STRINGSTRING
ATRX ATRX SGO1 SGO1 MEI1 MEI1 C7H19orf57 C7H19orf57 LIF LIF CCNB1IP1 CCNB1IP1 ENSCHIP00000013851 ENSCHIP00000013851 FANCM FANCM RAD51C RAD51C ESPL1 ESPL1 RAD1 RAD1 CDC25B CDC25B DDX4 DDX4 NCAPD2 NCAPD2 ACTR3 ACTR3 CENPC CENPC BRIP1 BRIP1 BUB1B BUB1B WNT5A WNT5A EME1 EME1 ENSCHIP00000015645 ENSCHIP00000015645 ROCK1 ROCK1 CENPS CENPS MEI4 MEI4 PSMC3IP PSMC3IP ATM ATM SIRT7 SIRT7 MND1 MND1 M1AP M1AP NDC1 NDC1 OVOL1 OVOL1 CYP26B1 CYP26B1 SLX4 SLX4 SEPTIN1 SEPTIN1 ENSCHIP00000018002 ENSCHIP00000018002 UBE2B UBE2B SLC25A31 SLC25A31 TUBG2 TUBG2 ZSCAN21 ZSCAN21 SYCP2L SYCP2L ENSCHIP00000019703 ENSCHIP00000019703 WEE2 WEE2 SMC4 SMC4 ANKLE1 ANKLE1 NSUN2 NSUN2 SPIRE2 SPIRE2 ASZ1 ASZ1 RAD51D RAD51D MYH9 MYH9 EDNRA EDNRA MSH5 MSH5 RNF212B RNF212B ERCC1 ERCC1 HORMAD2 HORMAD2 TERB1 TERB1 TEX14 TEX14 DNMT3L DNMT3L MSH4 MSH4 TESMIN TESMIN FANCD2 FANCD2 AGO4 AGO4 FBXO5 FBXO5 MEIKIN MEIKIN RAD51 RAD51 ACTR3B ACTR3B CCDC155 CCDC155 SPATA22 SPATA22 CNTD1 CNTD1 PTTG1 PTTG1 SYCP1 SYCP1 RAD54L RAD54L DMRTC2 DMRTC2 REC8 REC8 BCL2L11 BCL2L11 FOXJ2 FOXJ2 NCAPD3 NCAPD3 TOP2B TOP2B CHFR CHFR ANKRD31 ANKRD31 SYCE3 SYCE3 BRCA2 BRCA2 MRE11 MRE11 NUF2 NUF2 FOXJ3 FOXJ3 RAD21L1 RAD21L1 CKS2 CKS2 TRIP13 TRIP13 STAG3 STAG3 ERCC4 ERCC4 CCNE2 CCNE2 PLK1 PLK1 SHCBP1L SHCBP1L SYCE2 SYCE2 INCENP INCENP TUBG1 TUBG1 SPDYA SPDYA MUS81 MUS81 SPO11 SPO11 ZCWPW1 ZCWPW1 HUS1 HUS1 DMRT1 DMRT1 AURKA AURKA CCNE1 CCNE1 DMC1 DMC1 TDRKH TDRKH MAEL MAEL SGO2 SGO2 SYCP2 SYCP2 MEIOB MEIOB SUN1 SUN1 EHMT2 EHMT2 BIRC5 BIRC5 RMI1 RMI1 TERB2 TERB2 TOP2A TOP2A WASHC5 WASHC5 ING2 ING2 BUB1 BUB1 EDN1 EDN1 MASTL MASTL TERF1 TERF1 MOS MOS TEX12 TEX12 SPIRE1 SPIRE1 TDRD9 TDRD9 ENSCHIP00000007999 ENSCHIP00000007999 MEIOC MEIOC HORMAD1 HORMAD1 HSPA2 HSPA2 UBR2 UBR2 LOC102187271 LOC102187271 TTK TTK NCAPH2 NCAPH2 MLH3 MLH3 CCDC36 CCDC36 BAG6 BAG6 MARF1 MARF1 C1orf146 C1orf146 FSBP FSBP ENSCHIP00000003676 ENSCHIP00000003676 RAD50 RAD50 PSMD13 PSMD13 FIGNL1 FIGNL1 ENSCHIP00000002436 ENSCHIP00000002436 HSF2BP HSF2BP SMC2 SMC2 LOC108634517 LOC108634517 FANCA FANCA RPL10L RPL10L KIF18A KIF18A PGRMC1 PGRMC1 SYCE1 SYCE1 LOC102176379 LOC102176379
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATRXATRX chromatin remodeler. (2105 aa)
SGO1Shugoshin 1. (577 aa)
MEI1Meiotic double-stranded break formation protein 1. (1272 aa)
C7H19orf57Uncharacterized protein. (481 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CCNB1IP1Cyclin B1 interacting protein 1. (277 aa)
ENSCHIP00000013851Uncharacterized protein. (113 aa)
FANCMFA complementation group M. (2043 aa)
RAD51CRAD51 paralog C. (371 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2101 aa)
RAD1Uncharacterized protein. (279 aa)
CDC25BRhodanese domain-containing protein. (564 aa)
DDX4DEAD-box helicase 4; Belongs to the DEAD box helicase family. (729 aa)
NCAPD2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1396 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (405 aa)
CENPCCentromere protein C. (953 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
BUB1BUncharacterized protein. (1062 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
EME1Essential meiotic structure-specific endonuclease 1. (580 aa)
ENSCHIP00000015645Uncharacterized protein. (143 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CENPSCentromere protein S. (131 aa)
MEI4Meiotic double-stranded break formation protein 4. (388 aa)
PSMC3IPPSMC3 interacting protein. (217 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
SIRT7Sirtuin 7. (405 aa)
MND1Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (203 aa)
M1APMeiosis 1 associated protein. (534 aa)
NDC1NDC1 transmembrane nucleoporin. (823 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
SEPTIN1Septin 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (373 aa)
ENSCHIP00000018002Uncharacterized protein. (172 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
TUBG2Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
ZSCAN21Zinc finger and SCAN domain containing 21. (472 aa)
SYCP2LSynaptonemal complex protein 2 like. (856 aa)
ENSCHIP00000019703Helicase ATP-binding domain-containing protein. (459 aa)
WEE2Wee1-like protein kinase. (566 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (487 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (842 aa)
SPIRE2Spire type actin nucleation factor 2. (729 aa)
ASZ1Ankyrin repeat, SAM and basic leucine zipper domain containing 1. (493 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (821 aa)
