STRINGSTRING
DLX5 DLX5 JUN JUN CREB3 CREB3 SMAD1 SMAD1 ATF2 ATF2 BMP2 BMP2 SMAD5 SMAD5 ATF4 ATF4 RELA RELA HIF1A HIF1A RUNX2 RUNX2 LOC102170474 LOC102170474 CHD6 CHD6 EP300 EP300 MT3 MT3 NOTCH1 NOTCH1 RBPJ RBPJ CARF CARF XBP1 XBP1 SESN2 SESN2 TP53 TP53 NFE2L2 NFE2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX5Distal-less homeobox 5. (289 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
CREB3cAMP responsive element binding protein 3. (368 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ATF4Activating transcription factor 4. (352 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
HIF1AUncharacterized protein. (823 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
LOC102170474Uncharacterized protein. (238 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2720 aa)
EP300E1A binding protein p300. (2411 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
NOTCH1Notch receptor 1. (2508 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (513 aa)
CARFCalcium responsive transcription factor. (703 aa)
XBP1BZIP domain-containing protein. (261 aa)
SESN2Sestrin 2. (471 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (616 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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