28 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (962 aa)
	WDR20	WD repeat domain 20. (581 aa)
	ENSCHIP00000001275	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (154 aa)
	ASTN2	Astrotactin 2. (1324 aa)
	GOPC	PDZ domain-containing protein. (463 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2589 aa)
	RIC3	RIC3 acetylcholine receptor chaperone. (361 aa)
	TOR1A	Torsin. (333 aa)
	LRIG2	Leucine rich repeats and immunoglobulin like domains 2. (1065 aa)
	TMEM35A	Transmembrane protein 35A. (177 aa)
	RAB11B	Uncharacterized protein. (224 aa)
	KCNAB2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (367 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2152 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	DMWD	DM1 locus, WD repeat containing. (668 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ERBB4	Protein kinase domain-containing protein. (462 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (289 aa)
	COMMD1	Copper metabolism domain containing 1. (188 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (701 aa)
	SNX33	Sorting nexin. (611 aa)
	TM9SF4	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
	TAX1BP3	Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (356 aa)
	ACTN2	Actinin alpha 2. (902 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA12	COMMD1	ENSCHIP00000020901	ENSCHIP00000018295	ATP binding cassette subfamily A member 12.	Copper metabolism domain containing 1.	0.438
ABCA7	PICALM	ENSCHIP00000027146	ENSCHIP00000014729	ATP binding cassette subfamily A member 7.	Phosphatidylinositol binding clathrin assembly protein.	0.828
AKT1	CTNNB1	ENSCHIP00000027335	ENSCHIP00000031016	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Catenin beta 1.	0.827
AKT1	ERBB4	ENSCHIP00000027335	ENSCHIP00000031292	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.459
AKT1	TNF	ENSCHIP00000027335	ENSCHIP00000004561	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.622
ARF6	ENSCHIP00000001275	ENSCHIP00000004584	ENSCHIP00000001275	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.901
COMMD1	ABCA12	ENSCHIP00000018295	ENSCHIP00000020901	Copper metabolism domain containing 1.	ATP binding cassette subfamily A member 12.	0.438
CTNNB1	AKT1	ENSCHIP00000031016	ENSCHIP00000027335	Catenin beta 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.827
CTNNB1	ERBB4	ENSCHIP00000031016	ENSCHIP00000031292	Catenin beta 1.	Protein kinase domain-containing protein.	0.624
CTNNB1	TAX1BP3	ENSCHIP00000031016	ENSCHIP00000009997	Catenin beta 1.	Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.	0.664
CTNNB1	TNF	ENSCHIP00000031016	ENSCHIP00000004561	Catenin beta 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.730
ENSCHIP00000001275	ARF6	ENSCHIP00000001275	ENSCHIP00000004584	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.901
ERBB4	AKT1	ENSCHIP00000031292	ENSCHIP00000027335	Protein kinase domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.459
ERBB4	CTNNB1	ENSCHIP00000031292	ENSCHIP00000031016	Protein kinase domain-containing protein.	Catenin beta 1.	0.624
ERBB4	NEDD4L	ENSCHIP00000031292	ENSCHIP00000003350	Protein kinase domain-containing protein.	NEDD4 like E3 ubiquitin protein ligase.	0.432
HFE	TNF	ENSCHIP00000006747	ENSCHIP00000004561	Homeostatic iron regulator; Belongs to the MHC class I family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.430
KCNAB2	RANGRF	ENSCHIP00000025986	ENSCHIP00000030186	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	RAN guanine nucleotide release factor.	0.408
NEDD4L	ERBB4	ENSCHIP00000003350	ENSCHIP00000031292	NEDD4 like E3 ubiquitin protein ligase.	Protein kinase domain-containing protein.	0.432
PICALM	ABCA7	ENSCHIP00000014729	ENSCHIP00000027146	Phosphatidylinositol binding clathrin assembly protein.	ATP binding cassette subfamily A member 7.	0.828
RANGRF	KCNAB2	ENSCHIP00000030186	ENSCHIP00000025986	RAN guanine nucleotide release factor.	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	0.408