STRINGSTRING
PPARGC1B PPARGC1B NKAP NKAP PCID2 PCID2 ZMIZ1 ZMIZ1 LOC102183503 LOC102183503 GIMAP5 GIMAP5 SOCS1 SOCS1 SOCS5 SOCS5 POU4F1 POU4F1 PCK1 PCK1 TNFSF9 TNFSF9 RB1 RB1 VSIR VSIR IL2RG IL2RG RHOH RHOH ENSCHIP00000003765 ENSCHIP00000003765 TREM2 TREM2 SOX12 SOX12 FADD FADD ZBTB16 ZBTB16 TNF TNF HSF1 HSF1 NCKAP1L NCKAP1L GPR68 GPR68 MYB MYB RASGRP1 RASGRP1 CD4 CD4 IL36B IL36B WNT10B WNT10B IL23A IL23A PRKCZ PRKCZ MMP14 MMP14 TGFBR2 TGFBR2 TGFB1 TGFB1 EVI2B EVI2B SYK SYK ZAP70 ZAP70 POU4F2 POU4F2 IL20 IL20 SOX13 SOX13 LOC108635823 LOC108635823 IL7 IL7 RAG1 RAG1 SLC9B2 SLC9B2 ENSCHIP00000011371 ENSCHIP00000011371 AGER AGER RHOA RHOA CD74 CD74 LIF LIF IL4I1 IL4I1 HLX HLX FOXP3 FOXP3 RARA RARA TNFSF11 TNFSF11 PPP2R3C PPP2R3C GLI3 GLI3 BAD BAD KAT5 KAT5 TMEM64 TMEM64 GAS6 GAS6 TRAF6 TRAF6 ITPKB ITPKB SART1 SART1 IFNG IFNG IHH IHH MALT1 MALT1 LOC102170474 LOC102170474 RUNX1 RUNX1 AMBRA1 AMBRA1 KLF10 KLF10 IL12B IL12B FES FES CD83 CD83 VNN1 VNN1 FOXO3 FOXO3 CCL19 CCL19 RIPK2 RIPK2 INPP5D INPP5D AP3B1 AP3B1 CASP8 CASP8 IL4 IL4 ADAM8 ADAM8 HAX1 HAX1 ZBTB1 ZBTB1 IL34 IL34 AXL AXL DUSP10 DUSP10 ENSCHIP00000022485 ENSCHIP00000022485 SASH3 SASH3 OCSTAMP OCSTAMP CBFB CBFB IL7R IL7R LOC102183203 LOC102183203 ANXA1 ANXA1 IL18 IL18 LOC102178618 LOC102178618 NEDD9 NEDD9 DCSTAMP DCSTAMP TRIB1 TRIB1 CD27 CD27 STAT5B STAT5B STAT5A STAT5A IL17A IL17A PTPRC PTPRC NOTCH2 NOTCH2 EGR3 EGR3 ZFP36L1 ZFP36L1 IL12A IL12A SHH SHH XBP1 XBP1 CTNNBIP1 CTNNBIP1 PRKCA PRKCA IL15 IL15 PLA2G3 PLA2G3 TOX TOX IL2 IL2 PIK3R6 PIK3R6 GATA3 GATA3 CD101 CD101 KITLG KITLG LEF1 LEF1 SHB SHB FOS FOS ZBTB7B ZBTB7B IL1RL2 IL1RL2 ENSCHIP00000031987 ENSCHIP00000031987 TESC TESC NFKBIZ NFKBIZ BCL6 BCL6 HCLS1 HCLS1 RIPK1 RIPK1 PPP3CA PPP3CA ADA ADA CSF1 CSF1 CREB1 CREB1 ZBTB46 ZBTB46
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGC1BPPARG coactivator 1 beta. (1021 aa)
NKAPNFKB activating protein. (370 aa)
PCID2PCI domain containing 2. (393 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1072 aa)
LOC102183503AIG1-type G domain-containing protein. (309 aa)
GIMAP5AIG1-type G domain-containing protein. (298 aa)
SOCS1Suppressor of cytokine signaling 1. (219 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
POU4F1POU domain protein. (421 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
TNFSF9TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
RB1RB transcriptional corepressor 1. (931 aa)
VSIRV-set immunoregulatory receptor. (312 aa)
IL2RGFibronectin type-III domain-containing protein. (378 aa)
RHOHRas homolog family member H. (191 aa)
ENSCHIP00000003765AIG1-type G domain-containing protein. (277 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
SOX12Transcription factor SOX. (314 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
ZBTB16Uncharacterized protein. (673 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
HSF1HSF_DOMAIN domain-containing protein. (537 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (371 aa)
MYBMYB proto-oncogene, transcription factor. (640 aa)
RASGRP1RAS guanyl releasing protein 1. (773 aa)
CD4CD4 molecule. (455 aa)
IL36BInterleukin-1. (158 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
MMP14ZnMc domain-containing protein. (584 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EVI2BEcotropic viral integration site 2B. (456 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
ZAP70Tyrosine-protein kinase. (622 aa)
POU4F2POU domain protein. (408 aa)
IL20Interleukin 20. (175 aa)
SOX13SRY-box transcription factor 13. (592 aa)
