96 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXO3	Forkhead box O3. (672 aa)
	MMP8	Matrix metallopeptidase 8. (470 aa)
	PAX2	Paired box 2. (467 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	ENSCHIP00000032547	APG6 domain-containing protein. (249 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (470 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	PARL	Rhomboid domain-containing protein. (377 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2. (616 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	PINK1	PTEN induced kinase 1. (587 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	FOXM1	Fork-head domain-containing protein. (763 aa)
	ENSCHIP00000030535	zf-RING_14 domain-containing protein. (149 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (217 aa)
	PAGE4	PAGE family member 4. (107 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	TUSC2	Uncharacterized protein. (110 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	SPHK2	Sphingosine kinase 2. (653 aa)
	COA8	Cytochrome c oxidase assembly factor 8. (193 aa)
	ZNF205	Zinc finger protein 205. (552 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	PON2	Paraoxonase 2. (367 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)
	SLC30A10	Solute carrier family 30 member 10. (486 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	BECN1	Uncharacterized protein. (448 aa)
	ENSCHIP00000023383	RBR-type E3 ubiquitin transferase. (84 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (456 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (737 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1130 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
	ENSCHIP00000021405	DHFR domain-containing protein. (156 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MT3	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
	CLCN3	Chloride channel protein. (866 aa)
	GCH1	GTP cyclohydrolase 1. (248 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1560 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2110 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	TFAP2A	Transcription factor AP-2 alpha. (485 aa)
	MPV17	Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (170 aa)
	ENSCHIP00000018611	Uncharacterized protein. (183 aa)
	THBS1	Thrombospondin 1. (1218 aa)
	XDH	FAD-binding PCMH-type domain-containing protein. (1331 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
	ARG2	Arginase. (354 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
	RIPK3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
	PARK2	Ubiquitin-like domain-containing protein. (293 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	ENSCHIP00000015111	Uncharacterized protein. (97 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	LOC102169668	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (188 aa)
	CRP	Pentaxin. (227 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
	ITGAM	Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
	RHOA	Ras-like protein family member A. (193 aa)
	DUOXA1	Dual oxidase maturation factor 1. (337 aa)
	SLC25A33	Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
	ENSCHIP00000011371	Uncharacterized protein. (193 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
	STK17A	Serine/threonine kinase 17a; Belongs to the protein kinase superfamily. (414 aa)
	HK2	Hexokinase 2. (917 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
	TSPO	Translocator protein. (169 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (140 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	GH1	Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	PON3	Paraoxonase 3. (354 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	BCO2	Beta-carotene oxygenase 2. (575 aa)
	PRCP	Prolylcarboxypeptidase. (511 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
	AATF	Apoptosis antagonizing transcription factor. (568 aa)
	ROMO1	Reactive oxygen species modulator 1. (79 aa)
	DUOXA2	Dual oxidase maturation factor 2. (320 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	RNF41	Ring finger protein 41. (317 aa)
	PRDX2	Thioredoxin domain-containing protein. (198 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (741 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	ENSCHIP00000021952	ENSCHIP00000002112	ATP binding cassette subfamily D member 1.	ATP binding cassette subfamily D member 2.	0.991
ABCD2	ABCD1	ENSCHIP00000002112	ENSCHIP00000021952	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 1.	0.991
ARG2	MMP3	ENSCHIP00000017404	ENSCHIP00000026267	Arginase.	Matrix metallopeptidase 3.	0.599
ARG2	PRCP	ENSCHIP00000017404	ENSCHIP00000007803	Arginase.	Prolylcarboxypeptidase.	0.438
ARG2	TLR4	ENSCHIP00000017404	ENSCHIP00000019512	Arginase.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.457
ARG2	TNF	ENSCHIP00000017404	ENSCHIP00000004561	Arginase.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.605
ATG5	BCL2	ENSCHIP00000021333	ENSCHIP00000015831	Autophagy protein 5; Involved in autophagic vesicle formation.	BH4_2 domain-containing protein.	0.863
ATG5	BECN1	ENSCHIP00000021333	ENSCHIP00000024304	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.986
ATG5	ENSCHIP00000032547	ENSCHIP00000021333	ENSCHIP00000032547	Autophagy protein 5; Involved in autophagic vesicle formation.	APG6 domain-containing protein.	0.681
ATG5	FOXO3	ENSCHIP00000021333	ENSCHIP00000019148	Autophagy protein 5; Involved in autophagic vesicle formation.	Forkhead box O3.	0.648
ATG5	HIF1A	ENSCHIP00000021333	ENSCHIP00000014770	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.473
ATG5	INS	ENSCHIP00000021333	ENSCHIP00000007610	Autophagy protein 5; Involved in autophagic vesicle formation.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.542
ATG5	PARK2	ENSCHIP00000021333	ENSCHIP00000015951	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like domain-containing protein.	0.676
ATG5	PINK1	ENSCHIP00000021333	ENSCHIP00000031148	Autophagy protein 5; Involved in autophagic vesicle formation.	PTEN induced kinase 1.	0.841
ATG5	RIPK1	ENSCHIP00000021333	ENSCHIP00000032711	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.527
ATG5	SNCA	ENSCHIP00000021333	ENSCHIP00000009503	Autophagy protein 5; Involved in autophagic vesicle formation.	Alpha-synuclein; Belongs to the synuclein family.	0.499
ATG5	SOD1	ENSCHIP00000021333	ENSCHIP00000012974	Autophagy protein 5; Involved in autophagic vesicle formation.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.	0.418
ATG5	TLR4	ENSCHIP00000021333	ENSCHIP00000019512	Autophagy protein 5; Involved in autophagic vesicle formation.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.412
ATG5	TNF	ENSCHIP00000021333	ENSCHIP00000004561	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.508
ATG5	TP53	ENSCHIP00000021333	ENSCHIP00000030141	Autophagy protein 5; Involved in autophagic vesicle formation.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.707