92 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PADI3	Peptidyl arginine deiminase 3. (664 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (523 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
	LOC102179594	Beta_elim_lyase domain-containing protein. (400 aa)
	DDAH2	Dimethylarginine dimethylaminohydrolase 2. (285 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
	HGD	Homogentisate 1,2-dioxygenase. (445 aa)
	LOC108636344	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (430 aa)
	GCSH	Glycine cleavage system protein H. (173 aa)
	LOC102174841	Epimerase domain-containing protein. (388 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa)
	C10orf62	Chromosome 10 open reading frame 62. (225 aa)
	NOS1	Nitric oxide synthase 1. (1468 aa)
	IVD	Isovaleryl-CoA dehydrogenase. (426 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (407 aa)
	ENSCHIP00000030302	NAD_binding_11 domain-containing protein. (291 aa)
	AADAT	Aminotran_1_2 domain-containing protein. (425 aa)
	ASRGL1	Asparaginase and isoaspartyl peptidase 1. (309 aa)
	ACADSB	Acyl-CoA dehydrogenase short/branched chain. (434 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (285 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	GSTZ1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (210 aa)
	HIBCH	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
	ALDH8A1	Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
	MCCC2	Methylcrotonoyl-CoA carboxylase 2. (563 aa)
	NOS2	Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1154 aa)
	AGXT	Serine--pyruvate aminotransferase. (414 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
	ARG1	Arginase. (322 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
	LOC102182692	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (601 aa)
	SDS	Serine dehydratase. (326 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
	CDO1	Cysteine dioxygenase. (200 aa)
	GAD2	Glutamate decarboxylase 2. (585 aa)
	LOC102183203	Amine oxidase. (517 aa)
	THNSL2	Threonine synthase like 2. (484 aa)
	KYAT3	Kynurenine aminotransferase 3. (476 aa)
	IDO1	Uncharacterized protein. (410 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (697 aa)
	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (447 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
	PRODH2	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (461 aa)
	PAH	Phenylalanine hydroxylase. (466 aa)
	ADHFE1	Fe-ADH domain-containing protein. (443 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (340 aa)
	AMT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
	HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	ARG2	Arginase. (354 aa)
	SARDH	Sarcosine dehydrogenase. (929 aa)
	GPT	Glutamic--pyruvic transaminase. (496 aa)
	ENSCHIP00000016545	Lipoyl-binding domain-containing protein. (161 aa)
	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (576 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (468 aa)
	SCLY	Selenocysteine lyase. (437 aa)
	OAT	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	IL4I1	Interleukin 4 induced 1. (582 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	FAH	Fumarylacetoacetase. (419 aa)
	DAO	D-amino acid oxidase. (347 aa)
	SDSL	Serine dehydratase like. (329 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (535 aa)
	ENSCHIP00000008764	Uncharacterized protein. (151 aa)
	PIPOX	Pipecolic acid and sarcosine oxidase. (392 aa)
	ACAD8	Acyl-CoA dehydrogenase family member 8. (415 aa)
	HIBADH	Uncharacterized protein. (336 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (586 aa)
	ENSCHIP00000006971	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (152 aa)
	GCAT	Glycine C-acetyltransferase. (433 aa)
	QDPR	Quinoid dihydropteridine reductase. (242 aa)
	GLS2	Glutaminase 2. (605 aa)
	LOC108634030	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
	AASS	Aminoadipate-semialdehyde synthase. (933 aa)
	MAT1A	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
	BLMH	Bleomycin hydrolase; Belongs to the peptidase C1 family. (469 aa)
	GLS	Glutaminase. (673 aa)
	ENSCHIP00000004162	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (515 aa)
	BCAT2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
	ENSCHIP00000003787	Uncharacterized protein. (164 aa)
	OTC	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (277 aa)
	ENSCHIP00000003272	Uncharacterized protein. (336 aa)
	HPD	4-hydroxyphenylpyruvate dioxygenase. (389 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	ENSCHIP00000001411	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
	DDO	D-aspartate oxidase. (341 aa)
	TDO2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
	GLUD1	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAT	AFMID	ENSCHIP00000030168	ENSCHIP00000032933	Aminotran_1_2 domain-containing protein.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.944
AADAT	BCAT2	ENSCHIP00000030168	ENSCHIP00000003910	Aminotran_1_2 domain-containing protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.725
AADAT	HAAO	ENSCHIP00000030168	ENSCHIP00000012374	Aminotran_1_2 domain-containing protein.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	0.731
AADAT	HPD	ENSCHIP00000030168	ENSCHIP00000003214	Aminotran_1_2 domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.406
AADAT	KMO	ENSCHIP00000030168	ENSCHIP00000019044	Aminotran_1_2 domain-containing protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.974
AADAT	KYAT3	ENSCHIP00000030168	ENSCHIP00000021831	Aminotran_1_2 domain-containing protein.	Kynurenine aminotransferase 3.	0.938
AADAT	KYNU	ENSCHIP00000030168	ENSCHIP00000031339	Aminotran_1_2 domain-containing protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.947
AADAT	QDPR	ENSCHIP00000030168	ENSCHIP00000006722	Aminotran_1_2 domain-containing protein.	Quinoid dihydropteridine reductase.	0.679
AADAT	TDO2	ENSCHIP00000030168	ENSCHIP00000000917	Aminotran_1_2 domain-containing protein.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.425
AADAT	THNSL2	ENSCHIP00000030168	ENSCHIP00000022285	Aminotran_1_2 domain-containing protein.	Threonine synthase like 2.	0.680
AASS	AFMID	ENSCHIP00000005660	ENSCHIP00000032933	Aminoadipate-semialdehyde synthase.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.566
AASS	AGXT	ENSCHIP00000005660	ENSCHIP00000025932	Aminoadipate-semialdehyde synthase.	Serine--pyruvate aminotransferase.	0.637
AASS	AMT	ENSCHIP00000005660	ENSCHIP00000017914	Aminoadipate-semialdehyde synthase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.640
AASS	DAO	ENSCHIP00000005660	ENSCHIP00000010179	Aminoadipate-semialdehyde synthase.	D-amino acid oxidase.	0.466
AASS	GCAT	ENSCHIP00000005660	ENSCHIP00000006770	Aminoadipate-semialdehyde synthase.	Glycine C-acetyltransferase.	0.456
AASS	GLDC	ENSCHIP00000005660	ENSCHIP00000025237	Aminoadipate-semialdehyde synthase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.502
AASS	GLS2	ENSCHIP00000005660	ENSCHIP00000006059	Aminoadipate-semialdehyde synthase.	Glutaminase 2.	0.583
AASS	GPT2	ENSCHIP00000005660	ENSCHIP00000033599	Aminoadipate-semialdehyde synthase.	Glutamic--pyruvic transaminase 2.	0.493
AASS	HGD	ENSCHIP00000005660	ENSCHIP00000032682	Aminoadipate-semialdehyde synthase.	Homogentisate 1,2-dioxygenase.	0.721
AASS	HMGCL	ENSCHIP00000005660	ENSCHIP00000033396	Aminoadipate-semialdehyde synthase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.439