STRINGSTRING
DNA2 DNA2 RPA2 RPA2 POLD1 POLD1 CCNA2 CCNA2 ANKRD44 ANKRD44 DKC1 DKC1 RFC5 RFC5 POLA1 POLA1 PCNA PCNA PRIM1 PRIM1 LIG1 LIG1 RPA1 RPA1 PRIM2 PRIM2 ACD ACD CTC1 CTC1 TERF2 TERF2 RUVBL2 RUVBL2 POLD3 POLD3 TINF2 TINF2 RPA3 RPA3 ANKRD66 ANKRD66 ANKRD28 ANKRD28 ENSCHIP00000012571 ENSCHIP00000012571 RTEL1 RTEL1 CCNA1 CCNA1 MEIOB MEIOB RCBTB1 RCBTB1 RFC3 RFC3 RCBTB2 RCBTB2 SHQ1 SHQ1 NOP10 NOP10 TERF1 TERF1 GAR1 GAR1 POLD4 POLD4 LOC102188481 LOC102188481 RECQL4 RECQL4 ENSCHIP00000007586 ENSCHIP00000007586 BLM BLM POLD2 POLD2 TEN1 TEN1 FEN1 FEN1 RFC2 RFC2 CHTF18 CHTF18 TERT TERT ENSCHIP00000003593 ENSCHIP00000003593 CDK2 CDK2 ENSCHIP00000002654 ENSCHIP00000002654 ENSCHIP00000001595 ENSCHIP00000001595 PPP6C PPP6C WRAP53 WRAP53 PPP6R2 PPP6R2 NHP2 NHP2 WRN WRN POT1 POT1 PIF1 PIF1 DSCC1 DSCC1 EXD2 EXD2 POLA2 POLA2 TERF2IP TERF2IP TRUB1 TRUB1 RFC4 RFC4 PPP6R3 PPP6R3 RFC1 RFC1 CDK3 CDK3 STN1 STN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DNA2DNA replication helicase/nuclease 2. (1062 aa)
RPA2Replication protein A2. (270 aa)
POLD1DNA polymerase. (1115 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
ANKRD44Ankyrin repeat domain 44. (993 aa)
DKC1Dyskerin pseudouridine synthase 1. (506 aa)
RFC5Replication factor C subunit 5. (339 aa)
POLA1DNA polymerase. (1468 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
LIG1DNA ligase. (915 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PRIM2Uncharacterized protein. (219 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa)
POLD3Uncharacterized protein. (464 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
RPA3Uncharacterized protein. (121 aa)
ANKRD66Ankyrin repeat domain 66. (210 aa)
ANKRD28Ankyrin repeat domain 28. (1083 aa)
ENSCHIP00000012571Uncharacterized protein. (386 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (638 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (214 aa)
POLD4Uncharacterized protein. (132 aa)
LOC102188481Uncharacterized protein. (379 aa)
RECQL4RecQ like helicase 4. (1176 aa)
ENSCHIP00000007586H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (198 aa)
BLMBLM RecQ like helicase. (1429 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
TEN1Uncharacterized protein. (123 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
CHTF18Chromosome transmission fidelity factor 18. (948 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
ENSCHIP00000003593Uncharacterized protein. (64 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
ENSCHIP00000001595Uncharacterized protein. (333 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (917 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
WRNWRN RecQ like helicase. (1405 aa)
POT1Protection of telomeres 1. (785 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
DSCC1Uncharacterized protein. (388 aa)
EXD2Exonuclease 3'-5' domain containing 2. (642 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
TERF2IPUncharacterized protein. (400 aa)
TRUB1TruB pseudouridine synthase family member 1. (351 aa)
RFC4Replication factor C subunit 4. (364 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
RFC1Replication factor C subunit 1. (1143 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (370 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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