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| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | HELB | DNA helicase B. (1077 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (593 aa) |
| | TTI2 | TELO2 interacting protein 2. (508 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (903 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | MARCHF7 | Membrane associated ring-CH-type finger 7. (713 aa) |
| | DHX9 | DExH-box helicase 9. (1271 aa) |
| | ANKRD1 | Ankyrin repeat domain 1. (319 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2556 aa) |
| | MBTD1 | Mbt domain containing 1. (628 aa) |
| | ENSCHIP00000031621 | Uncharacterized protein. (159 aa) |
| | SIRT6 | Sirtuin 6. (335 aa) |
| | ENSCHIP00000031547 | HTH_48 domain-containing protein. (342 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1020 aa) |
| | ENSCHIP00000031435 | Uncharacterized protein. (77 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa) |
| | KMT5B | Lysine methyltransferase 5B. (883 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | PML | Promyelocytic leukemia. (868 aa) |
| | MORF4L1 | Mortality factor 4 like 1. (363 aa) |
| | SKIL | c-SKI_SMAD_bind domain-containing protein. (684 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (149 aa) |
| | NACC2 | NACC family member 2. (585 aa) |
| | CCAR2 | Cell cycle and apoptosis regulator 2. (939 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa) |
| | ENSCHIP00000003493 | MPN domain-containing protein. (262 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (920 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (412 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | EPC1 | Enhancer of polycomb homolog. (842 aa) |
| | FIGNL1 | Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa) |
| | NUDT16L1 | Nudix hydrolase 16 like 1. (211 aa) |
| | DDX39B | DExD-box helicase 39B. (428 aa) |
| | FUS | FUS RNA binding protein. (522 aa) |
| | FXR2 | FMR1 autosomal homolog 2. (673 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (325 aa) |
| | PBK | Protein kinase domain-containing protein. (325 aa) |
| | ENSCHIP00000001690 | Uncharacterized protein. (204 aa) |
| | ENSCHIP00000001650 | TCTP domain-containing protein; Belongs to the TCTP family. (154 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (201 aa) |
| | ACKR3 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | ENSCHIP00000001380 | Reverse transcriptase domain-containing protein. (704 aa) |
| | ENSCHIP00000001374 | Uncharacterized protein. (222 aa) |
| | BCLAF1 | BCL2 associated transcription factor 1. (943 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (764 aa) |
| | SHLD2 | Shieldin complex subunit 2. (918 aa) |
| | FMR1 | Fragile X mental retardation 1. (632 aa) |
| | ENSCHIP00000000105 | c-SKI_SMAD_bind domain-containing protein. (664 aa) |
| | ENSCHIP00000000047 | RING-type domain-containing protein. (101 aa) |
| | EEF1E1 | GST C-terminal domain-containing protein. (174 aa) |
| | INO80E | INO80 complex subunit E. (241 aa) |
| | NEK4 | NIMA related kinase 4. (788 aa) |
| | ENSCHIP00000017311 | Protein kinase domain-containing protein. (274 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (873 aa) |
| | WDR48 | WD repeat domain 48. (678 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | HSF1 | HSF_DOMAIN domain-containing protein. (537 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (270 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | TRIM32 | Tripartite motif containing 32. (695 aa) |
| | KMT5C | Lysine methyltransferase 5C. (455 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1391 aa) |
| | LOC102168398 | TCTP domain-containing protein; Belongs to the TCTP family. (172 aa) |
| | PPP4R3B | Protein phosphatase 4 regulatory subunit 3B. (820 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) |
| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | NKX3-1 | NK3 homeobox 1. (239 aa) |
| | INO80D | INO80 complex subunit D. (1026 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1471 aa) |
| | FMN2 | FH2 domain-containing protein. (1457 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa) |
| | ARID2 | AT-rich interaction domain 2. (1835 aa) |
| | CXCL12 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (195 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (732 aa) |
| | SPRED1 | Sprouty related EVH1 domain containing 1. (433 aa) |
| | ZNHIT1 | Zinc finger HIT-type containing 1. (205 aa) |
| | LOC102188481 | Uncharacterized protein. (379 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (781 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (452 aa) |
| | TPT1 | TCTP domain-containing protein; Belongs to the TCTP family. (172 aa) |
| | EP400 | E1A binding protein p400. (3022 aa) |
| | COPS3 | COP9 signalosome subunit 3. (423 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (279 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (622 aa) |
| | LOC102189098 | MPN domain-containing protein. (291 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (626 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | ENSCHIP00000009605 | Uncharacterized protein. (61 aa) |
| | FXR1 | FMR1 autosomal homolog 1. (648 aa) |
| | MRNIP | MRN complex interacting protein. (361 aa) |
| | CLUL1 | Clusterin; Belongs to the clusterin family. (464 aa) |
| | TRIM28 | Tripartite motif containing 28. (837 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | FAM178B | Family with sequence similarity 178 member B. (699 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (889 aa) |
| | ENSCHIP00000010820 | Uncharacterized protein. (107 aa) |
| | ACTB | Uncharacterized protein. (375 aa) |
| | KMT5A | Lysine methyltransferase 5A. (422 aa) |
| | SOX4 | SRY-box transcription factor 4. (504 aa) |
| | TRIP12 | Thyroid hormone receptor interactor 12. (2067 aa) |
| | YY1 | YY1 transcription factor. (415 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3658 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (217 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (148 aa) |
| | POLQ | DNA polymerase theta. (2587 aa) |
