STRINGSTRING
WRN WRN PCNA PCNA POLD1 POLD1 RPA2 RPA2 DNA2 DNA2 TERF2IP TERF2IP RPA3 RPA3 TINF2 TINF2 POLD3 POLD3 TERF2 TERF2 ACD ACD RPA1 RPA1 ENSCHIP00000002654 ENSCHIP00000002654 FEN1 FEN1 POLD2 POLD2 LOC102188481 LOC102188481 POLD4 POLD4 TERF1 TERF1 POT1 POT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WRNWRN RecQ like helicase. (1405 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLD1DNA polymerase. (1115 aa)
RPA2Replication protein A2. (270 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
TERF2IPUncharacterized protein. (400 aa)
RPA3Uncharacterized protein. (121 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
POLD3Uncharacterized protein. (464 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
LOC102188481Uncharacterized protein. (379 aa)
POLD4Uncharacterized protein. (132 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
POT1Protection of telomeres 1. (785 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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