RNF212BRing finger protein 212B. (300 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
HORMAD2HORMA domain containing 2. (306 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (728 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1479 aa)
DNMT3LPHD-type domain-containing protein. (390 aa)
MSH4MutS homolog 4. (930 aa)
TESMINTestis expressed metallothionein like protein. (548 aa)
FANCD2FA complementation group D2. (1423 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (875 aa)
FBXO5F-box protein 5. (448 aa)
MEIKINMeiotic kinetochore factor. (316 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (418 aa)
CCDC155Coiled-coil domain containing 155. (505 aa)
SPATA22Spermatogenesis associated 22. (364 aa)
CNTD1Cyclin N-terminal domain containing 1. (339 aa)
PTTG1Uncharacterized protein. (202 aa)
SYCP1Synaptonemal complex protein 1. (918 aa)
RAD54LRAD54 like. (749 aa)
DMRTC2DMRT like family C2. (370 aa)
REC8REC8 meiotic recombination protein. (564 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
FOXJ2Forkhead box J2. (561 aa)
NCAPD3Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1480 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1609 aa)
CHFRCheckpoint with forkhead and ring finger domains. (662 aa)
ANKRD31ANK_REP_REGION domain-containing protein. (661 aa)
SYCE3Synaptonemal complex central element protein 3. (89 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (465 aa)
FOXJ3Forkhead box J3. (628 aa)
RAD21L1RAD21 cohesin complex component like 1. (554 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
STAG3Stromal antigen 3. (1240 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
SHCBP1LSHC binding and spindle associated 1 like. (663 aa)
SYCE2Synaptonemal complex central element protein 2. (138 aa)
INCENPInner centromere protein. (873 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (312 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (645 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
TDRKHTudor and KH domain containing. (575 aa)
MAELMaelstrom spermatogenic transposon silencer. (434 aa)
SGO2Shugoshin 2. (1383 aa)
SYCP2Synaptonemal complex protein 2. (1456 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
SUN1Sad1 and UNC84 domain containing 1. (889 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1268 aa)
BIRC5Uncharacterized protein. (142 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
TERB2Telomere repeat binding bouquet formation protein 2. (221 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
WASHC5WASH complex subunit 5. (1159 aa)
ING2Inhibitor of growth protein. (283 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1090 aa)
EDN1Endothelin 1. (202 aa)
MASTLMicrotubule associated serine/threonine kinase like. (881 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (340 aa)
TEX12Testis expressed 12. (123 aa)
SPIRE1Spire type actin nucleation factor 1. (781 aa)
TDRD9Tudor domain containing 9. (1375 aa)
ENSCHIP00000007999Uncharacterized protein. (233 aa)
MEIOCMeiosis specific with coiled-coil domain. (960 aa)
HORMAD1HORMA domain containing 1. (377 aa)
HSPA2Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] (636 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1756 aa)
LOC102187271Rhodanese domain-containing protein. (506 aa)
TTKTTK protein kinase. (852 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (617 aa)
MLH3MutL homolog 3. (1463 aa)
CCDC36Coiled-coil domain containing 36. (599 aa)
BAG6BCL2 associated athanogene 6. (1164 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1740 aa)
C1orf146Chromosome 1 open reading frame 146. (181 aa)
FSBPUncharacterized protein. (909 aa)
ENSCHIP00000003676RECA_2 domain-containing protein. (278 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
PSMD13PCI domain-containing protein. (376 aa)
FIGNL1Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa)
ENSCHIP00000002436Uncharacterized protein. (175 aa)
HSF2BPHeat shock transcription factor 2 binding protein. (338 aa)
SMC2Structural maintenance of chromosomes protein. (1191 aa)
LOC108634517Uncharacterized protein; Belongs to the actin family. (214 aa)
FANCAFA complementation group A. (1416 aa)
RPL10LRibosomal protein L10 like. (214 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (893 aa)
PGRMC1Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (194 aa)
SYCE1Synaptonemal complex central element protein 1. (320 aa)
LOC102176379Wee1-like protein kinase. (549 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (18%) [HD]