| | HMGA2 | Uncharacterized protein. (104 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (326 aa) |
| | IER3 | Immediate early response 3. (156 aa) |
| | CD74 | CD74 molecule. (261 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (791 aa) |
| | TPT1-2 | TCTP domain-containing protein; Belongs to the TCTP family. (192 aa) |
| | OTUB1 | Ubiquitin thioesterase. (271 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (264 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | CCDC197 | Coiled-coil domain containing 197. (288 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (210 aa) |
| | HDAC10 | Histone deacetylase 10. (672 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (458 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1894 aa) |
| | SIRT7 | Sirtuin 7. (405 aa) |
| | LOC108636227 | Uncharacterized protein. (463 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (410 aa) |
| | ZNF385A | Zinc finger protein 385A. (393 aa) |
| | FBH1 | F-box DNA helicase 1. (1048 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (855 aa) |
| | ENSCHIP00000015471 | MRG domain-containing protein. (231 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (525 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (782 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | ENSCHIP00000015226 | KH type-2 domain-containing protein. (204 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (800 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | HIC1 | HIC ZBTB transcriptional repressor 1. (733 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (540 aa) |
| | KLHL15 | Kelch like family member 15. (604 aa) |
| | CD44 | CD44 molecule (Indian blood group). (715 aa) |
| | ENSCHIP00000024183 | Uncharacterized protein. (207 aa) |
| | BRD8 | Bromodomain containing 8. (1216 aa) |
| | TERF2IP | Uncharacterized protein. (400 aa) |
| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2801 aa) |
| | PTTG1IP | PTTG1 interacting protein. (150 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (325 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1167 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1298 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1208 aa) |
| | AXIN2 | Axin 2. (844 aa) |
| | DDIAS | DNA damage induced apoptosis suppressor. (999 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2486 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1413 aa) |
| | PAXIP1 | PAX interacting protein 1. (1006 aa) |
| | HELQ | Helicase, POLQ like. (1115 aa) |
| | ENSCHIP00000022242 | Uncharacterized protein. (395 aa) |
| | MORF4L2 | Mortality factor 4 like 2. (287 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (729 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (144 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | HDGFL2 | HDGF like 2. (658 aa) |
| | MCRS1 | Microspherule protein 1. (462 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (487 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (222 aa) |
| | ENSCHIP00000020312 | TCTP domain-containing protein; Belongs to the TCTP family. (123 aa) |
| | SMYD2 | SET and MYND domain containing 2. (433 aa) |
| | ENSCHIP00000020042 | MPN domain-containing protein. (245 aa) |
| | RMI2 | Uncharacterized protein. (161 aa) |
| | FBXO4 | F-box protein 4. (393 aa) |
| | DYRK1A | Dual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (235 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | THOC5 | THO complex 5. (694 aa) |
| | FBXO5 | F-box protein 5. (448 aa) |
| | DEK | DEK proto-oncogene. (378 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (511 aa) |
| | BRCC3 | MPN domain-containing protein. (288 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (916 aa) |
| | MAGEF1 | MAGE family member F1. (299 aa) |
| | TMEM161A | Transmembrane protein 161A. (495 aa) |
| | PARG | Poly(ADP-ribose) glycohydrolase. (972 aa) |
| | FANCB | Uncharacterized protein. (447 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | THOC1 | THO complex 1. (657 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (513 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (395 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1056 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa) |
| | UBQLN4 | Ubiquilin 4. (601 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (413 aa) |
| | SHLD1 | Shieldin complex subunit 1. (206 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (357 aa) |
| | POT1 | Protection of telomeres 1. (785 aa) |
| | BCL2L12 | BCL2 like 12. (252 aa) |
| | HNRNPK | Uncharacterized protein. (454 aa) |
| | VPS72 | Vacuolar protein sorting 72 homolog. (364 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (640 aa) |
| | MRGBP | Uncharacterized protein. (204 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) |
| | BID | Uncharacterized protein. (244 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | FOXM1 | Fork-head domain-containing protein. (763 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa) |
| | TFPT | TCF3 fusion partner. (254 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | ARMT1 | Acidic residue methyltransferase 1. (441 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | ZNF365 | Zinc finger protein 365. (406 aa) |
| | OOEP | Oocyte expressed protein. (140 aa) |
| | WAS | WASP actin nucleation promoting factor. (536 aa) |
| | ZCWPW1 | Zinc finger CW-type and PWWP domain containing 1. (645 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (738 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (522 aa) |
| | NPAS2 | Neuronal PAS domain protein 2. (817 aa) |
| | FEM1B | Fem-1 homolog B. (627 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | PARPBP | PARP1 binding protein. (580 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (795 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (345 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | MUC1 | SEA domain-containing protein. (578 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (468 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (764 aa) |
