ERBB3 ERBB3 DAXX DAXX SMAD3 SMAD3 DAPK1 DAPK1 FAS FAS DELE1 DELE1 IL7 IL7 FGF10 FGF10 BCL2L2 BCL2L2 TGFB1 TGFB1 IL1A IL1A SORT1 SORT1 NF1 NF1 STK3 STK3 EYA2 EYA2 ITPRIPL2 ITPRIPL2 LOC102183607 LOC102183607 ITGAV ITGAV COL2A1 COL2A1 RNF41 RNF41 PML PML LOC102190074 LOC102190074 SKIL SKIL PRDX2 PRDX2 TNF TNF FADD FADD NGF NGF ENSCHIP00000003468 ENSCHIP00000003468 HIPK1 HIPK1 FGFR3 FGFR3 RAF1 RAF1 DAB2IP DAB2IP CTNNA1 CTNNA1 NDUFA13 NDUFA13 STK4 STK4 MLLT11 MLLT11 TNFSF12 TNFSF12 ENSCHIP00000000255 ENSCHIP00000000255 ENSCHIP00000000207 ENSCHIP00000000207 ENSCHIP00000000105 ENSCHIP00000000105 ENSCHIP00000000025 ENSCHIP00000000025
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
CTTNCortactin. (554 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
ENSCHIP00000032485Uncharacterized protein. (174 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
DDX47DEAD-box helicase 47; Belongs to the DEAD box helicase family. (457 aa)
INHBAInhibin beta A subunit. (425 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
DDX3XUncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
PARP2Poly [ADP-ribose] polymerase. (533 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
YJEFN3YjeF N-terminal domain-containing protein. (253 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
ENSCHIP00000025610TNFR-Cys domain-containing protein. (164 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
ENSCHIP00000025077Uncharacterized protein. (142 aa)
CD27CD27 molecule. (270 aa)
WWOXUncharacterized protein. (153 aa)
LOC102175959Uncharacterized protein. (292 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (176 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
ENSCHIP00000024074BH4_2 domain-containing protein. (240 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIDD1P53-induced death domain protein 1. (913 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (568 aa)
DEDD2Death effector domain containing 2. (326 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
TNFRSF1BTNF receptor superfamily member 1B. (459 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
BAG3BCL2 associated athanogene 3. (576 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
KRT8Keratin 8; Belongs to the intermediate filament family. (484 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
FOXO3Forkhead box O3. (672 aa)
WWOX-2Uncharacterized protein. (208 aa)
CASP8AP2Caspase 8 associated protein 2. (1971 aa)
ENSCHIP00000018611Uncharacterized protein. (183 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (456 aa)
RB1CC1RB1 inducible coiled-coil 1. (1589 aa)
YAP1Yes associated protein 1. (503 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ENSCHIP00000015988Uncharacterized protein. (157 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
LOC106503960TNFR-Cys domain-containing protein. (203 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
LOC108636199Daxx domain-containing protein. (716 aa)
LOC108635411Uncharacterized protein. (223 aa)
ENSCHIP00000014437Uncharacterized protein. (206 aa)
BADBCL2 associated agonist of cell death. (198 aa)
LOC108634246Uncharacterized protein. (215 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BIDUncharacterized protein. (244 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
BCL2A1BCL2 related protein A1. (175 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1344 aa)
DAXXDaxx domain-containing protein. (737 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DAPK1Death associated protein kinase 1. (1440 aa)
FASUncharacterized protein. (297 aa)
DELE1DAP3 binding cell death enhancer 1. (520 aa)
IL7Interleukin 7. (181 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
BCL2L2BCL2 like 2. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
SORT1Sortilin. (832 aa)
NF1Neurofibromin 1. (2848 aa)
STK3Serine/threonine kinase 3. (495 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
ITPRIPL2ITPRIP like 2. (532 aa)
LOC102183607BH4_2 domain-containing protein. (232 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
COL2A1Collagen type II alpha 1 chain. (1259 aa)
RNF41Ring finger protein 41. (317 aa)
PMLPromyelocytic leukemia. (868 aa)
LOC102190074IF rod domain-containing protein; Belongs to the intermediate filament family. (411 aa)
SKILc-SKI_SMAD_bind domain-containing protein. (684 aa)
PRDX2Thioredoxin domain-containing protein. (198 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
ENSCHIP00000003468DED domain-containing protein. (350 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
CTNNA1Catenin alpha 1. (1018 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
STK4Serine/threonine kinase 4. (487 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (90 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (243 aa)
ENSCHIP00000000255Uncharacterized protein. (164 aa)
ENSCHIP00000000207TNFR-Cys domain-containing protein. (136 aa)
ENSCHIP00000000105c-SKI_SMAD_bind domain-containing protein. (664 aa)
ENSCHIP00000000025Uncharacterized protein. (552 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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