20 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (622 aa)
	FMR1	Fragile X mental retardation 1. (632 aa)
	AJUBA	Ajuba LIM protein. (571 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	PUM1	Pumilio RNA binding family member 1. (1186 aa)
	ZFP36	ZFP36 ring finger protein. (325 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TRUB1	TruB pseudouridine synthase family member 1. (351 aa)
	TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1. (386 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	WTIP	WT1 interacting protein. (428 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	FXR1	FMR1 autosomal homolog 1. (648 aa)
	LIMD1	LIM domains containing 1. (671 aa)
	TRIM71	Tripartite motif containing 71. (876 aa)
	DHX9	DExH-box helicase 9. (1271 aa)
	PUM2	Pumilio RNA binding family member 2. (1064 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJUBA	LIMD1	ENSCHIP00000031691	ENSCHIP00000017835	Ajuba LIM protein.	LIM domains containing 1.	0.940
AJUBA	WTIP	ENSCHIP00000031691	ENSCHIP00000031281	Ajuba LIM protein.	WT1 interacting protein.	0.945
BMP4	EGFR	ENSCHIP00000023678	ENSCHIP00000022759	Bone morphogenetic protein 4.	Receptor protein-tyrosine kinase.	0.440
BMP4	STAT3	ENSCHIP00000023678	ENSCHIP00000022282	Bone morphogenetic protein 4.	Signal transducer and activator of transcription.	0.563
BMP4	TP53	ENSCHIP00000023678	ENSCHIP00000030141	Bone morphogenetic protein 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.447
DDX5	DHX9	ENSCHIP00000008777	ENSCHIP00000019777	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DExH-box helicase 9.	0.993
DDX5	FMR1	ENSCHIP00000008777	ENSCHIP00000000274	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Fragile X mental retardation 1.	0.437
DDX5	FXR1	ENSCHIP00000008777	ENSCHIP00000017285	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	FMR1 autosomal homolog 1.	0.569
DDX5	TP53	ENSCHIP00000008777	ENSCHIP00000030141	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.788
DDX5	TRUB1	ENSCHIP00000008777	ENSCHIP00000023225	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	TruB pseudouridine synthase family member 1.	0.489
DHX9	DDX5	ENSCHIP00000019777	ENSCHIP00000008777	DExH-box helicase 9.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.993
DHX9	EGFR	ENSCHIP00000019777	ENSCHIP00000022759	DExH-box helicase 9.	Receptor protein-tyrosine kinase.	0.576
DHX9	PUM1	ENSCHIP00000019777	ENSCHIP00000010460	DExH-box helicase 9.	Pumilio RNA binding family member 1.	0.404
DHX9	ZFP36	ENSCHIP00000019777	ENSCHIP00000027167	DExH-box helicase 9.	ZFP36 ring finger protein.	0.449
EGFR	BMP4	ENSCHIP00000022759	ENSCHIP00000023678	Receptor protein-tyrosine kinase.	Bone morphogenetic protein 4.	0.440
EGFR	DHX9	ENSCHIP00000022759	ENSCHIP00000019777	Receptor protein-tyrosine kinase.	DExH-box helicase 9.	0.576
EGFR	STAT3	ENSCHIP00000022759	ENSCHIP00000022282	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.984
EGFR	TP53	ENSCHIP00000022759	ENSCHIP00000030141	Receptor protein-tyrosine kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.893
FMR1	DDX5	ENSCHIP00000000274	ENSCHIP00000008777	Fragile X mental retardation 1.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.437
FMR1	FXR1	ENSCHIP00000000274	ENSCHIP00000017285	Fragile X mental retardation 1.	FMR1 autosomal homolog 1.	0.974