STRINGSTRING
GRHL2 GRHL2 GDF2 GDF2 PARN PARN CCT5 CCT5 FGF2 FGF2 JADE3 JADE3 PARP4 PARP4 MAPK3 MAPK3 GINS4 GINS4 NAT10 NAT10 PINX1 PINX1 ADIPOQ ADIPOQ ACVRL1 ACVRL1 PIF1 PIF1 DSCC1 DSCC1 ENSCHIP00000012571 ENSCHIP00000012571 CCT4 CCT4 ANKRD1 ANKRD1 STN1 STN1 EXOSC10 EXOSC10 BMPR2 BMPR2 ENSCHIP00000022338 ENSCHIP00000022338 LOC102170672 LOC102170672 RFC4 RFC4 LOC108635607 LOC108635607 LOC102175542 LOC102175542 CERS1 CERS1 MAPK1 MAPK1 TFDP1 TFDP1 NVL NVL MEAF6 MEAF6 ENSCHIP00000001595 ENSCHIP00000001595 PRKCQ PRKCQ PARP3 PARP3 CCT6A CCT6A JADE1 JADE1 PKIB PKIB NEK7 NEK7 POT1 POT1 DACH1 DACH1 HMBOX1 HMBOX1 HNRNPU HNRNPU ENSCHIP00000002380 ENSCHIP00000002380 CDKN1A CDKN1A SRC SRC NIBAN2 NIBAN2 TNKS TNKS CCDC174 CCDC174 WRAP53 WRAP53 PCNA PCNA SH2B1 SH2B1 PNKP PNKP LOC102174357 LOC102174357 TINF2 TINF2 FGFR4 FGFR4 AURKB AURKB CCT7 CCT7 HNRNPD HNRNPD ENSCHIP00000025330 ENSCHIP00000025330 XRCC5 XRCC5 FBXO4 FBXO4 NOX4 NOX4 GINS3 GINS3 PRKD2 PRKD2 CCT3 CCT3 DCP2 DCP2 GREM1 GREM1 PARM1 PARM1 ENSCHIP00000006258 ENSCHIP00000006258 HGF HGF TEN1 TEN1 MAP3K4 MAP3K4 NEK2 NEK2 RFC2 RFC2 MEN1 MEN1 MYC MYC CHTF18 CHTF18 MAPKAPK5 MAPKAPK5 PDGFB PDGFB RFC3 RFC3 TERF1 TERF1 LOC102189034 LOC102189034 CTNNB1 CTNNB1 ACD ACD HNRNPA1 HNRNPA1 DERPC DERPC TP53 TP53 SMOC2 SMOC2 CTC1 CTC1 TERF2 TERF2 GINS2 GINS2 LOC102185345 LOC102185345 TCP1 TCP1 CCT2 CCT2 KAT7 KAT7 ATM ATM DKC1 DKC1 POLG2 POLG2 ENSCHIP00000018363 ENSCHIP00000018363
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRHL2Grainyhead like transcription factor 2. (622 aa)
GDF2Growth differentiation factor 2. (430 aa)
PARNPoly(A)-specific ribonuclease. (638 aa)
CCT5Chaperonin containing TCP1 subunit 5. (541 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
JADE3Jade family PHD finger 3. (859 aa)
PARP4Poly [ADP-ribose] polymerase. (1739 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
ADIPOQC1q domain-containing protein. (283 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
DSCC1Uncharacterized protein. (388 aa)
ENSCHIP00000012571Uncharacterized protein. (386 aa)
CCT4T-complex protein 1 subunit delta. (541 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (370 aa)
EXOSC10Exosome component 10. (844 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ENSCHIP00000022338Uncharacterized protein. (300 aa)
LOC102170672T-complex protein 1 subunit delta. (529 aa)
RFC4Replication factor C subunit 4. (364 aa)
LOC108635607Uncharacterized protein. (512 aa)
LOC102175542Uncharacterized protein. (307 aa)
CERS1TLC domain-containing protein. (333 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
TFDP1Transcription factor. (410 aa)
NVLNuclear VCP like. (860 aa)
MEAF6MYST/Esa1 associated factor 6. (201 aa)
ENSCHIP00000001595Uncharacterized protein. (333 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (711 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
CCT6AUncharacterized protein. (531 aa)
JADE1Jade family PHD finger 1. (863 aa)
PKIBcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (79 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
POT1Protection of telomeres 1. (785 aa)
DACH1Dachshund family transcription factor 1. (761 aa)
HMBOX1Homeobox containing 1. (420 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
ENSCHIP00000002380Uncharacterized protein. (531 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
SRCTyrosine-protein kinase. (538 aa)
NIBAN2Niban apoptosis regulator 2. (744 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CCDC174Coiled-coil domain containing 174. (467 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SH2B1SH2B adaptor protein 1. (775 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
LOC102174357Uncharacterized protein. (510 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
FGFR4Fibroblast growth factor receptor. (870 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CCT7T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (355 aa)
ENSCHIP00000025330Uncharacterized protein. (484 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
FBXO4F-box protein 4. (393 aa)
NOX4NADPH oxidase 4. (578 aa)
GINS3GINS complex subunit 3. (216 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
CCT3T-complex protein 1 subunit gamma. (545 aa)
DCP2Decapping mRNA 2. (423 aa)
GREM1Gremlin. (184 aa)
PARM1Prostate androgen-regulated mucin-like protein 1. (300 aa)
ENSCHIP00000006258Uncharacterized protein. (474 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
TEN1Uncharacterized protein. (123 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1590 aa)
NEK2NIMA related kinase 2. (445 aa)
RFC2Replication factor C subunit 2. (352 aa)
MEN1Menin 1. (609 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CHTF18Chromosome transmission fidelity factor 18. (948 aa)
MAPKAPK5Protein kinase domain-containing protein. (431 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RFC3Replication factor C subunit 3. (356 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
LOC102189034Uncharacterized protein. (320 aa)
CTNNB1Catenin beta 1. (781 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
HNRNPA1Uncharacterized protein. (320 aa)
DERPCDERPC proline and glycine rich nuclear protein. (520 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SMOC2SPARC related modular calcium binding 2. (445 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
LOC102185345Uncharacterized protein. (483 aa)
TCP1T-complex 1. (556 aa)
CCT2Chaperonin containing TCP1 subunit 2. (535 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
DKC1Dyskerin pseudouridine synthase 1. (506 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
ENSCHIP00000018363Uncharacterized protein. (331 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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