LOC108635823AIG1-type G domain-containing protein. (297 aa)
IL7Interleukin 7. (181 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
SLC9B2Solute carrier family 9 member B2. (535 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
RHOARas-like protein family member A. (193 aa)
CD74CD74 molecule. (261 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
IL4I1Interleukin 4 induced 1. (582 aa)
HLXH2.0 like homeobox. (488 aa)
FOXP3Forkhead box P3. (463 aa)
RARARetinoic acid receptor alpha. (462 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GLI3GLI family zinc finger 3. (1614 aa)
BADBCL2 associated agonist of cell death. (198 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
TMEM64Transmembrane protein 64. (383 aa)
GAS6Growth arrest specific 6. (671 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (942 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (796 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MALT1MALT1 paracaspase. (830 aa)
LOC102170474Uncharacterized protein. (238 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1300 aa)
KLF10Kruppel like factor 10. (482 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (804 aa)
CD83CD83 molecule. (199 aa)
VNN1Vanin 1. (529 aa)
FOXO3Forkhead box O3. (672 aa)
CCL19C-C motif chemokine. (102 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1202 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
ADAM8ADAM metallopeptidase domain 8. (827 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
IL34Interleukin 34. (233 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ENSCHIP00000022485AIG1-type G domain-containing protein. (295 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (513 aa)
CBFBCore-binding factor subunit beta. (187 aa)
IL7RInterleukin 7 receptor. (459 aa)
LOC102183203Amine oxidase. (517 aa)
ANXA1Annexin. (346 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LOC102178618AIG1-type G domain-containing protein. (214 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (510 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
CD27CD27 molecule. (270 aa)
STAT5BSignal transducer and activator of transcription. (808 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
IL17AInterleukin-17A. (153 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
NOTCH2Notch receptor 2. (2471 aa)
EGR3Early growth response 3. (387 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
XBP1BZIP domain-containing protein. (261 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
PRKCAUncharacterized protein. (605 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
TOXThymocyte selection associated high mobility group box. (527 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (762 aa)
GATA3GATA binding protein 3. (467 aa)
CD101CD101 molecule. (1020 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
LEF1HMG box domain-containing protein. (430 aa)
SHBSH2 domain-containing protein. (507 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (539 aa)
IL1RL2Interleukin 1 receptor like 2. (552 aa)
ENSCHIP00000031987Non-specific serine/threonine protein kinase. (199 aa)
TESCTescalcin. (214 aa)
NFKBIZMolecule possessing ankyrin-repeats induced by lipopolysaccharide. (719 aa)
BCL6BCL6 transcription repressor. (706 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (471 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
ADAAdenosine deaminase. (400 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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