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P2RY6 P2RY6 NR4A3 NR4A3 HTR1B HTR1B TNF TNF CCDC142 CCDC142 ADAMTS1 ADAMTS1 CDKN1A CDKN1A MEF2D MEF2D NF1 NF1 IGFBP5 IGFBP5 NDRG2 NDRG2 PRKG1 PRKG1 CALCRL CALCRL DBH DBH CDKN1B CDKN1B MEF2C MEF2C MMP2 MMP2 MFN2 MFN2 MMP9 MMP9 FGF2 FGF2 IGF1 IGF1 CNN1 CNN1 FGF9 FGF9 FOXJ2 FOXJ2 MYOCD MYOCD PDCD4 PDCD4 GPER1 GPER1 DNMT1 DNMT1 PDGFB PDGFB ERN1 ERN1 ADIPOQ ADIPOQ BMPR1A BMPR1A RBM10 RBM10 TGFB3 TGFB3 LDLRAP1 LDLRAP1 GJA1 GJA1 JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (648 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
CCDC142Coiled-coil domain containing 142. (725 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
MEF2DMADS-box domain-containing protein. (513 aa)
NF1Neurofibromin 1. (2848 aa)
IGFBP5Insulin-like growth factor binding protein 5. (272 aa)
NDRG2NDRG family member 2. (371 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (465 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
DBHDopamine beta-hydroxylase. (616 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
MMP9Uncharacterized protein. (709 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FOXJ2Forkhead box J2. (561 aa)
MYOCDMyocardin. (982 aa)
PDCD4Programmed cell death 4. (513 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (955 aa)
ADIPOQC1q domain-containing protein. (283 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RBM10RNA binding motif protein 10. (921 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (310 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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