STRINGSTRING
ENSCHIP00000000047 ENSCHIP00000000047 DHX9 DHX9 ENSCHIP00000020042 ENSCHIP00000020042 ANKLE1 ANKLE1 MCRS1 MCRS1 HDGFL2 HDGFL2 RUVBL1 RUVBL1 SPIRE2 SPIRE2 NSMCE1 NSMCE1 MORF4L2 MORF4L2 HELQ HELQ PAXIP1 PAXIP1 POGZ POGZ RIF1 RIF1 EGFR EGFR XRCC1 XRCC1 ENDOG ENDOG NFRKB NFRKB SLF2 SLF2 KHDC3L KHDC3L BRD8 BRD8 ENSCHIP00000024183 ENSCHIP00000024183 EYA4 EYA4 ATR ATR EYA1 EYA1 DMAP1 DMAP1 UIMC1 UIMC1 RNF168 RNF168 NPAS2 NPAS2 PNKP PNKP DTX3L DTX3L PRKCG PRKCG ZCWPW1 ZCWPW1 WAS WAS OOEP OOEP EPC2 EPC2 RUVBL2 RUVBL2 TFPT TFPT BABAM1 BABAM1 FOXM1 FOXM1 EEF1E1 EEF1E1 MFSD11 MFSD11 KMT5B KMT5B ENSCHIP00000031435 ENSCHIP00000031435 ENSCHIP00000031547 ENSCHIP00000031547 SIRT6 SIRT6 MBTD1 MBTD1 FAM168A FAM168A EYA3 EYA3 BRCA1 BRCA1 TTI2 TTI2 INO80 INO80 NKX3-1 NKX3-1 INO80D INO80D PLA2R1 PLA2R1 FMN2 FMN2 TIMELESS TIMELESS EYA2 EYA2 ARID2 ARID2 MAD2L2 MAD2L2 SIRT1 SIRT1 SPRED1 SPRED1 ZNHIT1 ZNHIT1 SPIRE1 SPIRE1 EP400 EP400 CCDC117 CCDC117 DDX5 DDX5 LOC102189098 LOC102189098 RPS3 RPS3 ENSCHIP00000009605 ENSCHIP00000009605 TRIM28 TRIM28 FGF10 FGF10 FAM178B FAM178B RBBP8 RBBP8 ACTB ACTB YY1 YY1 BCL7C BCL7C MYC MYC UBE2V2 UBE2V2 PRKDC PRKDC RAD51AP1 RAD51AP1 YEATS4 YEATS4 RAD9A RAD9A MRGBP MRGBP VPS72 VPS72 SHLD1 SHLD1 NSMCE4A NSMCE4A PRKCD PRKCD SLF1 SLF1 ACTR8 ACTR8 MMS19 MMS19 PIAS4 PIAS4 KAT5 KAT5 FANCB FANCB TMEM161A TMEM161A MGMT MGMT WRAP53 WRAP53 HIC1 HIC1 PCNA PCNA MAP3K20 MAP3K20 ENSCHIP00000015226 ENSCHIP00000015226 PMAIP1 PMAIP1 PARP3 PARP3 ENSCHIP00000015471 ENSCHIP00000015471 PARP9 PARP9 FBH1 FBH1 ZNF385A ZNF385A ABRAXAS1 ABRAXAS1 ATM ATM ERCC8 ERCC8 ACTL6A ACTL6A HDAC10 HDAC10 BCL7A BCL7A MRNIP MRNIP FXR1 FXR1 ENSCHIP00000017311 ENSCHIP00000017311 INO80E INO80E PARP1 PARP1 SPIDR SPIDR BRCC3 BRCC3 ANKRD1 ANKRD1 ERCC6 ERCC6 KMT5C KMT5C ING3 ING3 TIGAR TIGAR WDR48 WDR48 MORF4L1 MORF4L1 SKIL SKIL CEBPG CEBPG NACC2 NACC2 CCAR2 CCAR2 RNF8 RNF8 ENSCHIP00000003493 ENSCHIP00000003493 EPC1 EPC1 FUS FUS FXR2 FXR2 UCHL5 UCHL5 PBK PBK ENSCHIP00000001690 ENSCHIP00000001690 BABAM2 BABAM2 MEAF6 MEAF6 ENSCHIP00000001380 ENSCHIP00000001380 BCLAF1 BCLAF1 SMCHD1 SMCHD1 SHLD2 SHLD2 FMR1 FMR1 ENSCHIP00000000105 ENSCHIP00000000105
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
DHX9DExH-box helicase 9. (1271 aa)
ENSCHIP00000020042MPN domain-containing protein. (245 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (487 aa)
MCRS1Microspherule protein 1. (462 aa)
HDGFL2HDGF like 2. (658 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
SPIRE2Spire type actin nucleation factor 2. (729 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (266 aa)
MORF4L2Mortality factor 4 like 2. (287 aa)
HELQHelicase, POLQ like. (1115 aa)
PAXIP1PAX interacting protein 1. (1006 aa)
POGZPogo transposable element derived with ZNF domain. (1413 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
ENDOGEndonuclease. (299 aa)
NFRKBNuclear factor related to kappaB binding protein. (1298 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1167 aa)
KHDC3LMOEP19 domain-containing protein. (325 aa)
BRD8Bromodomain containing 8. (1216 aa)
ENSCHIP00000024183Uncharacterized protein. (207 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (468 aa)
UIMC1Ubiquitin interaction motif containing 1. (795 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
NPAS2Neuronal PAS domain protein 2. (817 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (738 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (645 aa)
WASWASP actin nucleation promoting factor. (536 aa)
OOEPOocyte expressed protein. (140 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa)
TFPTTCF3 fusion partner. (254 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
FOXM1Fork-head domain-containing protein. (763 aa)
EEF1E1GST C-terminal domain-containing protein. (174 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
KMT5BLysine methyltransferase 5B. (883 aa)
ENSCHIP00000031435Uncharacterized protein. (77 aa)
ENSCHIP00000031547HTH_48 domain-containing protein. (342 aa)
SIRT6Sirtuin 6. (335 aa)
MBTD1Mbt domain containing 1. (628 aa)
FAM168AFamily with sequence similarity 168 member A. (235 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
TTI2TELO2 interacting protein 2. (508 aa)
INO80INO80 complex ATPase subunit. (1566 aa)
NKX3-1NK3 homeobox 1. (239 aa)
