STRINGSTRING
POLD3 POLD3 POLE4 POLE4 POLE2 POLE2 RPA1 RPA1 POLD1 POLD1 ENSCHIP00000012960 ENSCHIP00000012960 PCNA PCNA ATAD5 ATAD5 RFC5 RFC5 MEIOB MEIOB ENSCHIP00000000670 ENSCHIP00000000670 POLB POLB RCBTB1 RCBTB1 RFC3 RFC3 RCBTB2 RCBTB2 ENSCHIP00000009163 ENSCHIP00000009163 POLD4 POLD4 POLD2 POLD2 FEN1 FEN1 RFC2 RFC2 LIG1 LIG1 POLE POLE APEX1 APEX1 ENSCHIP00000002654 ENSCHIP00000002654 RPA2 RPA2 APEX2 APEX2 RFC1 RFC1 POLE3 POLE3 RFC4 RFC4 RPA3 RPA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD3Uncharacterized protein. (464 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
POLD1DNA polymerase. (1115 aa)
ENSCHIP00000012960DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (287 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
RFC5Replication factor C subunit 5. (339 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
ENSCHIP00000000670DNA_pol_B_thumb domain-containing protein. (54 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
ENSCHIP00000009163Uncharacterized protein. (122 aa)
POLD4Uncharacterized protein. (132 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
LIG1DNA ligase. (915 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
RPA2Replication protein A2. (270 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
RFC1Replication factor C subunit 1. (1143 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (147 aa)
RFC4Replication factor C subunit 4. (364 aa)
RPA3Uncharacterized protein. (121 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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