25 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	STOX1	Storkhead box 1. (981 aa)
	GATA3	GATA binding protein 3. (467 aa)
	SIX1	SIX homeobox 1. (284 aa)
	GDNF	Glial cell derived neurotrophic factor. (211 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	LHX1	LIM homeobox 1. (406 aa)
	MMRN2	Multimerin 2. (937 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	GREM1	Gremlin. (184 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (476 aa)
	SIX4	SIX homeobox 4. (784 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	SOX8	SRY-box transcription factor 8. (534 aa)
	HOXB7	Homeobox B7. (217 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	AR	Androgen receptor. (891 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	SIRT6	Sirtuin 6. (335 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CTNNB1	ENSCHIP00000024651	ENSCHIP00000031016	Tyrosine-protein kinase.	Catenin beta 1.	0.622
AR	CTNNB1	ENSCHIP00000024342	ENSCHIP00000031016	Androgen receptor.	Catenin beta 1.	0.943
AR	SOX9	ENSCHIP00000024342	ENSCHIP00000024523	Androgen receptor.	SRY-box transcription factor 9.	0.526
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	FGF2	ENSCHIP00000023678	ENSCHIP00000019134	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.872
BMP4	GATA3	ENSCHIP00000023678	ENSCHIP00000030187	Bone morphogenetic protein 4.	GATA binding protein 3.	0.544
BMP4	GDNF	ENSCHIP00000023678	ENSCHIP00000027133	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.603
BMP4	GJA1	ENSCHIP00000023678	ENSCHIP00000001879	Bone morphogenetic protein 4.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.525
BMP4	GREM1	ENSCHIP00000023678	ENSCHIP00000006985	Bone morphogenetic protein 4.	Gremlin.	0.946
BMP4	HOXB7	ENSCHIP00000023678	ENSCHIP00000017865	Bone morphogenetic protein 4.	Homeobox B7.	0.402
BMP4	LHX1	ENSCHIP00000023678	ENSCHIP00000025202	Bone morphogenetic protein 4.	LIM homeobox 1.	0.400
BMP4	LIF	ENSCHIP00000023678	ENSCHIP00000012397	Bone morphogenetic protein 4.	LIF interleukin 6 family cytokine.	0.725
BMP4	NOG	ENSCHIP00000023678	ENSCHIP00000005264	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.999
BMP4	SIX1	ENSCHIP00000023678	ENSCHIP00000029952	Bone morphogenetic protein 4.	SIX homeobox 1.	0.531
BMP4	SMO	ENSCHIP00000023678	ENSCHIP00000027079	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.639
BMP4	SOX9	ENSCHIP00000023678	ENSCHIP00000024523	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.769
BMP4	WNT2B	ENSCHIP00000023678	ENSCHIP00000004954	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.525
CTNNB1	ABL1	ENSCHIP00000031016	ENSCHIP00000024651	Catenin beta 1.	Tyrosine-protein kinase.	0.622
CTNNB1	AR	ENSCHIP00000031016	ENSCHIP00000024342	Catenin beta 1.	Androgen receptor.	0.943
CTNNB1	BMP4	ENSCHIP00000031016	ENSCHIP00000023678	Catenin beta 1.	Bone morphogenetic protein 4.	0.800