INO80DINO80 complex subunit D. (1026 aa)
PLA2R1Phospholipase A2 receptor 1. (1471 aa)
FMN2FH2 domain-containing protein. (1457 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (195 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
SPRED1Sprouty related EVH1 domain containing 1. (433 aa)
ZNHIT1Zinc finger HIT-type containing 1. (205 aa)
SPIRE1Spire type actin nucleation factor 1. (781 aa)
EP400E1A binding protein p400. (3022 aa)
CCDC117Coiled-coil domain containing 117. (279 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (622 aa)
LOC102189098MPN domain-containing protein. (291 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ENSCHIP00000009605Uncharacterized protein. (61 aa)
TRIM28Tripartite motif containing 28. (837 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FAM178BFamily with sequence similarity 178 member B. (699 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
ACTBUncharacterized protein. (375 aa)
YY1YY1 transcription factor. (415 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (217 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (148 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
RAD51AP1RAD51 associated protein 1. (326 aa)
YEATS4YEATS domain containing 4. (227 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
MRGBPUncharacterized protein. (204 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
SHLD1Shieldin complex subunit 1. (206 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (413 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1056 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
PIAS4Protein inhibitor of activated STAT 4. (513 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
FANCBUncharacterized protein. (447 aa)
TMEM161ATransmembrane protein 161A. (495 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (222 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
HIC1HIC ZBTB transcriptional repressor 1. (733 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
ENSCHIP00000015226KH type-2 domain-containing protein. (204 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
ENSCHIP00000015471MRG domain-containing protein. (231 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
FBH1F-box DNA helicase 1. (1048 aa)
ZNF385AZinc finger protein 385A. (393 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (410 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa)
ACTL6AActin like 6A; Belongs to the actin family. (458 aa)
HDAC10Histone deacetylase 10. (672 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (210 aa)
MRNIPMRN complex interacting protein. (361 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
ENSCHIP00000017311Protein kinase domain-containing protein. (274 aa)
INO80EINO80 complex subunit E. (241 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
SPIDRScaffold protein involved in DNA repair. (916 aa)
BRCC3MPN domain-containing protein. (288 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
KMT5CLysine methyltransferase 5C. (455 aa)
ING3Inhibitor of growth protein. (418 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
WDR48WD repeat domain 48. (678 aa)
MORF4L1Mortality factor 4 like 1. (363 aa)
SKILc-SKI_SMAD_bind domain-containing protein. (684 aa)
CEBPGCCAAT enhancer binding protein gamma. (149 aa)
NACC2NACC family member 2. (585 aa)
CCAR2Cell cycle and apoptosis regulator 2. (939 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
ENSCHIP00000003493MPN domain-containing protein. (262 aa)
EPC1Enhancer of polycomb homolog. (842 aa)
FUSFUS RNA binding protein. (522 aa)
FXR2FMR1 autosomal homolog 2. (673 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (325 aa)
PBKProtein kinase domain-containing protein. (325 aa)
ENSCHIP00000001690Uncharacterized protein. (204 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
MEAF6MYST/Esa1 associated factor 6. (201 aa)
ENSCHIP00000001380Reverse transcriptase domain-containing protein. (704 aa)
BCLAF1BCL2 associated transcription factor 1. (943 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
SHLD2Shieldin complex subunit 2. (918 aa)
FMR1Fragile X mental retardation 1. (632 aa)
ENSCHIP00000000105c-SKI_SMAD_bind domain-containing protein. (664 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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