17 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (887 aa)
	POLD1	DNA polymerase. (1115 aa)
	RPA2	Replication protein A2. (270 aa)
	MLH1	MutL homolog 1. (758 aa)
	POLD4	Uncharacterized protein. (132 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	ENSCHIP00000002654	Uncharacterized protein. (121 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
	RPA3	Uncharacterized protein. (121 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (932 aa)
	EXO1	Exonuclease 1. (835 aa)
	POLD3	Uncharacterized protein. (464 aa)
	LIG1	DNA ligase. (915 aa)
	MEIOB	Meiosis specific with OB-fold. (467 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCHIP00000002654	EXO1	ENSCHIP00000002654	ENSCHIP00000010493	Uncharacterized protein.	Exonuclease 1.	0.519
ENSCHIP00000002654	LIG1	ENSCHIP00000002654	ENSCHIP00000032333	Uncharacterized protein.	DNA ligase.	0.623
ENSCHIP00000002654	MEIOB	ENSCHIP00000002654	ENSCHIP00000011102	Uncharacterized protein.	Meiosis specific with OB-fold.	0.842
ENSCHIP00000002654	MLH1	ENSCHIP00000002654	ENSCHIP00000008937	Uncharacterized protein.	MutL homolog 1.	0.496
ENSCHIP00000002654	MSH2	ENSCHIP00000002654	ENSCHIP00000025009	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.476
ENSCHIP00000002654	MSH6	ENSCHIP00000002654	ENSCHIP00000012330	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.470
ENSCHIP00000002654	PCNA	ENSCHIP00000002654	ENSCHIP00000015091	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.622
ENSCHIP00000002654	PMS1	ENSCHIP00000002654	ENSCHIP00000011013	Uncharacterized protein.	PMS1 homolog 1, mismatch repair system component.	0.435
ENSCHIP00000002654	PMS2	ENSCHIP00000002654	ENSCHIP00000017031	Uncharacterized protein.	PMS1 homolog 2, mismatch repair system component.	0.455
ENSCHIP00000002654	POLD1	ENSCHIP00000002654	ENSCHIP00000019836	Uncharacterized protein.	DNA polymerase.	0.626
ENSCHIP00000002654	POLD2	ENSCHIP00000002654	ENSCHIP00000005641	Uncharacterized protein.	DNA polymerase delta 2, accessory subunit.	0.488
ENSCHIP00000002654	POLD3	ENSCHIP00000002654	ENSCHIP00000027965	Uncharacterized protein.	Uncharacterized protein.	0.560
ENSCHIP00000002654	RPA1	ENSCHIP00000002654	ENSCHIP00000032279	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.975
ENSCHIP00000002654	RPA2	ENSCHIP00000002654	ENSCHIP00000020251	Uncharacterized protein.	Replication protein A2.	0.865
EXO1	ENSCHIP00000002654	ENSCHIP00000010493	ENSCHIP00000002654	Exonuclease 1.	Uncharacterized protein.	0.519
EXO1	LIG1	ENSCHIP00000010493	ENSCHIP00000032333	Exonuclease 1.	DNA ligase.	0.837
EXO1	MEIOB	ENSCHIP00000010493	ENSCHIP00000011102	Exonuclease 1.	Meiosis specific with OB-fold.	0.766
EXO1	MLH1	ENSCHIP00000010493	ENSCHIP00000008937	Exonuclease 1.	MutL homolog 1.	0.976
EXO1	MSH2	ENSCHIP00000010493	ENSCHIP00000025009	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.991
EXO1	MSH6	ENSCHIP00000010493	ENSCHIP00000012330	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.986