STRINGSTRING
ARPC3 ARPC3 YES1 YES1 ENSCHIP00000000967 ENSCHIP00000000967 ENSCHIP00000001384 ENSCHIP00000001384 PAK1 PAK1 HRAS HRAS LOC108634517 LOC108634517 EFNA1 EFNA1 EPHB3 EPHB3 SRC SRC ACTBL2 ACTBL2 ARPC2 ARPC2 ENSCHIP00000003772 ENSCHIP00000003772 EFNB1 EFNB1 EFNA4 EFNA4 NGEF NGEF ELSPBP1 ELSPBP1 LOC102176514 LOC102176514 FYN FYN ENSCHIP00000005672 ENSCHIP00000005672 NCK2 NCK2 EPHA5 EPHA5 FMN2 FMN2 LOC102168811 LOC102168811 EFNA5 EFNA5 ROCK2 ROCK2 ENSCHIP00000010891 ENSCHIP00000010891 ACTB ACTB ENSCHIP00000011371 ENSCHIP00000011371 ARPC1A ARPC1A RHOA RHOA ARHGEF28 ARHGEF28 CDC42 CDC42 PTK2 PTK2 ENSCHIP00000012316 ENSCHIP00000012316 RASA1 RASA1 ACTR2 ACTR2 ARPC5L ARPC5L EPHB6 EPHB6 APH1A APH1A EPHA3 EPHA3 SDC2 SDC2 EPHA2 EPHA2 ARPC4 ARPC4 CFL2 CFL2 ACTR3 ACTR3 LOC102180084 LOC102180084 FNDC3A FNDC3A ENSCHIP00000015370 ENSCHIP00000015370 VAV3 VAV3 ENSCHIP00000015572 ENSCHIP00000015572 ROCK1 ROCK1 GRIN1 GRIN1 WASL WASL MMP2 MMP2 MYL12A MYL12A MMP9 MMP9 ARPC5 ARPC5 SDCBP SDCBP TIAM1 TIAM1 LIMK2 LIMK2 DSTN DSTN PSENEN PSENEN PAK2 PAK2 EPHB1 EPHB1 APH1B APH1B EFNB2 EFNB2 EPHA7 EPHA7 ARPC1B ARPC1B ENSCHIP00000023781 ENSCHIP00000023781 RAC3 RAC3 EPHA1 EPHA1 FMN1 FMN1 EPHB4 EPHB4 GIT1 GIT1 VAV2 VAV2 ENSCHIP00000025632 ENSCHIP00000025632 LYN LYN EPHA6 EPHA6 GRIN2B GRIN2B ITSN1 ITSN1 PAK3 PAK3 EPHB2 EPHB2 EFNA3 EFNA3 EPHA8 EPHA8 EPHA10 EPHA10 LOC102178713 LOC102178713 FNDC3B FNDC3B RAC1 RAC1 CFL1 CFL1 ACTL8 ACTL8 EPHA4 EPHA4 PSEN2 PSEN2 PSEN1 PSEN1 EFNA2 EFNA2 ARHGEF7 ARHGEF7 ENSCHIP00000032612 ENSCHIP00000032612 ACTG1 ACTG1 SDCBP2 SDCBP2 ACTR3B ACTR3B ENSCHIP00000033297 ENSCHIP00000033297 NCSTN NCSTN EFNB3 EFNB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (194 aa)
YES1Tyrosine-protein kinase. (541 aa)
ENSCHIP00000000967SH3 domain-containing protein. (527 aa)
ENSCHIP00000001384Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (237 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC108634517Uncharacterized protein; Belongs to the actin family. (214 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
EPHB3EPH receptor B3. (999 aa)
SRCTyrosine-protein kinase. (538 aa)
ACTBL2Actin beta like 2. (376 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
ENSCHIP00000003772Eph LBD domain-containing protein. (266 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
NGEFNeuronal guanine nucleotide exchange factor. (706 aa)
ELSPBP1Epididymal sperm binding protein 1. (225 aa)
LOC102176514Uncharacterized protein. (182 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSCHIP00000005672Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa)
NCK2Cytoplasmic protein. (376 aa)
EPHA5EPH receptor A5. (1031 aa)
FMN2FH2 domain-containing protein. (1457 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (205 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
ENSCHIP00000010891Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (116 aa)
ACTBUncharacterized protein. (375 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
RHOARas-like protein family member A. (193 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1766 aa)
CDC42Uncharacterized protein. (191 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
ENSCHIP00000012316Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (358 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (159 aa)
EPHB6EPH receptor B6. (1011 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
EPHA3EPH receptor A3. (984 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
EPHA2EPH receptor A2. (975 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (178 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (405 aa)
LOC102180084Uncharacterized protein; Belongs to the actin family. (319 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSCHIP00000015370WD_REPEATS_REGION domain-containing protein. (342 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
ENSCHIP00000015572Fibronectin type-II domain-containing protein. (154 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
MYL12AMyosin light chain 12A. (178 aa)
MMP9Uncharacterized protein. (709 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
SDCBPSyndecan binding protein. (359 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
LIMK2LIM domain kinase 2. (638 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (165 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (115 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
EPHB1EPH receptor B1. (984 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
EPHA7EPH receptor A7. (998 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
ENSCHIP00000023781ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (159 aa)
RAC3Rac family small GTPase 3. (192 aa)
EPHA1EPH receptor A1. (968 aa)
FMN1Formin 1. (1435 aa)
EPHB4EPH receptor B4. (993 aa)
GIT1GIT ArfGAP 1. (738 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
ENSCHIP00000025632WD_REPEATS_REGION domain-containing protein. (353 aa)
LYNTyrosine-protein kinase. (512 aa)
EPHA6Uncharacterized protein. (808 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
ITSN1Intersectin 1. (1716 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
EPHB2EPH receptor B2. (1016 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (232 aa)
EPHA8EPH receptor A8. (1005 aa)
EPHA10EPH receptor A10. (1008 aa)
LOC102178713Uncharacterized protein. (1054 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
RAC1Rac family small GTPase 1. (187 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (165 aa)
ACTL8Actin like 8; Belongs to the actin family. (389 aa)
EPHA4EPH receptor A4. (986 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (213 aa)
ARHGEF7Uncharacterized protein. (845 aa)
ENSCHIP00000032612FH2 domain-containing protein. (185 aa)
ACTG1Actin gamma 1. (376 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (418 aa)
ENSCHIP00000033297Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (165 aa)
NCSTNNicastrin. (709 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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