STRINGSTRING
PIK3R2 PIK3R2 KDR KDR ABI2 ABI2 PAK1 PAK1 XK XK HRAS HRAS CTNNA1 CTNNA1 LOC102187402 LOC102187402 TENM4 TENM4 MAPKAPK2 MAPKAPK2 ELMO3 ELMO3 ACTG1 ACTG1 KRAS KRAS BCAR1 BCAR1 JUP JUP PTK2B PTK2B ENSCHIP00000031987 ENSCHIP00000031987 TENM1 TENM1 CTNNB1 CTNNB1 TENM2 TENM2 CASS4 CASS4 SHB SHB EFS EFS NCF2 NCF2 PLCG1 PLCG1 VEGFB VEGFB LOC102190345 LOC102190345 ACTL8 ACTL8 CTNND1 CTNND1 STX12 STX12 PRKCA PRKCA PRKACB PRKACB VEGFC VEGFC RAC1 RAC1 FNDC3B FNDC3B LOC102178713 LOC102178713 VEGFD VEGFD WASF2 WASF2 MAPK13 MAPK13 NRAS NRAS RICTOR RICTOR PAK3 PAK3 HSP90AA1 HSP90AA1 NCF1 NCF1 PGF PGF VAV2 VAV2 ENSCHIP00000024778 ENSCHIP00000024778 SPHK1 SPHK1 CALM1 CALM1 RAC3 RAC3 PIK3R1 PIK3R1 NEDD9 NEDD9 SHC2 SHC2 ELMO1 ELMO1 AXL AXL SH2D2A SH2D2A PIK3CB PIK3CB LPXN LPXN DOCK1 DOCK1 FLT1 FLT1 CAV1 CAV1 BRK1 BRK1 MAPK11 MAPK11 PAK2 PAK2 ITGB3 ITGB3 WASF3 WASF3 CYFIP1 CYFIP1 BAIAP2 BAIAP2 CSDE1 CSDE1 ENSCHIP00000017131 ENSCHIP00000017131 PRKCB PRKCB SHD SHD HSH2D HSH2D PRKACA PRKACA PRR5 PRR5 MAPK12 MAPK12 ROCK1 ROCK1 PIK3CA PIK3CA NRP2 NRP2 VAV3 VAV3 FNDC3A FNDC3A LOC102180084 LOC102180084 HSPB1 HSPB1 CDH5 CDH5 THEM4 THEM4 PDPK1 PDPK1 ARVCF ARVCF PDGFA PDGFA ABI1 ABI1 PRKCD PRKCD STX7 STX7 CYBA CYBA RASA1 RASA1 PTK2 PTK2 CDC42 CDC42 MAPKAPK3 MAPKAPK3 RHOA RHOA FLT4 FLT4 ENSCHIP00000011371 ENSCHIP00000011371 ACTB ACTB NOS3 NOS3 ROCK2 ROCK2 SZRD1 SZRD1 TGFB1I1 TGFB1I1 SHE SHE SHF SHF NCF4 NCF4 CYBB CYBB NCK1 NCK1 RNF222 RNF222 ELMO2 ELMO2 WASF1 WASF1 VAV1 VAV1 CALM2 CALM2 TENM3 TENM3 PRKCZ PRKCZ PXN PXN NCK2 NCK2 NCKAP1 NCKAP1 NCKAP1L NCKAP1L ITGAV ITGAV VEGFA VEGFA CRK CRK FYN FYN LOC102176514 LOC102176514 CYFIP2 CYFIP2 NRP1 NRP1 ENSCHIP00000003472 ENSCHIP00000003472 SRC SRC ACTBL2 ACTBL2 MAPK14 MAPK14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R2Uncharacterized protein. (724 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
ABI2Abl interactor 2. (475 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
XKXK-related protein. (444 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CTNNA1Catenin alpha 1. (1018 aa)
LOC102187402Teneurin N-terminal domain-containing protein. (172 aa)
TENM4Teneurin transmembrane protein 4. (2855 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (410 aa)
ELMO3Engulfment and cell motility 3. (720 aa)
ACTG1Actin gamma 1. (376 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (848 aa)
JUPJunction plakoglobin. (745 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSCHIP00000031987Non-specific serine/threonine protein kinase. (199 aa)
TENM1Teneurin transmembrane protein 1. (1982 aa)
CTNNB1Catenin beta 1. (781 aa)
TENM2Teneurin transmembrane protein 2. (2665 aa)
CASS4Cas scaffold protein family member 4. (811 aa)
SHBSH2 domain-containing protein. (507 aa)
EFSEmbryonal Fyn-associated substrate. (572 aa)
NCF2Neutrophil cytosolic factor 2. (506 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
LOC102190345WH2 domain-containing protein. (462 aa)
ACTL8Actin like 8; Belongs to the actin family. (389 aa)
CTNND1Catenin delta 1. (939 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
PRKCAUncharacterized protein. (605 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
RAC1Rac family small GTPase 1. (187 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
LOC102178713Uncharacterized protein. (1054 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
WASF2WH2 domain-containing protein. (506 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1707 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (140 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
ENSCHIP00000024778Uncharacterized protein; Belongs to the calmodulin family. (134 aa)
SPHK1Sphingosine kinase 1. (392 aa)
CALM1Calmodulin 2; Belongs to the calmodulin family. (149 aa)
RAC3Rac family small GTPase 3. (192 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
SHC2Uncharacterized protein. (565 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
SH2D2ASH2 domain containing 2A. (420 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (390 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1888 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BRK1Uncharacterized protein. (75 aa)
MAPK11Mitogen-activated protein kinase. (417 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (786 aa)
WASF3WASP family member 3. (501 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1268 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSCHIP00000017131Teneurin N-terminal domain-containing protein. (209 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
HSH2DSH2 domain-containing protein. (86 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
PRR5Proline rich 5. (391 aa)
MAPK12Mitogen-activated protein kinase 12. (359 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
LOC102180084Uncharacterized protein; Belongs to the actin family. (319 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
THEM4Thioesterase superfamily member 4. (268 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
ARVCFARVCF delta catenin family member. (955 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (250 aa)
ABI1Abl interactor 1. (508 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
CDC42Uncharacterized protein. (191 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
RHOARas-like protein family member A. (193 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
ACTBUncharacterized protein. (375 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
SZRD1SUZ domain-containing protein. (138 aa)
TGFB1I1Transforming growth factor beta 1 induced transcript 1. (415 aa)
SHESrc homology 2 domain containing E. (511 aa)
SHFSrc homology 2 domain containing F. (239 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NCK1Cytoplasmic protein. (377 aa)
RNF222Ring finger protein 222. (208 aa)
ELMO2Engulfment and cell motility 2. (725 aa)
WASF1WASP family member 1. (570 aa)
VAV1Vav guanine nucleotide exchange factor 1. (844 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (150 aa)
TENM3Teneurin transmembrane protein 3. (2587 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (581 aa)
NCK2Cytoplasmic protein. (376 aa)
NCKAP1NCK associated protein 1. (1134 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC102176514Uncharacterized protein. (182 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ENSCHIP00000003472Uncharacterized protein. (75 aa)
SRCTyrosine-protein kinase. (538 aa)
ACTBL2Actin beta like 2. (376 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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