STRINGSTRING
FZD9 FZD9 VAX1 VAX1 DRD2 DRD2 CTNNA1 CTNNA1 CDON CDON ENSCHIP00000003193 ENSCHIP00000003193 GLI1 GLI1 CX3CR1 CX3CR1 DCT DCT KDM1A KDM1A SMARCA1 SMARCA1 GPR37L1 GPR37L1 APPL2 APPL2 NF1 NF1 ITGB1 ITGB1 SKOR2 SKOR2 EMX1 EMX1 ASCL1 ASCL1 ENSCHIP00000011371 ENSCHIP00000011371 RHOA RHOA NF2 NF2 DMRTA2 DMRTA2 ELL3 ELL3 GLI3 GLI3 DLL4 DLL4 CIP2A CIP2A HIF1A HIF1A SLC16A2 SLC16A2 WNT5A WNT5A WNT3A WNT3A LIMS2 LIMS2 RAPGEF1 RAPGEF1 PTPRZ1 PTPRZ1 ILK ILK BTG2 BTG2 FGF2 FGF2 FOXO3 FOXO3 ID2 ID2 TRIM71 TRIM71 OTP OTP LRP2 LRP2 KIFAP3 KIFAP3 DISC1 DISC1 ADGRG1 ADGRG1 SOX10 SOX10 NR2E1 NR2E1 CEND1 CEND1 PROX1 PROX1 LRRK2 LRRK2 KDM2B KDM2B LHX1 LHX1 ZNF335 ZNF335 DISP3 DISP3 FOXG1 FOXG1 LHX5 LHX5 SHCBP1 SHCBP1 SMO SMO PAX6 PAX6 FZD3 FZD3 SHH SHH TOX TOX LHX2 LHX2 SMARCD3 SMARCD3 PTBP2 PTBP2 TP53 TP53 CTNNB1 CTNNB1 ENSCHIP00000033272 ENSCHIP00000033272 PTN PTN ZNF423 ZNF423
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CTNNA1Catenin alpha 1. (1018 aa)
CDONCell adhesion associated, oncogene regulated. (1254 aa)
ENSCHIP00000003193BHLH domain-containing protein. (122 aa)
GLI1GLI family zinc finger 1. (1105 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
DCTDopachrome tautomerase. (517 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (873 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1114 aa)
GPR37L1G protein-coupled receptor 37 like 1. (478 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
NF1Neurofibromin 1. (2848 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SKOR2SKI family transcriptional corepressor 2. (998 aa)
EMX1Empty spiracles homeobox 1. (288 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
RHOARas-like protein family member A. (193 aa)
NF2FERM domain-containing protein. (612 aa)
DMRTA2DMRT like family A2. (535 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
GLI3GLI family zinc finger 3. (1614 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
CIP2ACell proliferation regulating inhibitor of protein phosphatase 2A. (892 aa)
HIF1AUncharacterized protein. (823 aa)
SLC16A2Solute carrier family 16 member 2. (535 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (341 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1077 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2323 aa)
ILKIntegrin linked kinase. (452 aa)
BTG2BTG anti-proliferation factor 2. (164 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FOXO3Forkhead box O3. (672 aa)
ID2BHLH domain-containing protein. (134 aa)
TRIM71Tripartite motif containing 71. (876 aa)
OTPOrthopedia homeobox. (325 aa)
LRP2LDL receptor related protein 2. (4649 aa)
KIFAP3Kinesin associated protein 3. (749 aa)
DISC1DISC1 scaffold protein. (851 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (686 aa)
SOX10SRY-box transcription factor 10. (469 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (139 aa)
PROX1Prospero homeobox 1. (734 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
KDM2BLysine demethylase 2B. (1309 aa)
LHX1LIM homeobox 1. (406 aa)
ZNF335Zinc finger protein 335. (1345 aa)
DISP3Dispatched RND transporter family member 3. (1392 aa)
FOXG1Forkhead box G1. (538 aa)
LHX5LIM homeobox 5. (402 aa)
SHCBP1SHC binding and spindle associated 1. (672 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
PAX6Paired box 6. (486 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
TOXThymocyte selection associated high mobility group box. (527 aa)
LHX2Uncharacterized protein. (422 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
PTBP2Polypyrimidine tract binding protein 2. (537 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSCHIP00000033272FERM domain-containing protein. (580 aa)
PTNPleiotrophin. (183 aa)
ZNF423Zinc finger protein 423. (1308 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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