18 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	IL17F	Uncharacterized protein. (178 aa)
	IL17D	Interleukin 17D. (193 aa)
	IL17RA	Interleukin 17 receptor A. (786 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (705 aa)
	ANKRD42	Ankyrin repeat domain 42. (572 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	CD6	CD6 molecule. (672 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	GPSM3	G protein signaling modulator 3. (162 aa)
	IL17A	Interleukin-17A. (153 aa)
	PLA2G3	Phospholipase A2 group III. (509 aa)
	NOD2	Uncharacterized protein. (982 aa)
	IL17B	Interleukin 17B. (176 aa)
	CARD9	Caspase recruitment domain family member 9. (519 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD9	CLEC7A	ENSCHIP00000011739	ENSCHIP00000005201	Caspase recruitment domain family member 9.	C-type lectin domain containing 7A.	0.665
CARD9	IL17A	ENSCHIP00000011739	ENSCHIP00000025484	Caspase recruitment domain family member 9.	Interleukin-17A.	0.474
CARD9	IL17F	ENSCHIP00000011739	ENSCHIP00000004124	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.404
CARD9	IL17RA	ENSCHIP00000011739	ENSCHIP00000013103	Caspase recruitment domain family member 9.	Interleukin 17 receptor A.	0.437
CARD9	MYD88	ENSCHIP00000011739	ENSCHIP00000018063	Caspase recruitment domain family member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.717
CARD9	NOD2	ENSCHIP00000011739	ENSCHIP00000029729	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.836
CARD9	TLR4	ENSCHIP00000011739	ENSCHIP00000019512	Caspase recruitment domain family member 9.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.661
CARD9	TNF	ENSCHIP00000011739	ENSCHIP00000004561	Caspase recruitment domain family member 9.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.515
CLEC7A	CARD9	ENSCHIP00000005201	ENSCHIP00000011739	C-type lectin domain containing 7A.	Caspase recruitment domain family member 9.	0.665
CLEC7A	IL17A	ENSCHIP00000005201	ENSCHIP00000025484	C-type lectin domain containing 7A.	Interleukin-17A.	0.453
CLEC7A	MYD88	ENSCHIP00000005201	ENSCHIP00000018063	C-type lectin domain containing 7A.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.557
CLEC7A	NOD2	ENSCHIP00000005201	ENSCHIP00000029729	C-type lectin domain containing 7A.	Uncharacterized protein.	0.555
CLEC7A	TLR4	ENSCHIP00000005201	ENSCHIP00000019512	C-type lectin domain containing 7A.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.658
CLEC7A	TNF	ENSCHIP00000005201	ENSCHIP00000004561	C-type lectin domain containing 7A.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.628
HIF1A	IL17A	ENSCHIP00000014770	ENSCHIP00000025484	Uncharacterized protein.	Interleukin-17A.	0.468
HIF1A	STAT3	ENSCHIP00000014770	ENSCHIP00000022282	Uncharacterized protein.	Signal transducer and activator of transcription.	0.933
HIF1A	TLR4	ENSCHIP00000014770	ENSCHIP00000019512	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.591
HIF1A	TNF	ENSCHIP00000014770	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.670
IL17A	CARD9	ENSCHIP00000025484	ENSCHIP00000011739	Interleukin-17A.	Caspase recruitment domain family member 9.	0.474
IL17A	CLEC7A	ENSCHIP00000025484	ENSCHIP00000005201	Interleukin-17A.	C-type lectin domain containing 7A.	0.453