13 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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protein homology

Your Input:
	EPHA4	EPH receptor A4. (986 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (701 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	SLC2A13	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (648 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (205 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (675 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	SP1	Uncharacterized protein. (786 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (571 aa)
	LRRTM3	Leucine rich repeat transmembrane neuronal 3. (581 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	TNF	ENSCHIP00000003297	ENSCHIP00000004561	ATP binding cassette subfamily G member 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.416
CASP3	IFNG	ENSCHIP00000011490	ENSCHIP00000016152	Caspase 3; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.797
CASP3	RELA	ENSCHIP00000011490	ENSCHIP00000013897	Caspase 3; Belongs to the peptidase C14A family.	RELA proto-oncogene, NF-kB subunit.	0.576
CASP3	ROCK2	ENSCHIP00000011490	ENSCHIP00000010884	Caspase 3; Belongs to the peptidase C14A family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.623
CASP3	TNF	ENSCHIP00000011490	ENSCHIP00000004561	Caspase 3; Belongs to the peptidase C14A family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.896
EFNA1	EPHA4	ENSCHIP00000002304	ENSCHIP00000030146	Ephrin A1; Belongs to the ephrin family.	EPH receptor A4.	0.998
EPHA4	EFNA1	ENSCHIP00000030146	ENSCHIP00000002304	EPH receptor A4.	Ephrin A1; Belongs to the ephrin family.	0.998
IFNG	CASP3	ENSCHIP00000016152	ENSCHIP00000011490	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Caspase 3; Belongs to the peptidase C14A family.	0.797
IFNG	RELA	ENSCHIP00000016152	ENSCHIP00000013897	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	RELA proto-oncogene, NF-kB subunit.	0.533
IFNG	TNF	ENSCHIP00000016152	ENSCHIP00000004561	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.973
RELA	CASP3	ENSCHIP00000013897	ENSCHIP00000011490	RELA proto-oncogene, NF-kB subunit.	Caspase 3; Belongs to the peptidase C14A family.	0.576
RELA	IFNG	ENSCHIP00000013897	ENSCHIP00000016152	RELA proto-oncogene, NF-kB subunit.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.533
RELA	ROCK2	ENSCHIP00000013897	ENSCHIP00000010884	RELA proto-oncogene, NF-kB subunit.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.919
RELA	SP1	ENSCHIP00000013897	ENSCHIP00000010095	RELA proto-oncogene, NF-kB subunit.	Uncharacterized protein.	0.780
RELA	TNF	ENSCHIP00000013897	ENSCHIP00000004561	RELA proto-oncogene, NF-kB subunit.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.863
ROCK2	CASP3	ENSCHIP00000010884	ENSCHIP00000011490	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Caspase 3; Belongs to the peptidase C14A family.	0.623
ROCK2	RELA	ENSCHIP00000010884	ENSCHIP00000013897	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	RELA proto-oncogene, NF-kB subunit.	0.919
ROCK2	TNF	ENSCHIP00000010884	ENSCHIP00000004561	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.403
SP1	RELA	ENSCHIP00000010095	ENSCHIP00000013897	Uncharacterized protein.	RELA proto-oncogene, NF-kB subunit.	0.780
SP1	TNF	ENSCHIP00000010095	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.454