STRINGSTRING
ENSCHIP00000000670 ENSCHIP00000000670 POLB POLB ENSCHIP00000002654 ENSCHIP00000002654 APEX1 APEX1 POLE POLE VWA5B2 VWA5B2 RFC2 RFC2 FEN1 FEN1 POLD2 POLD2 POLD1 POLD1 PARP1 PARP1 RFC5 RFC5 ATAD5 ATAD5 PARP3 PARP3 PCNA PCNA POLD3 POLD3 LIG1 LIG1 RPA1 RPA1 PARP2 PARP2 POLE2 POLE2 POLE4 POLE4 VWA5B1 VWA5B1 ADPRHL2 ADPRHL2 POLD4 POLD4 ENSCHIP00000009163 ENSCHIP00000009163 RCBTB2 RCBTB2 RFC3 RFC3 RCBTB1 RCBTB1 MEIOB MEIOB ENSCHIP00000012960 ENSCHIP00000012960 PARG PARG VWA5A VWA5A APEX2 APEX2 RFC1 RFC1 POLE3 POLE3 RFC4 RFC4 RPA3 RPA3 RPA2 RPA2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000000670DNA_pol_B_thumb domain-containing protein. (54 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1254 aa)
RFC2Replication factor C subunit 2. (352 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
POLD1DNA polymerase. (1115 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
RFC5Replication factor C subunit 5. (339 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLD3Uncharacterized protein. (464 aa)
LIG1DNA ligase. (915 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PARP2Poly [ADP-ribose] polymerase. (533 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1183 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (368 aa)
POLD4Uncharacterized protein. (132 aa)
ENSCHIP00000009163Uncharacterized protein. (122 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
ENSCHIP00000012960DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (287 aa)
PARGPoly(ADP-ribose) glycohydrolase. (972 aa)
VWA5AVon Willebrand factor A domain containing 5A. (783 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
RFC1Replication factor C subunit 1. (1143 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (147 aa)
RFC4Replication factor C subunit 4. (364 aa)
RPA3Uncharacterized protein. (121 aa)
RPA2Replication protein A2. (270 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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